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Abstracts tagged "treatment and pharmacokinetics"

  • Abstract Number: 2401 • 2019 ACR/ARP Annual Meeting

    Enhanced Methotrexate Polyglutamation in Japanese as Compared to Caucasian Rheumatoid Arthritis Patients Starting Methotrexate

    Thierry Dervieux1, Joel Kremer 2, Kelley Brady 1, Chihiro Takahashi 3, Tsutomu Takeuchi 4 and Yuko Kaneko 5, 1Exagen, Vista, CA, 2Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY, 3Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, 4Keio University Hospital Division of Rheumatology, Tokyo, Japan, 5Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan

    Background/Purpose: Methotrexate (MTX) is an anti-folate prodrug activated to MTX polyglutamates (MTXPGs). Japanese Rheumatoid Arthritis (RA) patients are thought to have heightened sensitivity to MTX…
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ACR Pediatric Rheumatology Symposium 2020

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