Abstracts tagged "Tissue Engineering"

Abstract Number: 2285 • ACR Convergence 2025
Synovium-on-a-chip – Development of a Humanized Rheumatoid Arthritis Model that Mimics Disease and Patient Biological Heterogeneity
Theresa Wampler Muskardin¹, Ruiqi Chen², Yeji Lee³, Azka Ali³, Andrra Nimoni³, Christele Felix³, Hattie Heiland³, Romy Kallas³, Daniel Ramirez⁴, David Mayman³, Timothy Niewold⁵ and Weiqiang Chen⁶, ¹Hospital for Special Surgery and Weill Cornell Medicine, New York, NY, ²New York University - Tandon School of Engineering, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery, New York, New York, ⁶New York University, Tandon School of Engineering, New York, NY
Background/Purpose: In rheumatoid arthritis (RA), reasons for treatment resistance and alternate strategies that would be more effective in treatment-resistant patients remain unknown. Accurate methodology to…
Abstract Number: 1787 • ACR Convergence 2025
Spatial and Quantitative Semiautomated Image Analysis of Synovial Biopsies Studied Using a Novel High-Plex Immunofluorescence Platform
Estefania Quesada-Masachs¹, Luis Peñaranda Bolaño¹, Aakriti Arora², Jessica Murillo-Saich³, Edward Lo⁴, Tad George⁴, Daniel Tanoeihusada⁴, Sara McArdle⁵ and Monica Guma⁶, ¹University of Miami, Miami, FL, ²University of Miami / Jackson Memorial Hospital, Miami, FL, ³University of California, San Diego, San Diego, CA, ⁴RareCyte, Seattle, WA, ⁵La Jolla Institute for Immunology, La Jolla, CA, ⁶University of California San Diego, San Diego, CA
Background/Purpose: Although not part of the formal ACR criteria for RA, PsA, or OA, synovial pathology can be a helpful tool in clinical practice. Histopathologic…
Abstract Number: 1319 • ACR Convergence 2025
The Association of Rheumatoid Arthritis in Patients with Vitiligo: Systematic Review and Meta-Analysis
Nattanicha Chaisrimaneepan¹, thunyaporn Khoruamklang², Pitchaporn Yingchoncharoen³, Tulaton Sodsri⁴ and Miriam Paz³, ¹Texas Tech University Health Sciences Center, Lubbock, TX, ²²Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, bangkok, Thailand, ³Texas Tech University Health Sciences Center, Lubbock, ⁴Department of Medicine, Texas Tech University Health Sciences Center, Bangkok, Thailand
Background/Purpose: Vitiligo is associated with many autoimmune diseases, but its association with rheumatic disease has not been well-defined. Therefore, we conducted a systematic review and…
Abstract Number: 0016 • ACR Convergence 2024
Establishment of a Human 3D In-Vitro Lymphoid Model to Evaluate Germinal Center Biology
Lichchavi Rajasinghe¹, Govinda Rocky Thomas,², Jee Ho Lee¹, Gary Sims¹ and Tatiana Ort¹, ¹Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, ²AstraZeneca Pharmaceuticals, Gaithersburg, MD
Background/Purpose: Germinal centers (GC) are specialized lymphoid structures found within the B cell follicles of secondary lymphoid tissue formed following infection or immunization. They are…
Abstract Number: 1751 • ACR Convergence 2024
Precision Targeting of Autoreactive 9G4 B Cells in Systemic Lupus Erythematosus Using Engineered Chimeric Antigen Receptor (CAR)- and Chimeric T Cell Receptor (cTCR)-T Cells
Jin Liu¹, Brian Mog¹, Yuanxuan Xia¹, Elana Shaw¹, Alexander Pearlman¹, Dylan Ferris¹, Kyle J. Kaeo¹, Colin Gliech¹, Tolulope Awosika¹, Brock Moritz¹, Tushar Nichakawade¹, Yang Li¹, Stephanie Glavaris¹, Sarah DiNapoli¹, Nikita Marcou¹, Taha Ahmedna¹, Victoria Duarte Alvarado¹, Denis Wirtz¹, Regina Bugrovsky², Scott A. Jenks², Iñaki Sanz³, Daniel Goldman⁴, Michelle Petri⁴, Chetan Bettegowda¹, Suman Paul¹, Kenneth W. Kinzler¹, Shibin Zhou¹, Felipe Andrade⁵, Bert Vogelstein¹ and Maximilian F. Konig¹, ¹The Johns Hopkins University School of Medicine, Baltimore, MD, ²Emory University School of Medicine, Atlanta, GA, ³Emory University School of Medicine, Atlanta, ⁴Johns Hopkins University School of Medicine, Timonium, MD, ⁵The Johns Hopkins University School of Medicine, Timonium, MD
