ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Transforming Growth Factor (TGF)"

  • Abstract Number: 0280 • ACR Convergence 2021

    Mast Cells Contribute to the Development of Lung Fibrosis via Inducing Myofibroblast Differentiation by TGF-β Production

    Shinjiro Kaieda1, Masaki Okamoto2, Masaki Tominaga1 and Tomoaki Hoshino1, 1Kurume University School of Medicine, Kurume, Japan, 2Kyushu Medical Center, Fukuoka, Japan

    Background/Purpose: Idiopathic pulmonary fibrosis is an interstitial lung disease of unknown etiology. The most critical event in the evolution of fibrosis is the appearance of…
  • Abstract Number: 1917 • ACR Convergence 2021

    Sputum TGF-β1 Is Elevated in Subclinical and Clinically Significant Rheumatoid Arthritis-Associated Interstitial Lung Disease and Correlates with Soluble IL-6R Levels

    Timothy Wilson1, Kevin Deane2, Joyce Lee1, Christopher Collora3, Marie Feser3, Mariana Kaplan4, Joshua Solomon5 and Kristen Demoruelle6, 1University of Colorado, Denver, CO, 2University of Colorado Denver, Denver, CO, 3University of Colorado Denver, Aurora, CO, 4National Institutes of Health, Bethesda, MD, 5National Jewish Health, Denver, CO, 6University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Increased levels of transforming growth factor β1 (TGF-β1) in the lung have been implicated in the pathogenesis of several fibrotic lung diseases, but their…
  • Abstract Number: 0374 • ACR Convergence 2020

    Neo-epitopes of Type I Collagen Can Be Utilized as Translational Biomarkers for Skin and Joint Turnover in Patients with Psoriasis and Psoriatic Arthritis

    Solveig S. Groen1, Signe Holm Nielsen2, Conor Magee3, Anne Sofie Siebuhr4, Anne C. Bay-Jensen2, Morten A. Karsdal4, Stephen Pennington5 and Oliver FitzGerald6, 1University of Copenhagen, Copenhagen, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3St Vincent's University Hospital and the UCD Conway Institute, University College Dublin, Dublin, Ireland, 4Nordic Bioscience A/S, Herlev, Denmark, 5University College Dublin, Dublin, Dublin, Ireland, 6Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Psoriasis (PsO) is a chronic immune-mediated skin disease. Around 30% of patients diagnosed with PsO will develop psoriatic arthritis (PsA). Patients with PsA may…
  • Abstract Number: 0395 • ACR Convergence 2020

    African Ancestry-Specific Variants Regulate TGFB3 Expression in Systemic Sclerosis

    Julia Hartman1, Andrea Conte2, Chloe Borden3, Urvashi Kaundal4, Yongbing Zhao2, Sarah Safran5, Ami Shah6, Maureen Mayes7, Ayo Doumatey8, Amy Bentley9, Daniel Shriner8, Robyn Domsic10, Thomas Medsger11, Paula Ramos12, Richard Silver13, Virginia Steen14, John Varga15, Vivien Hsu16, Lesley Ann Saketkoo17, Elena Schiopu18, Dinesh Khanna19, Jessica Gordon20, Lindsey Criswell21, Heather Gladue22, Chris Derk23, Elana Bernstein24, S. Louis Bridges25, Victoria Shanmugam26, Kathleen Kolstad27, Lorinda Chung28, Suzanne Kafaja29, Reem Jan30, Marcin Trojanowski31, Avram Goldberg32, Benjamin Korman33, Monique Hinchcliff34, Settara Chandrasekharappa8, Stefania Dell'Orso3, Adebowale Adeyemo8, Charles Rotimi8, Elaine Remmers35, Fredrick Wigley36, Daniel Kastner35, Francesco Boin37, Rafael Casellas2 and Pravitt Gourh4, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Washington, DC, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, New York, NY, 6Johns Hopkins University School of Medicine, Ellicott City, MD, 7University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, 8National Human Genome Research Institute, Bethesda, 9National Human Genome Research Institute (NHGRI), NIH, Bethedsa, MD, 10University of Pittsburgh School of Medicine, Pittsburgh, PA, 11University of Pittsburgh School of Medicine, Verona, PA, 12Medical University of South Carolina, Charleston, SC, 13Medical University of South Carolina, Charleston, 14Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 15Northwestern University, Chicago, IL, 16Rutgers-RWJ Medical School, South Plainfield, NJ, 17Scleroderma Patient Care and Research Center, Tulane University, New Orleans, LA, 18Michigan Medicine, Ann Arbor, MI, 19University of Michigan, Ann Arbor, MI, 20Hospital for Special Surgery, New York, NY, 21Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA, 22Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, 23University of Pennsylvania, Philadelphia, PA, 24Columbia University, New York, NY, 25University of Alabama at Birmingham, Mountain Brk, AL, 26The George Washington University, Washington, DC, 27Division of Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 28Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA, 29David Geffen School of Medicine, UCLA, Los Angeles, CA, 30Pritzker School of Medicine, University of Chicago, Chicago, IL, 31Boston University Medical Center, BOSTON, MA, 32NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 33Department of Medicine, University of Rochester Medical Center, Rochester, NY, 34Yale School of Medicine, Westport, CT, 35National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD, 36Johns Hopkins University School of Medicine, Baltimore, MD, 37University of California San Francisco, Cedars-Sinai, West Hollywood, CA

    Background/Purpose: African American (AA) patients have a higher prevalence of SSc than European Americans (EA). Adding to this health disparity, AA SSc patients are more…
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ACR Pediatric Rheumatology Symposium 2020

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