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Abstracts tagged "transcriptome"

  • Abstract Number: 2809 • ACR/ARP Annual Meeting 2019

    Single-Cell RNA Sequencing of Murine Neutrophils Identifies a Transcriptional Continuum (“Neutrotime”) Across Biological Compartments

    Ricardo Grieshaber-Bouyer1, Giuseppina Stifano 2, Pierre Cunin 3, Anaïs Levescot 4, Nathan Nelson-Maney 4, Rachel Blaustein 5, Paul Monach 6, Peter Nigrovic 7 and ImmGen Consortium 8, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, 2Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 3Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 4Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, 5Brigham and Women's Hospital, Boston, 6Brigham and Women's Hospital, Boston, MA, 7Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston, 8Harvard Medical School, Boston

    Background/Purpose: Neutrophils are key first responders of innate immunity, participating in both defense and inflammatory disease. Phenotypic heterogeneity is recognized but the existence of bone…

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