Abstracts tagged "treatment"

Abstract Number: 1274 • 2012 ACR/ARHP Annual Meeting
Relationship Between Morning Stiffness Duration and Severity, Pain Intensity, and Measures of Disease Activity in a 12 Week Efficacy Study of a Modified (Delayed-Release) Prednisone Plus Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis
Frank Buttgereit¹, John R. Kirwan², Kenneth G. Saag³, Reike Alten⁴, Amy Grahn⁵, Patricia Rice⁶ and Maarten Boers⁷, ¹Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom, ³Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁴Charité Univ Medicine, Berlin, Germany, ⁵Clinical Development, Horizon Pharma, Inc, Deerfield, IL, ⁶Statistics, CliniRx Research, Naperville, IL, ⁷Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: RA patients typically present with pain and morning stiffness (MS). MS is predictive of both functional disability and escalated RA care, but the best…
Abstract Number: 452 • 2012 ACR/ARHP Annual Meeting
Effectiveness and Tolerance Infiltration Intraarticular Corticosteroid According to Dose
Daniele F. Pereira¹, Rita N.V. Furtado², Natalia P. Machado³ and Jamil Natour⁴, ¹Disciplina de Reumatologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil, ²Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil, ³Disciplina de Reumatologia, Universidade Federal de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: The optimal dose of corticosteroid to be used in intraarticular injection is not well established. The objective of this study is to compare the…
Abstract Number: L12 • 2012 ACR/ARHP Annual Meeting
Short- and Long-Term Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Patients with Rheumatoid Arthritis and an Inadequate Response to TNF Inhibitors: Analyses of Pooled Phase 2, Phase 3, and Long-Term Extension Studies
G. Burmester¹, Ricardo Blanco², Andrea Rubbert-Roth³, Thijs Hendrikx⁴, Kenneth Kwok⁵, John Bradley⁶, Samuel H. Zwillich⁶, Birgitta Benda⁷ and Charles A. Mebus⁶, ¹Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Charité University Medicine Berlin, Berlin, Germany, ²Rheumatology, Hospital Universitario Marques De Valdecilla, Santander, Spain, ³Internal Medicine I, University of Cologne, Cologne, Germany, ⁴Pfizer bv, Capelle aan den IJssel, Netherlands, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc., Collegeville, PA
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor investigated as a targeted immunomodulator and disease-modifying therapy for rheumatoid arthritis (RA). The efficacy and safety…
Abstract Number: 2510 • 2012 ACR/ARHP Annual Meeting
Patient and Provider Factors Associated with Compliance with Rheumatoid Arthritis Treatment Recommendations
Leslie R. Harrold¹, George W. Reed², Katherine C. Saunders³, Ying Shan¹, Tanya Spruill⁴ and Jeffrey D. Greenberg⁵, ¹Dept of Medicine, UMass Medical School, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Corrona, LLC., Southborough, MA, ⁴Center for Healthful Behavior Change, Department of Population Health, NYU School of Medicine, New York, NY, ⁵New York Hospital for Joint Disease, New York, NY
Background/Purpose: Only approximately 50% of rheumatoid arthritis (RA) patient with active disease receive care consistent with the American College of Rheumatology (ACR) recommendations for the…
Abstract Number: 1561 • 2012 ACR/ARHP Annual Meeting
Factors Influencing Implementation of Intensive Treatment Strategies for Early Rheumatoid Arthritis
Sabrina Meyfroidt¹, Diederik De Cock¹, Kristien Van der Elst², Laura van Hulst³, Marlies Hulscher³, Johan Joly⁴, Rene Westhovens⁵ and Patrick Verschueren⁵, ¹Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, ²Department of Development and Regeneration, Neuro-musculo-skeletal Research Unit, University Hospitals KULeuven, Leuven, Belgium, ³Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴University Hospitals Leuven on behalf of the CareRA Study Group, Leuven, Belgium, ⁵Rheumatology, University Hospitals KULeuven, Leuven, Belgium
Background/Purpose: Despite the availability and demonstrated effectiveness of intensive treatment strategies for early rheumatoid arthritis (RA), a discrepancy seems to exist between theoretical acceptance and…
