ACR Meeting Abstracts

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Abstracts tagged "treatment"

  • Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting

    Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection

    Jason Ptacek, Ellen L. Berg and Alison O'Mahony, BioSeek, a division of DiscoveRx Corp., South San Francisco, CA

    Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…
  • Abstract Number: 611 • 2015 ACR/ARHP Annual Meeting

    The Rapid Kinetics of Optimal Treatment with Subcutaneous Methotrexate in Early Inflammatory Arthritis

    Anna O'Connor1, J Carter Thorne2, Diane Tin3 and Janet E. Pope4, 1Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 4Monsignor Roney Bldg/Rheum, University of Western Ontario, St Joseph Health Care, London, ON, Canada

    Background/Purpose: Methotrexate (MTX) is standard treatment in RA. Absorption is better in subcutaneous MTX (scMTX), which may impact speed of onset. In RA, earlier time…
  • Abstract Number: 2783 • 2015 ACR/ARHP Annual Meeting

    What Is the Rate of Primary and Secondary Failure of Anti-TNF in RA Patients? Data from a Rheumatoid Arthritis Cohort

    Edward C. Keystone1, Mohammad Movahedi2,3, Angela Cesta2, Xiuying Li2, Sandra Couto2, Emmanouil Rampakakis3, John S. Sampalis3,4, Claire Bombardier2,5,6 and OBRI Investigators, 1The Rebecca MacDonald Centre For Arthritis, Mount Sinai Hospital, Toronto, ON, Canada, 2Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 3JSS Medical Research, St-Laurent, QC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Toronto, Department of Medicine (DOM) and Institute of Health Policy Management, and Evaluation (IHPME), Toronto, ON, Canada, 6Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Although the majority of RA patients respond to treatment with anti-TNF agents, some patients present with refractory disease (1ry failure) while others show some…
  • Abstract Number: 969 • 2015 ACR/ARHP Annual Meeting

    Namilumab, an Anti-Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Monoclonal Antibody: Results of the First Study in Patients with Mild-to-Moderate Rheumatoid Arthritis (RA)

    T. W. J. Huizinga1, Anastas Batalov2, Rumen Stoilov3, Eric Lloyd4, Thomas Wagner5, Didier Saurigny6, Bernard Souberbielle6 and Ehsanollah Esfandiari6, 1Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2UMHAT Kaspela, Plovdiv, Bulgaria, 3University Hospital (MHAT) St Ivan Rilski, Sofia, Bulgaria, 4Takeda Pharmaceuticals, Deerfield, IL, 5Takeda Pharmaceuticals, Zurich, Switzerland, 6Takeda Pharmaceuticals, London, United Kingdom

    Background/Purpose: GM-CSF mediates a range of immunological processes, such as stimulating the production of inflammatory mediators and differentiation of proinflammatory T-helper 17 cells, and may…
  • Abstract Number: 3194 • 2015 ACR/ARHP Annual Meeting

    Oral to Subcutaneous Methotrexate Dose-Conversion Strategies in the Treatment of Rheumatoid Arthritis

    Michael Schiff1 and Peter Sadowski2, 1Division of Rheumatology, University of Colorado, Denver, CO, 2Antares Pharma Inc., Minneapolis, MN

    Background/Purpose: Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) therapy1 but absorption saturation limitations compromise oral MTX bioavailability (BA). Subcutaneous (SC) MTX has a…
  • Abstract Number: 970 • 2015 ACR/ARHP Annual Meeting

    Efficacy and Safety of Sarilumab in Combination with Csdmards in Patients with Active Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant of Anti–TNF-α Therapy: Results from a Phase 3 Study

    Roy Fleischmann1, Geraldo Castelar-Pinheiro2, Jan Brzezicki3, Pawel Hrycaj4, Yong Lin5, Janet van Adelsberg6, Neil Graham7, Hubert van Hoogstraten5, Deborah Bauer5 and Gerd Burmester8, 1University of Texas Southwestern Medical Center, Dallas, TX, 2Discipline of Rheumatology, Rio de Janeiro State University, Rio de Janeiro, Brazil, 3Centrum Kliniczno-Badawcze, Elblag, Poland, 4Poznan University of Medical Sciences, Poznan, Poland, 5Sanofi, Bridgewater, NJ, 6Clinical Science, Regeneron Pharmaceutials, Inc., Tarrytown, NY, 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 8Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: The investigational agent sarilumab is a human mAb directed against the IL-6 receptor. The phase 3 MOBILITY study (NCT01061736) evaluated the efficacy and safety…
  • Abstract Number: 3243 • 2015 ACR/ARHP Annual Meeting

    A Randomized Controlled Trial for a Physical Activity Intervention for RA Fatigue

    Patricia P. Katz1, Mary Margaretten2, Steven Gregorich1, Sandi Kaplan3, Stephanie Rush4 and Laura Trupin1, 1Medicine, University of California San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, San Francisco, CA, 3Arthritis Research Group, University of California, San Francisco, CA, 4University of California, San Francisco, San Francisco, CA

    Background/Purpose: Fatigue is a major problem for people with RA.  Physical inactivity is an indirect risk factor for fatigue1. We tested the effect of a…
  • Abstract Number: 1280 • 2015 ACR/ARHP Annual Meeting

    Comparison of Health Service Utilization Costs Between Aboriginal and Non-Aboriginal Patients with Rheumatoid Arthritis Requiring Biologic Therapy

