ACR Meeting Abstracts

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Abstracts tagged "treatment"

  • Abstract Number: 1978 • 2013 ACR/ARHP Annual Meeting

    The Effect Of Certolizumab On Lymphatic Volume and Flow In Rheumatoid Arthritis Patients With Acute Flare

    Homaira Rahimi1, Vaseem Chengazi2, Gregory Dieudonne2, Edward M. Schwarz3 and Christopher T. Ritchlin4, 1Pediatrics, University of Rochester, Rochester, NY, 2Radiology, University of Rochester, Rochester, NY, 3Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 4Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY

    Background/Purpose: Episodic flare occurs in rheumatoid arthritis (RA) but the mechanisms of this process are not well understood. Our prior reports on MRI analysis of…
  • Abstract Number: 802 • 2013 ACR/ARHP Annual Meeting

    Tofacitinib, An Oral Janus Kinase Inhibitor: Analysis Of Malignancies Across The Rheumatoid Arthritis Clinical Program

    X. Mariette1, J. R. Curtis2, E. B. Lee3, B. Benda4, I. Kaplan5, K. Soma5, R. Chew5, J. Geier6, L. Wang7 and R. Riese5, 1Paris-Sud University, Paris, France, 2Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Collegeville, PA, 5Pfizer Inc, Groton, CT, 6Pfizer Inc, New York, NY, 7Pfizer Worldwide R&D, Cambridge, MA

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). This analysis extended the evaluation of malignancies that occurred…
  • Abstract Number: 1862 • 2013 ACR/ARHP Annual Meeting

    Target-Directed Development Of a Proposed Biosimilar Etanercept, GP2015: Comparability Of In Vitro Target Binding and Pre-Clinical Efficacy and Pharmacokinetics

    Antonio da Silva1, Ulrich Kronthaler1, Cornelius Fritsch2, Johann Poetzl3, Adelheid Rohde4, Anastassia Papandrikopoulou5, Hans-Peter Hofmann6 and Jan Marinus Visser1, 1Preclinical Development, Sandoz Biopharmaceuticals / HEXAL AG, Holzkirchen, Germany, 2Bioassay Support Global Development, Novartis Pharma AG, Basel, Switzerland, 3Bioanalytics, Sandoz Biopharmaceuticals/Hexal AG, Oberhaching, Germany, 4Characterisation, Sandoz Biopharmaceuticals/Hexal AG, Kundl, Austria, 5Medical Communications, Sandoz Biopharmaceuticals / HEXAL AG, Holzkirchen, Germany, 6Pre-clinical, Sandoz Biopharmaceuticals/Hexal AG, Holzkirchen, Germany

    Background/Purpose: Biosimilars are copy versions of existing biologic medicines that have lost patent exclusivity and are approved via stringent regulatory pathways. Biosimilars are designed to…
  • Abstract Number: 463 • 2013 ACR/ARHP Annual Meeting

    An Indirect Comparisons Analysis Between Biologic Disease Modifiers in The Treatment Of Rheumatoid Arthritis To Evaluate For Efficacy and Safety

    Aaron C. Garza Romero1, Elie Donath1, Hernan Osorno1 and Suresh Kumar2, 1Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, FL, 2Rheumatology, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, FL

    Background/Purpose: There are primarily six groups of biologic disease modifiers (BDM) for treatment of rheumatoid arthritis (RA): tumor necrosis factor inhibitors (infliximab (IFX), etanercept (ETN),…
  • Abstract Number: 2802 • 2013 ACR/ARHP Annual Meeting

    A Treat-To-Target Strategy With Methotrexate and Intra-Articular Triamcinolone With Or Without Added Adalimumab Reduces Synovitis, Osteitis and Tenosynovitis and Halts Structural Damage Progression In Early Rheumatoid Arthritis: The Opera Magnetic Resonance Imaging Sub-Study

