Abstracts tagged "therapeutic targeting and toll-like receptors"

Abstract Number: 2979 • ACR/ARHP Annual Meeting 2014
Nucleic Acid Sensing Receptors TLR7, RIG-I and MDA5 Collaborate in Driving the Systemic IFN Signature and Amplify the Pathogenic Loop: Potential New Targets for Therapy in Primary Sjogrens Syndrome
Naomi I Maria¹, Cornelia G. van Helden-Meeuwsen¹, Eline C. Steenwijk¹, Arne S. IJpma², Wouter Beumer¹, Zana Brkic¹, Virgil A. Dalm¹, Paul L. van Daele¹, P. Martin van Hagen¹, Peter J. van der Spek², Hemmo A. Drexhage¹ and Marjan A. Versnel¹, ¹Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Erasmus Medical Center, Bioinformatics, Rotterdam, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by autoantibodies targeting RNA-associated antigens, anti-SSA/SSB. The IFN-signature is present in over half of…