Abstract Number: 1275 • 2012 ACR/ARHP Annual Meeting
Fast Remission Response to Etanercept At Week 4 Predicts Better Long-Term Outcomes in Early and Established Rheumatoid Arthritis Compared to Slower Response At Week 12
Bernd Raffeiner¹, Costantino Botsios², Francesca Ometto², Mariagrazia Canova², Livio Bernardi², Cristiana Vezzari², Silvano Todesco², Paolo Sfriso² and Leonardo Punzi², ¹Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit - University of Padova, Padova, Italy
Background/Purpose: Achievement of clinical remission not only early in disease course but also early in treatment course may be critical for functional outcome of patients…
Abstract Number: 465 • 2012 ACR/ARHP Annual Meeting
The Comparative Effectiveness of Oral Methotrexate Versus Subcutaneous Methotrexate for the Treatment of Early Rheumatoid Arthritis
Glen S. Hazlewood¹, J. Carter Thorne², Janet E. Pope³, Gilles Boire⁴, Boulos Haraoui⁵, Carol A. Hitchon⁶, Edward Keystone⁷, Diane Tin⁸, CATCH Investigators⁹ and Vivian P. Bykerk¹⁰, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²Southlake Regional Health Centre, Newmarket, ON, Canada, ³Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ⁴Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷University of Toronto, Toronto, ON, Canada, ⁸The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Toronto, ON, Canada, ¹⁰Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: To determine the comparative effectiveness of subcutaneous (sc) versus oral methotrexate (MTX) as initial therapy for patients with early rheumatoid arthritis (ERA) in routine…
Abstract Number: 2486 • 2012 ACR/ARHP Annual Meeting
Radiographic, Clinical and Functional Comparison of Tofacitinib Monotherapy Versus Methotrexate in Methotrexate-Naïve Patients with Rheumatoid Arthritis
Eun Bong Lee¹, Roy Fleischmann², Stephen Hall³, Ronald F. van Vollenhoven⁴, John Bradley⁵, David Gruben⁶, Tamas Koncz⁷, Sriram Krishnaswami⁵, Gene Wallenstein⁶, Samuel H. Zwillich⁵, Bethanie E. Wilkinson⁶ and the ORAL Start Investigators⁸, ¹Seoul National University, Seoul, South Korea, ²Metroplex Clinical Research Center, Dallas, TX, ³Cabrini Medical Centre, Melbourne, Australia, ⁴Karolinska Institute, Stockholm, Sweden, ⁵Pfizer Inc, Groton, CT, ⁶Pfizer Inc., Groton, CT, ⁷Pfizer Inc., New York, NY, ⁸Groton, CT
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. This Phase 3, 24-mo study (ORAL…
Abstract Number: 1568 • 2012 ACR/ARHP Annual Meeting
A Survey Study of Methotrexate Use by Rheumatologists and Their Patients with Rheumatoid Arthritis
Peter Nash¹ and Dave Nicholls², ¹University of Queensland, Brisbane, Australia, ²Coast Joint Care, Maroochydore, Australia
Background/Purpose: Methotrexate (MTX) is the anchor medication for the management of rheumatoid arthritis (RA); however there is limited patient-focused data available on the use of…
Abstract Number: 995 • 2012 ACR/ARHP Annual Meeting
Genetic Effects of HLA-DRB1, IL4R, and FcγRIIb On Long-Term Treatment Responses in Patients with Early Rheumatoid Arthritis: 78-Week Results of a Phase 4 Study
Alla Skapenko¹, Josef S. Smolen², Arthur Kavanaugh³, Vipin Arora⁴, Hartmut Kupper⁵ and Hendrik Schulze-Koops⁶, ¹Division of Rheumatology and Clinical Immunology, Med. Poliklinik,, University of Munich, Munich, Germany, ²Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ³UCSD School of Medicine, La Jolla, CA, ⁴Health Outcomes Research, Abbott, Abbott Park, IL, ⁵Immunology Development, Abbott GmbH and Co. KG, Ludwigshafen, Germany, ⁶University of Munich, Munich, Germany
Background/Purpose: Previous analyses suggested that the HLA-DRB1 shared epitope (SE), and the IL4R V50I and the FcγRIIb I232T single nucleotide polymorphisms (SNPs) affected response to…
Abstract Number: 371 • 2012 ACR/ARHP Annual Meeting
Treat-to-Target Strategy Aiming At Achievement of Structural and Functional Remission in Patients with Active Elderly-Onset Rheumatoid Arthritis
