ACR Meeting Abstracts

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Abstracts tagged "Tissue Engineering"

  • Abstract Number: 0016 • ACR Convergence 2024

    Establishment of a Human 3D In-Vitro Lymphoid Model to Evaluate Germinal Center Biology

    Lichchavi Rajasinghe1, Govinda Rocky Thomas,2, Jee Ho Lee1, Gary Sims1 and Tatiana Ort1, 1Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 2AstraZeneca Pharmaceuticals, Gaithersburg, MD

    Background/Purpose: Germinal centers (GC) are specialized lymphoid structures found within the B cell follicles of secondary lymphoid tissue formed following infection or immunization. They are…
  • Abstract Number: 1751 • ACR Convergence 2024

    Precision Targeting of Autoreactive 9G4 B Cells in Systemic Lupus Erythematosus Using Engineered Chimeric Antigen Receptor (CAR)- and Chimeric T Cell Receptor (cTCR)-T Cells

    Jin Liu1, Brian Mog1, Yuanxuan Xia1, Elana Shaw1, Alexander Pearlman1, Dylan Ferris1, Kyle J. Kaeo1, Colin Gliech1, Tolulope Awosika1, Brock Moritz1, Tushar Nichakawade1, Yang Li1, Stephanie Glavaris1, Sarah DiNapoli1, Nikita Marcou1, Taha Ahmedna1, Victoria Duarte Alvarado1, Denis Wirtz1, Regina Bugrovsky2, Scott A. Jenks2, Iñaki Sanz3, Daniel Goldman4, Michelle Petri4, Chetan Bettegowda1, Suman Paul1, Kenneth W. Kinzler1, Shibin Zhou1, Felipe Andrade5, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Emory University School of Medicine, Atlanta, GA, 3Emory University School of Medicine, Atlanta, 4Johns Hopkins University School of Medicine, Timonium, MD, 5The Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: The autoreactive B cell compartment in systemic lupus erythematosus (SLE) is characterized by expansion of B cells expressing immunoglobulin heavy variable gene 4-34 (IGHV4-34)…
  • Abstract Number: 2300 • ACR Convergence 2024

    Activation of Tissue-Resident T Cells in Sjögren’s Disease with Human Salivary Organoids

    Brandon Law1, Rahmatullah Rahmati2 and Andrew Luster3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts Eye & Ear, Boston, MA, 3Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, particularly the salivary glands. These focal lymphocytic infiltrates are…
  • Abstract Number: 1769 • ACR Convergence 2023

    TNF-Stimulated Production of IL-15 by Fibroblast-Like Synoviocytes Mediates Human Resident Memory T Cells Development in Synovial Organoid Model

    Margaret Chang1, Maryrose Hahn2, Madison Mangin1, Brian Wauford1, Rachel Blaustein3, Lauren Henderson1, Kevin Wei4 and Peter Nigrovic1, 1Boston Children's Hospital, Boston, MA, 2Division of Immunology, Boston Children's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are chronic autoimmune diseases that tend to flare repeatedly in the same joints, displaying joint-specific memory.…
  • Abstract Number: 2181 • ACR Convergence 2023

    Secretagogue Effect of PDE4 Inhibitor Apremilast on Human Salivary Gland Organoids Obtained from Primary Sjögren’s Syndrome Patients

    Valeria Manfrè1, Salvatore Parisi2, Isabella Caligiuri2, Ombretta Repetto3, Alen Zabotti1, Enrico Pegolo4, Cinzia Fabro1, Salvatore De Vita1, Vincenzo Canzonieri2, Carla Di Loreto4, Flavio Rizzolio2 and Luca Quartuccio1, 1Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, 2Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, 3Facility of Bio-Proteomics, Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, 4Institute of Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o Università degli studi di Udine, Udine, Italy

    Background/Purpose: In primary Sjögren's syndrome (pSS), salivary epithelial cells show an active role in the initiation and reiteration of the immunomediated damage. Epithelial saliva production…
  • Abstract Number: 2184 • ACR Convergence 2023

    Development of Salivary Gland Organoids to Study Sjögren Syndrome

    Loïc Meudec1, Negaar Goudarzi2, Juliette Pascaud3, Fanny Jaulin2, Xavier Mariette4 and Gaetane Nocturne5, 1CHU Kremlin-Bicêtre, Rheumatology, Le Kremlin-Bicêtre, France, 2INSERM UMR 981, Institut Gustave Roussy, Villejuif, France, Villejuif, France, 3Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, FHU CARE, Université Paris-Saclay, Le Kremlin-Bicêtre, France, 4Université Paris-Saclay, Le Kremlin-Bicêtre, France, 5APHP, Le Kremlin-Bicêtre, France

    Background/Purpose: Sjögren disease (Sjo) is an autoimmune disease characterized by the infiltration of exocrine glands by immune cells, especially salivary glands (SG). SG epithelial cells…
  • Abstract Number: 020 • 2023 Pediatric Rheumatology Symposium

    Generation of Human Resident Memory T Cells in 3D Synovial Organoid Model

    Margaret Chang1, Maryrose Hahn1, Brian Wauford1, Rachel Blaustein2, Kevin Wei2 and Peter Nigrovic1, 1Boston Children's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Most rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients experience episodic arthritis flares and require life-long medications to control their disease. We observed…
  • Abstract Number: 023 • 2023 Pediatric Rheumatology Symposium