    Mette Bjørndal Axelsen1,2, Iris Eshed3, Kim Hørslev-Petersen4, Kristian Steengaard-Petersen5, Merete L. Hetland6, Jakob M. Møller7, Peter Junker8, Jan Pødenphant9, Torkell Ellingsen10, Palle Ahlquist11, Hanne M. Lindegaard12, Asta Linauskas13, Annette Schlemmer14, Mette Yde Dam15, Ib Hansen16, Hans Chr Horn17, Christian G. Ammitzbøll18, Anette Jørgensen19, Sophine B. Krintel20, Johnny Raun21, Julia S. Johansen22, Niels Steen Krogh23 and Mikkel Østergaard6, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 2Faculty of Health Sciences, Clinical Department of Orthopedics and Internal Medicine, Copenhagen University, Copenhagen, Denmark, 3Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel, 4King Christian 10th Hospital for Rheumatic Diseases, South Jutland Hospital, Graasteen, Denmark, 5Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 6Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 7Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, 8Odense University Hospital, Odense, Denmark, 9Copenhagen University at Gentofte, Hellerup, Denmark, 10Department of Internal Medicine, Diagnostic Centre Region Hospital Silkeborg Denmark, 8600 Silkeborg, Denmark, 11Department of Internal Medicine, Vejle Regional Hospital, Vejle, Denmark, 12Department of Rheumatology, Odense University Hospital, Odense, Denmark, 13Vendsyssel Hospital, Hjørring, Denmark, 14Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 15Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark, 16Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 17Internal Medicine/Rheumatology, Odense University Hospital, Odense, Denmark, 18Arhus University Hospital, Aarhus, Denmark, 19Rheumatology, Arhus University Hospital, Aarhus, Denmark, 20Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, 21University of Southern Denmark, Graasten, Denmark, 22Department of Internal Medicine and Oncology, Herlev Hospital, Herlev, Denmark, 23ZiteLab ApS, Copenhagen, Denmark

    Background/Purpose: The aim was to investigate if a treat-to-target strategy with methotrexate and intra-articular glucocorticoid suppressed synovitis and osteitis, and halted structural damage progression in…
  • Abstract Number: 1865 • 2013 ACR/ARHP Annual Meeting

    Complement Activation and Anaphylatoxin Generation In Response To Staphylococcal Protein A Exposure: Ex Vivo and In Vivo Human Studies

    Edward Bernton1, Antonio Polley2, Susan Zondlo2, Lynne Mitchell3 and Dennis Hourcade3, 1Protalex Inc., Summit, NJ, 2QPS Holdings LLC, Newark, DE, 3Division of Rheumatology, Washington University School of Medicine, St. Louis, MO

    Background/Purpose: PRTX-100, a highly-purified GMP staphylococcal protein A (SpA), is currently in clinical trials treating patients with active rheumatoid arthritis (RA). It has been reported…
  • Abstract Number: 465 • 2013 ACR/ARHP Annual Meeting

    Higher Titer Of Anti-Citrullinated Protein Antibodies In Biologic-Naïve Rheumatoid Arthritis Patients Are Candidate Biomarkers To Predict Sensitivity Leading To Clinical Remission With Abatacept; Data From The Abroad Study

    Takao Fujii1, Masahiro Sekiguchi2, Kiyoshi Matsui2, Masayasu Kitano2, Motomu Hashimoto3, Koichiro Ohmura4, Aihiro Yamamoto5, Hideko Nakahara6, Keiji Maeda7, Akira Yokota8, Kenji Miki9, Naoki Shimmyo10, Takanori Kuroiwa11, Kosaku Murakami12, Yoshio Ozaki13, Kenshi Higami14, Ichiro Yoshii15, Yuji Nozaki16, Takashi Ikawa17, Satoshi Morita18, Yutaka Kawahito5, Norihiro Nishimoto19, Tsuneyo Mimori4 and Hajime Sano2, 1Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, 3The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 6Division of Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan, 7Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan, 8Yokota Clinic for Rheumatology, Osaka, Japan, 9Department of Orthopaedic Surgery, Amagasaki Central Hospital, Amagasaki, Japan, 10Kashiba Asahigaoka Hospital, Kashiba, Japan, 11Department of Rheumatology, Yukioka Hospital, Osaka, Japan, 12Dept of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 13Kansai Medical University Hirakata Hospital, Hirakata, Japan, 14Department of Rheumatology, Higami Hospital, Nara, Japan, 15Department of Orthopaedic Surgery, Yoshii Hospital, Shimanto, Japan, 16Kinki University Faculty of Medicine, Sayama, Japan, 17Osaka Rehabilitation Hospital, Hannan, Japan, 18Graduate School of Medicine & Medical Center, Department of Biostatistics and Epidemiology, Yokohama City University, Kanagawa, Japan, 19Osaka Rheumatology Clinic, Osaka, Japan

