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Abstracts tagged "Takayasu.s arteritis"

  • Abstract Number: 0179 • ACR Convergence 2022

    Discordant Monozygotic Twins with Juvenile Dermatomyositis: Genetic and Clinical Studies

    Lauren Pachman1, Gabrielle Morgan2, Wilfredo Marin3, Sabah Kadri3, Kai Lee Yap3 and Amer Khojah4, 1Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Ann & Robert H. Lurie Children's Hospital, Chicago, IL, 4Umm Al-Qura University, Makkah, Saudi Arabia

    Background/Purpose: Juvenile Dermatomyositis (JDM) is a rare pediatric autoimmune disease characterized by proximal weakness and skin rash. Although the exact mechanism of JDM is not…
  • Abstract Number: 0465 • ACR Convergence 2022

    Tocilizumab in Large-Vessel Giant Cell Arteritis and Takayasu Arteritis: Multicentric Observational Comparative Study

    Diana Prieto-Peña1, Javier Loricera2, Santos Castañeda3, Clara Moriano4, Pilar Bernabeu5, Paloma Vela-Casampere6, F. Javier Narváez7, Vicente Aldasoro8, Olga Maíz9, Jesús Carlos Fernández-López10, Mercedes Freire10, Rafael Melero11, Juan Ignacio Villa12, Beatriz Gonzalez-Alvarez13, Roser Solans-Laqué14, José Luis Callejas15, Carlos Fernandez-Diaz16, Salvador Garcia-Morillo17, Mauricio Minguez18, Cristina Fernández-Carballido19, Esteban Rubio20, Eugenio De Miguel21, Julio Sánchez-Martín22, Esther Fernandez23, Sheila Melchor24, Eva Salgado-Pérez25, Beatriz Bravo26, Susana Romero Yuste27, Eva Galíndez-Agirregoikoa28, francisca Sivera29, Ivan Ferraz Amaro30, Cristina Hidalgo31, Carlos Romero Gomez32, Carles Galisteo33, Patricia Moya Alvarado34, Noelia Alvarez-Rivas35, Javier Mendizabal36, Juan Carlos Nieto González37, Juan Ramón de Dios38, Jose Luis Andreu39, Nagore Fernandez-Llanio40, Eztizen Labrador41, Enrique Raya Álvarez42, Arantxa Conesa43, Francisco Ortiz-Sanjuan44, Sara Manrique Arija32, Iñigo Rua-Figueroa45, A. García-valle46, Miguel Ángel González-Gay47 and Ricardo Blanco2, 1Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 4Complejo Asistencial Universitario de León, León, Spain, 5Hospital General de Alicante, Alicante, Spain, 6Hospital General Universitario Alicante, Alicante, Spain, 7Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, 8Hospital Universitario de Navarra, Pamplona, Spain, 9Hospital Univesitario de Donostia, Donostia, Spain, 10Complejo H. Universitario de A Coruña, A Coruña, Spain, 11Complexo Hospitalario Universitario de Vigo, Vigo, Spain, 12Hospital Sierrallana, Torrelavega, Spain, 13Hospital Nuestra Señora de la Candelaria, Tenerife, Spain, 14Hospital Vall d’Hebron, Barcelona, Spain, 15Hospital San Cecilio, Granada, Spain, 16H, Murcia, Spain, 17Hospital Virgen del Rocío, Sevilla, Spain, 18San Juan de Alicante, Alicante, Spain, 19Agencia Valenciana de Salud, Alicante, Spain, 20HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO, SEVILLE, Spain, 21Hospital Universitario La Paz, Madrid, Spain, 22Hospital Universitario Marqués de Valdecilla, Santander, Spain, 23Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, 24Hospital Universitario 12 de Octubre, Madrid, Spain, 25Complejo Hospitalario Universitario de Ourense, Santiago de Composte, Spain, 26Hospital Virgen de las Nieves, Madrid, Spain, 27Complexo Hospitalario Universitario, Pontevedra, Spain, 28Basurto University Hospital, Bilbao, Spain, 29Hospital Universitario de Elda, Alicante, Spain, 30Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 31Hospital Universitario Salamanca, Salamanca, Spain, 32Hospital Regional Universitario Málaga, Málaga, Spain, 33Hospital Parc Tauli,, Sabadel, Spain, 34Hospital Parc Tauli, Barcelona, Spain, 35Hospital San Agustin, Aviles, Spain, 36Complejo Hospitalario de Navarra,, Pamplona, Spain, 37Hospital General Universitario Gregorio Marañón, Madrid, Spain, 38Hospital de Araba, Araba, Spain, 39Hospital Puerta de Hierro, Madrid, Spain, 40Hospital Arnau de Vilanova,, València, Spain, 41Hospital San Pedro, Logroño, Spain, 42Hospital Universitario San Cecilio, Granada, Spain, 43Hospital Universitario de Castellón, València, Spain, 44Hospital Universitario de La Fe, València, Spain, 45Hospital Doctor Negrín, Gran Canaria, Spain, 46Completo Asistencial Palencia, Palencia, Spain, 47Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Tocilizumab (TCZ) has shown to be effective for large vessel vasculitis including giant cell arteritis (GCA) and Takayasu arteritis (TAK). However, LVV-GCA and TAK…
  • Abstract Number: 0491 • ACR Convergence 2022