    Effect of Type 1 Interferons and JAK Inhibitors on Gene Expression in Bioengineered Pediatric Skeletal Muscle

    Lauren Covert1, Joseph Prinz2, Hailee Patel3, Jeffrey Dvergsten4 and George Truskey3, 1Duke University, Durham, NC, 2Duke University School of Medicine, Department of Biostatistics and Bioinformatics, Durham, NC, 3Duke University, Department of Biomedical Engineering, Durham, NC, 4Duke University Hospital, Durham, NC

    Background/Purpose: Genetic studies of new-onset juvenile dermatomyositis (JDM) exhibit elevation of Type 1 interferons (IFN 1) IFNα and IFNβ in blood, skin, and muscle. To…
  • Abstract Number: 1173 • ACR Convergence 2022

    Single-cell Multi-omic Analysis of a 3D Skin-Like Tissue Model Provides Insights into Molecular and Cellular Drivers of Systemic Sclerosis

    Tamar Abel1, Noelle Kosarek2, Rezvan Parvizi3, Helen Jarnagin1, Mengqi Huang4, Avi Smith5, Michael Mariani1, Dillon Popovich6, Heetaek Yang7, Tammara Wood8, Jonathan Garlick9, Patricia Pioli7 and Michael Whitfield10, 1Dartmouth College, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Dartmouth, Lebanon, NH, 4University of Pittsburgh, Pittsburgh, PN, 5Tufts University, Boston, MA, 6Dartmouth College, West Lebanon, NH, 7Geisel School of Medicine at Dartmouth, Lebanon, NH, 8Dartmouth College, Hanover, NH, 9Tufts University School of Dental Medicine, Boston, MA, 10Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Systemic Sclerosis (SSc) currently lacks reliable in vitro models of skin fibrosis constructed from all human cells. We have developed a skin-like tissue model of systemic…
  • Abstract Number: 1677 • ACR Convergence 2022

    Chimeric Autoantigen-T Cell Receptor (CATCR)-T Cell Therapies to Selectively Target Autoreactive B Cells

    Brian J. Mog1, Elana R. Shaw1, Michael S. Hwang1, Alexander H. Pearlman1, Sarah R. DiNapoli1, Suman Paul1, Chetan Bettegowda1, Nickolas Papadopoulos1, Sandra B. Gabelli1, Michelle Petri2, Antony Rosen1, Shibin Zhou1, Kenneth W. Kinzler1, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of cancer and can be curative. CD19-targeted CAR-T cells hold promise for the treatment…
  • Abstract Number: 0030 • ACR Convergence 2022

    Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease

    Alexandra Damerau1, Duc Ha Do Nguyen1, Christina Lubahn1, Thomas Leeuw2, Timo Gaber3 and Frank Buttgereit3, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, 3Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
  • Abstract Number: 1114 • ACR Convergence 2022

    Computational Drug Repositioning and 3D Skin Models Identify EGFR and PI3K Inhibitors as Anti-fibrotic Targets for Systemic Sclerosis

    Dillon Popovich1, Noelle Kosarek2, Rezvan Parvizi3, Tamar Abel4, Mengqi Huang5, Monica Espinoza6, Avi Smith7, Sasha Shenk7, Jonathan Garlick7 and Michael Whitfield8, 1Dartmouth College, West Lebanon, NH, 2Dartmouth Geisel School of Medicine, Lebanon, NH, 3Dartmouth, Lebanon, NH, 4Dartmouth College, Lebanon, NH, 5University of Pittsburgh, Pittsburgh, PN, 6Dartmouth College, Hanover, NH, 7Tufts University School of Dental Medicine, Boston, MA, 8Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Genome-wide analyses of gene expression in systemic sclerosis (SSc) skin biopsies have identified differential responses based on the mechanism of action of the therapy.…
  • Abstract Number: 1167 • ACR Convergence 2022

    Towards an Autologous 3D Skin-like Tissue Harboring Patient-Derived Fibroblasts, Keratinocytes, T-cells and Macrophages

    Sasha Shenk1, Jonathan Garlick1, Lev Brown2, Jamie Riesenberg2, Christian Evans2, Julia Jaffe Zweifach2, Andrew Macklin2, Tamar Abel3, Noelle Kosarek4, Mengqi Huang5, Avi Smith1, Tammara Wood3, Gretel Torres6, Patricia pioli6 and Michael Whitfield7, 1Tufts University School of Dental Medicine, Boston, MA, 2Tufts University, Boston, MA, 3Dartmouth College, Hanover, NH, 4Dartmouth Geisel School of Medicine, Lebanon, NH, 5University of Pittsburgh, Pittsburgh, PN, 6Geisel School of Medicine at Dartmouth, Lebanon, NH, 7Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH

    Background/Purpose: Scleroderma (Systemic Sclerosis; SSc) is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction, fibrosis, and inflammation. A lack of human…
  • Abstract Number: 1801 • ACR Convergence 2020

    An Engineered Extracellular Matrix‐rich Decellularized Substrate Based Podocytes Culture System to Study Intracellular Complement Production and Activation

    Abhigyan Satyam1, Maria Tsokos2 and George Tsokos2, 1Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, boston, 2Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: Current technologies do not support long-term cell viability, differentiation and maintenance of podocytes. We developed a biophysical approach, termed macromolecular crowding (MMC), to create…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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