    Background/Purpose: Biomarkers to predict each rheumatoid arthritis (RA) patient’s sensitivity for biologic disease modifying anti-rheumatic diseases, especially for the only T cell modulator abatacept (ABT),…
  • Abstract Number: 2641 • 2013 ACR/ARHP Annual Meeting

    Earlier Admission To Specialized Care, Intensified Treatment and Improved Outcome In Patients With Autoimmune Connective Tissue Disorders and Vasculitides In Germany 2011 Compared To 1995

    Dörte Huscher1, Katinka Albrecht2, Katja Thiele2, Sascha Bischoff2, Jutta G. Richter3, Ina Kötter4, Wolfgang Ochs5 and Angela Zink1, 1German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, 2German Rheumatism Research Centre, Berlin, Germany, 3Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 4ZIRS, Centre for Interdisciplinary Rheumatology Stuttgart, Stuttgart, Germany, 5Rheumatologist in private practice, Bayreuth, Germany

    Background/Purpose: Compared to rheumatoid arthritis and other arthritis-associated rheumatic diseases, autoimmune connective tissue disorders and vasculitides are still in the early stages of biological therapies.…
  • Abstract Number: 1792 • 2013 ACR/ARHP Annual Meeting

    Inhibition Of Chemokine Receptors CCR1 and CCR6 As Promising Therapies For Autoimmune Diseases Such As Rheumatoid Arthritis and Psoriasis

    Daniel Dairaghi1, Penglie Zhang2, Manmohan Leleti2, Robert Berahovich3, Karen Ebsworth3, Linda Ertl3, Shichang Miao4, Zhenhua Miao3, Lisa Seitz3, Joanne Tan3, Matthew Walters3, Yu Wang3, Jay Powers5, Thomas J. Schall6 and Juan C. Jaen7, 1Biology, ChemoCentryx, Inc., Mountain View, CA, 2Chemistry, ChemoCentryx, Mountain View, CA, 3Biology, ChemoCentryx, Mountain View, CA, 4Pharmacokinetics, ChemoCentryx, Inc., Mountain View, CA, 5ChemoCentryx, Mountain View, CA, 6ChemoCentryx, Inc., Mountain View, CA, 7Discovery and Preclinical Development, ChemoCentryx, Inc., Mountain View, CA

    Background/Purpose:  Chemokines are key regulators of leukocyte activation and recruitment to sites of inflammation. Of particular relevance in rheumatoid arthritis (RA), the chemokine receptors CCR1…
  • Abstract Number: 469 • 2013 ACR/ARHP Annual Meeting

    Anti-TNF Therapy Induces Positive Changes In The Lipoprotein Profile Of RA Patientes. Results Of a Prospective Study

    Jaime Calvo-Alén1, Carmela Baamonde2, Ignacio Villa1, Víctor Martínez-Taboada3, Mario Agudo4 and Juan Gómez-Gerique5, 1Rheumatology, Hospital Universitario Sierrallana, Torrelavega, Spain, 2Biochemistry, Hospital Universitario Sierrallana, Torrelavega, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 5Biochemistry, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Background/Purpose: Anti-TNF therapy induces elevations in total cholesterol levels although does not seem to modify the atherogenic index. Otherwise, it appears to have a cardiovascular…
  • Abstract Number: 2381 • 2013 ACR/ARHP Annual Meeting

    The JAK1-Selective Inhibitor GLPG0634 Is Safe and Rapidly Reduces Disease Activity In Patients With Moderate To Severe Rheumatoid Arthritis; Results Of a 4-Week Dose Ranging Study

    Chantal Tasset, Pille Harrison, Annegret Van der Aa, Luc Meuleners, Frédéric Vanhoutte and Gerben van 't Klooster, Galapagos NV, Mechelen, Belgium

