ACR Meeting Abstracts

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Abstracts tagged "treatment"

  • Abstract Number: L06 • 2018 ACR/ARHP Annual Meeting

    Safety and Efficacy of Filgotinib in a Phase 3 Trial of Patients with Active Rheumatoid Arthritis and Inadequate Response or Intolerance to Biologic Dmards

    Mark C. Genovese1, Kenneth C. Kalunian2, David Walker3, Jacques-Eric Gottenberg4, Kurt de Vlam5, Neelufar Mozaffarian6, Beatrix Bartok6, Franziska Matzkies6, Jie Gao6, Ying Guo6, Chantal Tasset7, John S. Sundy6 and Tsutomu Takeuchi8, 1Division of Immunology & Rheumatology, Stanford University, Stanford, CA, 2Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, 3Northumbria Healthcare, United Kingdom, United Kingdom, 4Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Department of Rheumatology, Universitair Ziekenhuis Leuven, Leuven, Belgium, 6Gilead Sciences, Inc., Foster City, CA, 7Galapagos NV, Mechelen, Belgium, Mechelen, Belgium, 8Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Filgotinib (FIL), an oral, selective, Janus Kinase 1 (JAK1) inhibitor was effective in phase 2 studies of active RA in patients (pts) with insufficient…
  • Abstract Number: 575 • 2018 ACR/ARHP Annual Meeting

    Time to Discontinuation of Biologic Therapy By Mechanism of Action in Rheumatoid Arthritis: Results from a Rheumatoid Arthritis Cohort

    Mohammad Movahedi1, Elliot Hepworth2, Reza Mirza2, Angela Cesta3, Maggie Larche4 and Claire Bombardier1,5,6, 1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Internal Medicine, McMaster University, Hamilton, ON, Canada, 3Ontario Best Practices Research Initiative, University Health Network, Toronto, ON, Canada, 4Medicine, McMaster University, Hamilton, ON, Canada, 5University of Toronto, Department of Medicine (DOM) and Institute of Health Policy Management, and Evaluation (IHPME), Toronto, ON, Canada, 6Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Patients with rheumatoid arthritis (RA) may discontinue their biologic disease modifying antirheumatic drug (bDMARDs) due to non-response, loss of response or adverse events. However,…
  • Abstract Number: 2822 • 2018 ACR/ARHP Annual Meeting

    Should We Prefer Leflunomide to Methotrexate in Combination with Biologics? a Systematic Review and a Meta-Analysis

    Guillaume Decarriere1, Thomas Barnetche2, Cédric Lukas3, Cécile Gaujoux-Viala4, Bernard Combe5, Jacques Morel6 and Claire I. Daien7, 1Department of Rheumatology, CHU Lapeyronie, Montpellier, France, 2Rheumatology Department, FHU ACRONIM, Bordeaux University Hospital, Bordeaux, France, 3Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, 4Rheumatology, Nîmes University Hospital and EA2415 Montpellier University, Nîmes, France, 5Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, 6Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, 7Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: In rheumatoid arthritis (RA), biologics are more efficient in combination with methotrexate (MTX) than in monotherapy. When MTX cannot be used, others csDMARD can…
  • Abstract Number: 597 • 2018 ACR/ARHP Annual Meeting

    Characteristics of Patients and Predictors of Composite Disease Activity Scores for Switching to Monotherapy Vs Continuing TNF Inhibitor and Methotrexate Combination Therapy in RA: A Retrospective Analysis of the Brigham and Women’s Rheumatoid Arthritis Sequential Study Registry

    Nancy A. Shadick1, Michael E Weinblatt1, Christine K Iannaccone2, Michelle Frits3, Tigwa Davis4, Christopher Young4, David H. Collier5, Mahdi Gharaibeh5 and Bradley S. Stolshek6, 1Brigham and Women's Hospital, Boston, MA, 2Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 4Health Analytics, LLC, Columbia, MD, 5Amgen Inc., Thousand Oaks, CA, 6Amgen, Inc., Thousand Oaks, CA

    Background/Purpose: Biologics in combination with methotrexate (MTX) are being incorporated earlier in rheumatoid arthritis (RA) therapy to prevent long-term damage and maintain patient function. While…
  • Abstract Number: 2878 • 2018 ACR/ARHP Annual Meeting

    Phase II Clinical Trials Systematically Overestimate Treatment Effects of Subsequent Phase III Trials in Rheumatoid Arthritis

    Andreas Kerschbaumer1, Harald Herkner2, Josef S. Smolen3 and Daniel Aletaha4, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department for Emergency Medicine, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria, 4Medical University of Vienna, Vienna, Austria

    Background/Purpose: Phase 3 (P3) clinical trials are the mainstay of drug development in all areas of medicine, including rheumatology, allowing to determine safety and efficacy…
  • Abstract Number: 629 • 2018 ACR/ARHP Annual Meeting

