Abstracts tagged "Traps and mitochondria"

Abstract Number: 1160 • 2013 ACR/ARHP Annual Meeting
Oxidative Stress As a Disease Marker and Therapeutic Target In Patients With Tumor Necrosis Factor Receptor Associated Periodic Fever Syndrome
Cornelia Cudrici¹, Ariel Bourla¹, Martin Pelletier², Leah Billingham¹, Amanda K. Ombrello³, Michael Murphy⁴, Daniel L. Kastner⁵ and Richard M. Siegel⁶, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Niams, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ³National Human Genome Research Institute,National Institute of Health, Bethesda, MD, ⁴Medical research council mitochondria biology unit Cambridge ,UK, Cambridge, United Kingdom, ⁵Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ⁶National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

Background/Purpose: TRAPS (Tumor necrosis factors receptor associated periodic fever syndrome) is an autosomal dominant autoinflammatory disease associated with missense mutations in TNFRSF1A (tumor necrosis factor…

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