    Background/Purpose: GLPG0634 is an oral, selective inhibitor of Janus kinase 1 (JAK1). JAKs signal for cytokines and growth factors, including those involved in rheumatoid arthritis…
  • Abstract Number: 1793 • 2013 ACR/ARHP Annual Meeting

    Oskira-1: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study Of 2 Dosing Regimens Of Fostamatinib In Rheumatoid Arthritis Patients With An Inadequate Response To Methotrexate

    Michael Weinblatt1, Mark C. Genovese2, Meilien Ho3, Sally Hollis3, Krystyna Rosiak-Jedrychowicz4, Arthur Kavanaugh5, David Millson3, Gustavo Leon6, Millie Wang3 and Désiréé van der Heijde7, 1Division of Rheumatology, Brigham & Women's Hospital, Boston, MA, 2Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA, 3AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, 4Przychodnia Neuromedyka, Zyrardów, Poland, 5University of California, San Diego, La Jolla, CA, 6Instituto de Ginecología y Reproducción-Cirugía Mínimamente Invasiva, Surco, Peru, 7Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Fostamatinib (Fosta) is an oral SYK inhibitor. This 52-wk study (NCT01197521) compared Fosta vs placebo (PBO) + methotrexate (MTX) in patients (pts) with active…
  • Abstract Number: 473 • 2013 ACR/ARHP Annual Meeting

    Real-World Effectiveness and Safety Of Infliximab In The Treatment Of Rheumatoid Arthritis Over 5 Years: The Canadian Experience

    Denis Choquette1, William Bensen2, Andrew Chow3, John T. Kelsall4, Maqbool K. Sheriff5, Jude F. Rodrigues6, Emmanouil Rampakakis7, John S. Sampalis7, May Shawi8, Francois Nantel9, Susan M. Otawa10 and Allen J. Lehman10, 1Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 2St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, 3University of Toronto, McMaster University, Credit Valley Rheumatology, Mississauga, ON, Canada, 4Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, 5Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 6Rheumatology, Windsor, ON, Canada, 7JSS Medical Research, Montreal, QC, Canada, 8Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada, 9Janssen Inc., Toronto, ON, Canada, 10Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose:   Efficacy and safety of anti-TNF in rheumatoid arthritis (RA) management has been demonstrated in numerous controlled clinical trials. Longitudinal observational studies assessing the…
  • Abstract Number: 2490 • 2012 ACR/ARHP Annual Meeting

    Herpes Zoster and Tofacitinib Therapy in Patients with Rheumatoid Arthritis

    K. L. Winthrop1, H. Valdez2, E. Mortensen3, R. Chew4, S. Krishnaswami5, T. Kawabata5 and R. Riese4, 1Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, 2Pfizer Inc., New York, NY, 3Global Medical Affairs, Pfizer Inc., Collegeville, PA, 4Pfizer Inc., Groton, CT, 5Pfizer Inc, Groton, CT

    Background/Purpose: Patients (pts) with RA are at increased risk for herpes zoster (HZ) i.e. ‘shingles'. Tofacitinib, a novel oral Janus kinase inhibitor investigated as a…
  • Abstract Number: 1318 • 2012 ACR/ARHP Annual Meeting

    Long-Term Benefits of 4-Weekly Certolizumab Pegol Combination and Monotherapy On Household Productivity and Social Participation in Rheumatoid Arthritis: 5 Year Results from an Open Label Extension Study

    Vibeke Strand1, Oana Purcaru2, Ronald F. van Vollenhoven3, Ernest Choy4 and Roy Fleischmann5, 1Adjunct, Division of Immunology / Rheumatology, Stanford University, Portola Valley, CA, 2UCB Pharma, Brussels, Belgium, 3Karolinska Institute, Stockholm, Sweden, 4Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, 5Southwestern Medical Center at Dallas, University of Texas, Dallas, TX

    Background/Purpose: Certolizumab pegol (CZP) monotherapy administered every 4 weeks (Q4W) for rheumatoid arthritis (RA) has been shown to be associated with rapid and sustainable improvements…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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