Background/Purpose: The autoreactive B cell compartment in systemic lupus erythematosus (SLE) is characterized by expansion of B cells expressing immunoglobulin heavy variable gene 4-34 (IGHV4-34)…
Abstract Number: 2300 • ACR Convergence 2024
Activation of Tissue-Resident T Cells in Sjögren’s Disease with Human Salivary Organoids
Brandon Law¹, Rahmatullah Rahmati² and Andrew Luster³, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts Eye & Ear, Boston, MA, ³Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Sjögren's disease (SjD) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, particularly the salivary glands. These focal lymphocytic infiltrates are…
Abstract Number: 1769 • ACR Convergence 2023
TNF-Stimulated Production of IL-15 by Fibroblast-Like Synoviocytes Mediates Human Resident Memory T Cells Development in Synovial Organoid Model
Margaret Chang¹, Maryrose Hahn², Madison Mangin¹, Brian Wauford¹, Rachel Blaustein³, Lauren Henderson¹, Kevin Wei⁴ and Peter Nigrovic¹, ¹Boston Children's Hospital, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) are chronic autoimmune diseases that tend to flare repeatedly in the same joints, displaying joint-specific memory.…
Abstract Number: 2181 • ACR Convergence 2023
Secretagogue Effect of PDE4 Inhibitor Apremilast on Human Salivary Gland Organoids Obtained from Primary Sjögren’s Syndrome Patients
Valeria Manfrè¹, Salvatore Parisi², Isabella Caligiuri², Ombretta Repetto³, Alen Zabotti¹, Enrico Pegolo⁴, Cinzia Fabro¹, Salvatore De Vita¹, Vincenzo Canzonieri², Carla Di Loreto⁴, Flavio Rizzolio² and Luca Quartuccio¹, ¹Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, ²Pathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ³Facility of Bio-Proteomics, Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy, ⁴Institute of Pathology, Azienda Sanitaria Universitaria Friuli Centrale c/o Università degli studi di Udine, Udine, Italy
Background/Purpose: In primary Sjögren's syndrome (pSS), salivary epithelial cells show an active role in the initiation and reiteration of the immunomediated damage. Epithelial saliva production…
Abstract Number: 2184 • ACR Convergence 2023
Development of Salivary Gland Organoids to Study Sjögren Syndrome
Loïc Meudec¹, Negaar Goudarzi², Juliette Pascaud³, Fanny Jaulin², Xavier Mariette⁴ and Gaetane Nocturne⁵, ¹CHU Kremlin-Bicêtre, Rheumatology, Le Kremlin-Bicêtre, France, ²INSERM UMR 981, Institut Gustave Roussy, Villejuif, France, Villejuif, France, ³Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, FHU CARE, Université Paris-Saclay, Le Kremlin-Bicêtre, France, ⁴Université Paris-Saclay, Le Kremlin-Bicêtre, France, ⁵APHP, Le Kremlin-Bicêtre, France
Background/Purpose: Sjögren disease (Sjo) is an autoimmune disease characterized by the infiltration of exocrine glands by immune cells, especially salivary glands (SG). SG epithelial cells…
Abstract Number: 020 • 2023 Pediatric Rheumatology Symposium
Generation of Human Resident Memory T Cells in 3D Synovial Organoid Model
Margaret Chang¹, Maryrose Hahn¹, Brian Wauford¹, Rachel Blaustein², Kevin Wei² and Peter Nigrovic¹, ¹Boston Children's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Most rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) patients experience episodic arthritis flares and require life-long medications to control their disease. We observed…