    Real-World Use of Tofacitinib Compared with Tumor Necrosis Factor Inhibitors in a Cohort of 211 Patients with Rheumatoid Arthritis: Data from a Drug-Based Registry Study in Taiwan

    Song-Chou Hsieh1, Yi-Hsing Chen2, Wei-Sheng Chen3, Wen-Chan Tsai4, Jui-Chieh Hu5, Hsiang-Cheng Chen6, Jack Mardekian7 and Chacun Lai8, 1National Taiwan University Hospital, Taipei, Taiwan, 2Taichung Veterans General Hospital, Taichung City, Taiwan, 3Taipei Veterans General Hospital, Taipei, Taiwan, 4Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, 5Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 6National Defense Medical Center & Tri-Services General Hospital, Taipei, Taiwan, 7Pfizer Global Biometrics & Data Management, NY, NY, 8Pfizer PFE Limited, New Taipei, Taiwan

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Tofacitinib was approved in December 2014 for RA under Taiwan’s National Health…
  • Abstract Number: 2966 • 2018 ACR/ARHP Annual Meeting

    Ultrasound Shows Rapid Reduction of Uric Load during Treat-to-Target Approach in Gout Patients: Results from a Longitudinal Study

    Hilde B Hammer1, Lars Fritjof Karoliussen2, Lene Terslev3, Espen A. Haavardsholm1, Tore Kvien4 and Till Uhlig5, 1Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark, 4RAID working group for EULAR, Zurich, Switzerland, 5Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose:  Uric monosodium urate (MSU) depositions are detected by ultrasound (US), and US is included in the ACR/EULAR classification criteria for gout. OMERACT definitions for…
  • Abstract Number: 827 • 2018 ACR/ARHP Annual Meeting

    Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes and Adverse Events

    Caitrin Coffey1, Michael Richter1, Cynthia S. Crowson2, Matthew J. Koster3, Kenneth J. Warrington4 and Ashima Makol3, 1Internal Medicine, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Rheumatology, Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: Rheumatoid vasculitis (RV) is a rare systemic inflammatory process affecting small to medium sized blood vessels in patients with rheumatoid arthritis (RA). RV confers…
  • Abstract Number: 887 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety of the Novel Oral Janus Kinase (JAK) Inhibitor, Peficitinib (ASP015K), in a Phase 3, Double-Blind, Placebo-Controlled, Randomized Study of Patients with RA Who Had an Inadequate Response to Dmards

    Yoshiya Tanaka1, Tsutomu Takeuchi2, Sakae Tanaka3, Atsushi Kawakami4, Manabu Iwasaki5, Yeong Wook Song6, Yi-Hsing Chen7, Mitsuhiro Rokuda8, Hiroyuki Izutsu8, Satoshi Ushijima8, Yuichiro Kaneko8, Teruaki Shiomi8 and Emi Yamada8, 1University of Occupational and Environmental Health, Kitakyushu, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Nagasaki University, Nagasaki, Japan, 4University of Tokyo, Tokyo, Japan, 5Yokohama City University, Yokohama, Japan, 6Seoul National University Hospital, Seoul, Korea, Republic of (South), 7Taichung Veterans General Hospital, Taichung City, Taiwan, 8Astellas Pharma, Inc., Tokyo, Japan

    Background/Purpose: Peficitinib (ASP015K), a novel oral JAK inhibitor, demonstrated efficacy as once-daily monotherapy in patients with moderate to severe RA in a phase 2b study…
  • Abstract Number: 888 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety of the Novel Oral Janus Kinase (JAK) Inhibitor, Peficitinib (ASP015K), in a Phase 3, Double-Blind, Placebo-Controlled, Randomized Study of Patients with RA Who Had an Inadequate Response to Methotrexate

    Tsutomu Takeuchi1, Yoshiya Tanaka2, Sakae Tanaka3, Atsushi Kawakami4, Manabu Iwasaki5, Mitsuhiro Rokuda6, Hiroyuki Izutsu6, Satoshi Ushijima6, Yuichiro Kaneko6, Teruaki Shiomi6 and Emi Yamada6, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Nagasaki University, Nagasaki, Japan, 4University of Tokyo, Tokyo, Japan, 5Yokohama City University, Yokohama, Japan, 6Astellas Pharma, Inc., Tokyo, Japan

    Background/Purpose: Peficitinib (ASP015K), a novel oral JAK inhibitor, demonstrated efficacy as once-daily monotherapy in patients with moderate-to-severe RA in a phase 2b study (NCT01649999)1. We…
  • Abstract Number: 963 • 2018 ACR/ARHP Annual Meeting