Takahiko Sugihara¹, Tatsuro Ishizaki², Tadashi Hosoya¹, Shoko Iga¹, Waka Yokoyama¹, Fumio Hirano¹, Nobuyuki Miyasaka³ and Masayoshi Harigai⁴, ¹Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ²Human Care Research Team, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan, ³Department of Medicine and Rheumatology and Global Center of Excellence Program, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Dept of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Treat-to-target is the consensus treatment strategy for patients with rheumatoid arthritis (RA), but supporting evidence for treat-to-target strategy in elderly RA patients in clinical…
Abstract Number: 2489 • 2012 ACR/ARHP Annual Meeting
Selective JAK1 Inhibition in the Treatment of Rheumatoid Arthritis: Proof of Concept with GLPG0634
Frédéric Vanhoutte¹, Minodora Mazur², Annegret Van der Aa¹, Piet Wigerinck¹ and Gerben van 't Klooster¹, ¹Galapagos NV, Mechelen, Belgium, ²Rheumatology, State Medical and Pharmaceutical University "Nicolae Testemitanu", Chisinau, Moldova
Background/Purpose: Janus kinases (JAKs) are critical components in signaling pathways for a number of cytokines and growth factors, including those involved in the disease process…
Abstract Number: 1316 • 2012 ACR/ARHP Annual Meeting
Long-Term Safety and Efficacy of 4-Weekly Certolizumab Pegol Combination and Monotherapy in Rheumatoid Arthritis: 5 Year Results from an Open Label Extension Study
Roy Fleischmann¹, Ronald F. van Vollenhoven², Jiri Vencovsky³, Rieke Alten⁴, Owen Davies⁵, Christian Stach⁶, Marc de Longueville⁷, Brenda Van Lunen⁸ and Ernest Choy⁹, ¹University of Texas Southwestern Medical Center at Dallas, Dallas, TX, ²Karolinska Institute, Stockholm, Sweden, ³Institute of Rheumatology, Prague, Czech Republic, ⁴Teaching Hospital of the Charité, University of Berlin, Berlin, Germany, ⁵UCB Pharma, Slough, United Kingdom, ⁶UCB Pharma, Monheim, Germany, ⁷Global Medical Affairs, UCB Pharma, Brussels, Belgium, ⁸UCB Pharma, Raleigh, NC, ⁹Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Certolizumab pegol (CZP) has been shown to be efficacious and have an acceptable safety profile when administered every 4 weeks (Q4W) as monotherapy (FAST4WARD,…
Abstract Number: 996 • 2012 ACR/ARHP Annual Meeting
Genetic Predictors of Methotrexate Efficacy and Toxicity in Early Rheumatoid Arthritis: Results From the Treatment of Early Aggressive Rheumatoid Arthritis Trial
Stella Aslibekyan¹, Elizabeth Brown², Richard J. Reynolds³, David T. Redden⁴, Sarah L. Morgan⁵, Joseph Baggott¹, Jin Sha¹, Larry W. Moreland⁶, James R. O'Dell⁷, Jeffrey R. Curtis⁸, S. Louis Bridges Jr.⁹ and Donna K. Arnett¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Univ of Alabama at Birmingham, Birmingham, AL, Birmingham, AL, ³Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, ⁸Rheumatology & Immunology, Univ of Alabama-Birmingham, Birmingham, AL, ⁹Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Methotrexate (MTX) has emerged as first-line therapy for early moderate to severe rheumatoid arthritis (RA), but individual variation in treatment efficacy and toxicity remains…
Abstract Number: 373 • 2012 ACR/ARHP Annual Meeting
Patient-Reported Outcomes in Early Rheumatoid Arthritis Patients Failing to Achieve Stable Low Disease Activity: Comparing Addition of Adalimumab to Methotrexate Monotherapy with Maintenance On Adalimumab Plus Methotrexate
Arthur Kavanaugh¹, Ronald F. van Vollenhoven², Paul Emery³, James W. Shaw⁴, Mary A. Cifaldi⁵, Stefan Florentinus⁶ and Josef S. Smolen⁷, ¹UCSD School of Medicine, La Jolla, CA, ²Karolinska Institute, Stockholm, Sweden, ³Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁴Global Health Economics and Outcomes Research, Abbott Laboratories, Abbott Park, IL, ⁵Abbott Laboratories, Abbott Park, IL, ⁶AbbVie, Rungis, France, ⁷Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: Treat-to-target guidelines for rheumatoid arthritis (RA) suggest adjusting therapy every 3-6 months for pts who fail to achieve a disease activity target. However, pts…

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