Abstract Number: 023 • 2023 Pediatric Rheumatology Symposium
Effect of Type 1 Interferons and JAK Inhibitors on Gene Expression in Bioengineered Pediatric Skeletal Muscle
Lauren Covert¹, Joseph Prinz², Hailee Patel³, Jeffrey Dvergsten⁴ and George Truskey³, ¹Duke University, Durham, NC, ²Duke University School of Medicine, Department of Biostatistics and Bioinformatics, Durham, NC, ³Duke University, Department of Biomedical Engineering, Durham, NC, ⁴Duke University Hospital, Durham, NC
Background/Purpose: Genetic studies of new-onset juvenile dermatomyositis (JDM) exhibit elevation of Type 1 interferons (IFN 1) IFNα and IFNβ in blood, skin, and muscle. To…
Abstract Number: 1173 • ACR Convergence 2022
Single-cell Multi-omic Analysis of a 3D Skin-Like Tissue Model Provides Insights into Molecular and Cellular Drivers of Systemic Sclerosis
Tamar Abel¹, Noelle Kosarek², Rezvan Parvizi³, Helen Jarnagin¹, Mengqi Huang⁴, Avi Smith⁵, Michael Mariani¹, Dillon Popovich⁶, Heetaek Yang⁷, Tammara Wood⁸, Jonathan Garlick⁹, Patricia Pioli⁷ and Michael Whitfield¹⁰, ¹Dartmouth College, Lebanon, NH, ²Dartmouth Geisel School of Medicine, Lebanon, NH, ³Dartmouth, Lebanon, NH, ⁴University of Pittsburgh, Pittsburgh, PN, ⁵Tufts University, Boston, MA, ⁶Dartmouth College, West Lebanon, NH, ⁷Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁸Dartmouth College, Hanover, NH, ⁹Tufts University School of Dental Medicine, Boston, MA, ¹⁰Geisel School of Medicine, Lebanon, NH
Background/Purpose: Systemic Sclerosis (SSc) currently lacks reliable in vitro models of skin fibrosis constructed from all human cells. We have developed a skin-like tissue model of systemic…
Abstract Number: 1677 • ACR Convergence 2022
Chimeric Autoantigen-T Cell Receptor (CATCR)-T Cell Therapies to Selectively Target Autoreactive B Cells
Brian J. Mog¹, Elana R. Shaw¹, Michael S. Hwang¹, Alexander H. Pearlman¹, Sarah R. DiNapoli¹, Suman Paul¹, Chetan Bettegowda¹, Nickolas Papadopoulos¹, Sandra B. Gabelli¹, Michelle Petri², Antony Rosen¹, Shibin Zhou¹, Kenneth W. Kinzler¹, Bert Vogelstein¹ and Maximilian F. Konig¹, ¹The Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD
Background/Purpose: Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of cancer and can be curative. CD19-targeted CAR-T cells hold promise for the treatment…
Abstract Number: 0030 • ACR Convergence 2022
Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease
Alexandra Damerau¹, Duc Ha Do Nguyen¹, Christina Lubahn¹, Thomas Leeuw², Timo Gaber³ and Frank Buttgereit³, ¹Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, ³Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany
Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
Abstract Number: 1114 • ACR Convergence 2022
Computational Drug Repositioning and 3D Skin Models Identify EGFR and PI3K Inhibitors as Anti-fibrotic Targets for Systemic Sclerosis
Dillon Popovich¹, Noelle Kosarek², Rezvan Parvizi³, Tamar Abel⁴, Mengqi Huang⁵, Monica Espinoza⁶, Avi Smith⁷, Sasha Shenk⁷, Jonathan Garlick⁷ and Michael Whitfield⁸, ¹Dartmouth College, West Lebanon, NH, ²Dartmouth Geisel School of Medicine, Lebanon, NH, ³Dartmouth, Lebanon, NH, ⁴Dartmouth College, Lebanon, NH, ⁵University of Pittsburgh, Pittsburgh, PN, ⁶Dartmouth College, Hanover, NH, ⁷Tufts University School of Dental Medicine, Boston, MA, ⁸Geisel School of Medicine, Lebanon, NH
Background/Purpose: Genome-wide analyses of gene expression in systemic sclerosis (SSc) skin biopsies have identified differential responses based on the mechanism of action of the therapy.…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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