    Long-Term Safety of Tofacitinib up to 9.5 Years: A Comprehensive Integrated Analysis of the RA Clinical Development Program

    Stanley Cohen1, Yoshiya Tanaka2, Xavier Mariette3, Jeffrey R. Curtis4, Eun Bong Lee5, Peter Nash6, Kevin Winthrop7, Christina Charles-Schoeman8, Lisy Wang9, Connie Chen10, Kenneth Kwok10, Pinaki Biswas10, Andrea Shapiro11, Ann Madsen10 and Jürgen Wollenhaupt12, 1Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Paris-Sud University, Le Kremlin Bicêtre, France, 4University of Alabama at Birmingham, Birmingham, AL, 5Seoul National University, Seoul, Korea, Republic of (South), 6University of Queensland, Brisbane, Australia, 7Oregon Health and Science University, Portland, OR, 8University of California, Los Angeles, CA, 9Pfizer Inc, Groton, CT, 10Pfizer Inc, New York, NY, 11Pfizer Inc, Peapack, NJ, 12Schön-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Here, we report the largest integrated safety analysis of tofacitinib to date…
  • Abstract Number: 1519 • 2018 ACR/ARHP Annual Meeting

    Patient Characteristics Associated with Discontinuation of Tofacitinib for the Treatment of Rheumatoid Arthritis in Open-Label, Long-Term Extension Studies up to 9.5 Years

    Jeffrey R. Curtis1, Jürgen Wollenhaupt2, Katerina Chatzidionysiou3, Sander W. Tas4, Lisy Wang5, Harry Shi6, María Montoro7, Petra Neregård8, Palle Dahl9 and Vassilis Tsekouras10, 1University of Alabama at Birmingham, Birmingham, AL, 2Schön Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 3Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 4Amsterdam Rheumatology and Immunology Center, Academic Medical Center, Amsterdam, Netherlands, 5Pfizer Inc, Groton, CT, 6Pfizer Inc, Collegeville, PA, 7Pfizer Inc, Madrid, Spain, 8Pfizer Inc, Stochholm, Sweden, 9Pfizer Inc, Ballerup, Denmark, 10Pfizer Inc, Athens, Greece

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. We explored characteristics of patients (pts) who discontinued (d/c) open-label, long-term extension…
  • Abstract Number: 1526 • 2018 ACR/ARHP Annual Meeting

    Baseline Characteristics and Outcomes in Patients with Anemia in Clinical Studies of Tofacitinib

    Burkhard Moeller1, Axel Finckh2, Jose Maria Alvaro-Gracia3, Godehard Scholz1, Daniel Aletaha4, Francesca Biondo5, Sander Strengholt6, Jose L Rivas7, Carol A Connell8 and Harry Shi9, 1Inselspital-University Hospital, Bern, Switzerland, 2University Hospital of Geneva, Geneva, Switzerland, 3Hospital Universitario de La Princesa, Madrid, Spain, 4Medical University of Vienna, Vienna, Austria, 5Pfizer Inc, Rome, Italy, 6Pfizer Inc, Capelle aan den IJssel, Netherlands, 7Pfizer SLU, Madrid, Spain, 8Pfizer Inc, Groton, CT, 9Pfizer Inc, Collegeville, PA

    Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. The purpose of this study is to describe the profile of patients…
  • Abstract Number: 1538 • 2018 ACR/ARHP Annual Meeting

    Moderate Adverse Drug Reactions Due to Disease Modifying Drugs in a Cohort of Patients with Incident Rheumatoid Arthritis

    Lydia A Alcazar1, Dalifer Freites Núñez1, Isabel Hernández-Rodríguez2, Judit Font Urgelles2, Pia Mercedes Lois2, Benjamín Fernández-Gutiérrez2, Juan A Jover Jover1 and Zulema Rosales Rosado1,2, 1Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 2Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose: In rheumatology, we are aware of the possibility to develop adverse drug reactions (ADR) to the widely used Disease Modifying Drugs (DMARD). We are…
  • Abstract Number: 1539 • 2018 ACR/ARHP Annual Meeting

    Safety of Methotrexate and Leflunomide Combination Therapy in the Treatment of Rheumatoid Arthritis

    María Badilla1, Nicia Moldenhauer2, Diego Neira3, Luis Muñoz4 and Oscar Neira1, 1Rheumatology Section., Hospital del Salvador, Universidad de Chile., Santiago, Chile, 2Rheumatology Section, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 3Internal Medicine Departament, Hospital del Salvador, Universidad de Chile, Santiago, Chile, 4Pharmacy Department, Hospital del Salvador, Santiago, Chile

    Background/Purpose: Best treatment of Rheumatoid Arthritis (RA) requires to begin early, with a tight control, including nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, disease-modifying antirheumatic drugs (DMARDs)…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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