    Cheryl Barnabe1, Yufei Zheng2, Arto Ohinmaa2, Brenda Hemmelgarn3, Gilaad Kaplan4, Liam Martin5 and Walter Maksymowych6, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2Institute of Health Economics, Edmonton, AB, Canada, 3Division of Nephrology, University of Calgary, Calgary, AB, Canada, 4Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, 5Medicine, University of Calgary, Calgary, AB, Canada, 6Medicine, Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Logistical issues and poor cultural environments in tertiary care create barriers to specialized care for Aboriginal patients with rheumatoid arthritis (RA). Aboriginal patients are…
  • Abstract Number: 1318 • 2015 ACR/ARHP Annual Meeting

    Prediction of Large Joint Destruction in Patients with Rheumatoid Arthritis Using FDG-PET/CT: A Prospective Study

    Takahito Suto, Koichi Okamura, Yukio Yonemoto, Chisa Okura and Kenji Takagishi, Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Background/Purpose: The assessments of joint damage in patients with rheumatoid arthritis (RA) are mainly restricted to small joints in the hands and feet. However, the…
  • Abstract Number: 1438 • 2015 ACR/ARHP Annual Meeting

    Oral Potassium (K+) Reduces Pain in RA: A Randomized Active Control Study of Diet Based K+ Intervention

    Toktam Kainifard1, Manjit Saluja2, Anuradha Venugopalan3, Raju Rane4 and Arvind Chopra5, 1Rheumatology, PhD fellow, Pune, India, 2Clinical care, Center for Rheumatic Diseases, Pune, India, 3Rheumatology, R & D, Lab, Center for Rheumatic Diseases, Pune, India, 4Pathology, Pathologist, Pune, India, 5Rheumatology, Centre for Rheumatic Diseases, Pune 411001, India

    Background/Purpose: National Health and Nutrition Survey III (1988-94,USA) data showed a low K+ body status in RA. Further information is scanty. K+ is critical to…
  • Abstract Number: 1632 • 2015 ACR/ARHP Annual Meeting

    Do RA Susceptibility Loci Predict Response to Methotrexate As First DMARD in Early RA?

    Thomas Frisell1, Saedis Saevarsdottir2,3 and Johan Askling1,4, 1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Improved means to predict which RA patients will respond to methotrexate monotherapy, the preferred first line therapy in early RA, would allow patients to…
  • Abstract Number: 1647 • 2015 ACR/ARHP Annual Meeting

    A Randomized, Clinical Trial to Assess the Relative Efficacy and Tolerability of Two Doses of Etoricoxib in Patients with Rheumatoid Arthritis

    Kara Bickham1, Désirée van der Heijde2, Narinder Rawal3, Joachim Sieper4, Boyd Scott5, Nancy Frontera1, Sandhya Shah1, Paul Stryszak1, Dimitris Papanicolaou1, Zoran Popmihajlov1 and Paul Peloso1, 1Merck & Co., Inc., Kenilworth, NJ, 2University Hospital, Maastricht, Netherlands, 3Orebro University Hospital, Orebro, Sweden, 4Rheumatology, Charite - Campus Benjamin Franklin, Berlin, Germany, 5Merck Sharp & Dohme Corp., Whitehouse Station, NJ

    Background/Purpose: Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, provides symptom modification in RA patients. Previous dose-ranging studies in RA demonstrated the clinical efficacy of etoricoxib 90…
  • Abstract Number: 1659 • 2015 ACR/ARHP Annual Meeting

    Lack of Effect of Reduced Folic Acid Supplementation on Disease Activity in RA

    Lisa K. Stamp1, Jill Drake2, John L. O'Donnell3, Christopher Frampton4 and Peter T. Chapman5, 1Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 2Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand, 3Immunology, Canterbury Health Laboratories, Christchurch, New Zealand, 4University of Otago, Christchurch, Christchurch, New Zealand, 5Rheumatology, Christchurch Hospital, Christchurch, New Zealand

    Background/Purpose: It is recommended that all patients receiving MTX also receive at least 5mg/week of folic acid in an effort to reduce occurrence of MTX…
  • Abstract Number: 1660 • 2015 ACR/ARHP Annual Meeting

    Two-Year Prospective Study of Patients with Rheumatic Disease on Dose Reduction of Biological Therapy

    M. Victoria Hernández1, Jose Inciarte-Mundo2, Sonia Cabrera-Villalba3, Virginia Ruiz-Esquide4, Julio Ramirez2, Andrea Cuervo4, Juan D. Cañete4,5 and Raimon Sanmarti2, 1Arthritis Unit, Rheumatology, Hospital Clinic, Barcelona, Spain, 2Arthritis Unit. Rheumatology, Hospital Clínic of Barcelona, Barcelona, Spain, 3Rheumatology Department, Hospital Clinic i Provincial, Barcelona, Spain, 4Arthritis Unit. Rheumatology, Hospital Clínic, Barcelona, Spain, 5Hospital Clinic, Barcelona, Arthritis Unit, Rheumatology Department, Barcelona, Spain

    Background/Purpose: Dose reduction of biological therapy in patients with chronic arthritis (CA) with good clinical response is a common pattern in clinical practice. However, most…
  • Abstract Number: 1665 • 2015 ACR/ARHP Annual Meeting

    Treatment Patterns in Rheumatoid Arthritis after Methotrexate: Data from a Rheumatoid Arthritis Cohort

    Janet E. Pope1, Mohammad Movahedi2,3, Angela Cesta2, Xiuying Li2, Sandra Couto2, Emmanouil Rampakakis3, John S. Sampalis3,4, Claire Bombardier2,5,6 and OBRI Investigators, 1University of Western Ontario, London, ON, Canada, 2Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 3JSS Medical Research, St-Laurent, QC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Toronto, Department of Medicine (DOM) and Institute of Health Policy Management, and Evaluation (IHPME), Toronto, ON, Canada, 6Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Guidelines support the use of combination conventional synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs), switching csDMARDs and/or use of biologic DMARDs (bDMARDs) treatment in active rheumatoid…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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