    Markers of Neutrophil Activation in Patients with ANCA-associated Vasculitis and Large-vessel Vasculitis

    Despina Michailidou1, Bhargavi Duvvuri1, Runa Kuley1, David Cuthbertson2, Peter Grayson3, Nader Khalidi4, Curry Koening5, Carol Langford6, Carol McAlear7, Larry Moreland8, Christian Pagnoux9, Philip Seo10, Ulrich Specks11, Antoine Sreih7, Kenneth J. Warrington11, Tomas Mustelin1, Paul Monach12, Peter Merkel13 and Christian Lood1, 1Division of Rheumatology, University of Washington, Seattle, WA, 2University of South Florida, Tampa, FL, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4Division of Rheumatology, Mc Master University, Ontario, Canada, Ontario, Canada, 5Division of Rheumatology, University of Utah, Salt Lake City, UT, USA, Salt Lake City, UT, 6Cleveland Clinic, Cleveland, OH, 7Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 8University of Colorado, Denver, CO, 9Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 10Johns Hopkins University, Baltimore, MD, 11Mayo Clinic, Rochester, MN, 12VA Boston Healthcare System, Boston, MA, 13University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Neutrophils contribute to the pathogenesis of many autoimmune diseases. The purpose of the study was to assess two markers of neutrophil activation, calprotectin and…
  • Abstract Number: 1202 • ACR Convergence 2022

    Clinical Profile and Trend of Vasculitis in Patients with Acute Coronary Syndrome – Insight from National Database 2010 to 2019

    Palak Shah1, Ana Arevalo2, Rasha Alaameri3, Brinda Basida4, Urja Nagadia5, Sanket Basida5, shobhana Chaudhari6 and Monil Majmundar7, 1Metropolitan Hospital Center, New York Medical College, New York, NY, 2University of Chicago, Chicago, IL, 3New York Medical College/ Metropolitan Program, New York, NY, 4DMC/Sinai Grace Hospital, Detroit, MI, 5University of Missouri, Columbia, MO, 6NYC Health and Hospital/Metropolitan Hospital, New York, NY, 7University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: Vasculitides are characterized by inflammation of vessel walls with reactive damage to mural structures leading to compromise of the lumen. Vasculitides also accelerate atherosclerosis…
  • Abstract Number: 1550 • ACR Convergence 2022

    Involvement of Iliofemoral Arteries in PET/CT Are Associated with Atherosclerotic Risk Factors in Takayasu’s Arteritis

    SEMA KAYMAZ-TAHRA1, Salih Ozguven2, Nuh Filizoglu2, Ali Ugur Unal3, Fatma Alibaz-Oner4, Tunc Ones2, Tanju Yusuf Erdil2 and Haner Direskeneli5, 1Sancaktepe Prof Dr Ilhan Varank Training and Research Hospital, Rheumatology, Istanbul, Turkey, 2Marmara University School of Medicine, Department of Nuclear Medicine, Istanbul, Turkey, 3Marmara University School of Medicine, Rheumatology, Istanbul, Turkey, 4Marmara University, Rheumatology, Istanbul, Turkey, 5Marmara University, Rheumatology, Istanbul, Istanbul, Turkey

    Background/Purpose: Iliofemoral artery disease, which is commonly observed in severe atherosclerosis, may also be present in Takayasu's arteritis (TAK). In this study we aimed to…
  • Abstract Number: 1551 • ACR Convergence 2022

    The Utility of Imaging Studies (MRA and CTA) in Long-Term Monitoring for Patients with Takayasu Arteritis

    Saja Almaaitah1, Chao Zhang2 and alexandra villa forte1, 1Cleveland Clinic Foundation, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH

    Background/Purpose: Takayasu Arteritis (TA) is a complex large vessel vasculitis that leads to arterial stenosis, occlusion and aneurysmal formation. Assessment of disease activity is a…
  • Abstract Number: 1552 • ACR Convergence 2022

    Rare Variant Analysis of Aortopathy Genes in Takayasu’s Arteritis

    Hugh Alessi1, Yiming Luo1, Kaitlin Quinn2 and Peter Grayson3, 1NIH, Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: A set of genes has been associated with aortopathies, which are defined as non-inflammatory diseases where the integrity of large arteries is compromised leading…
  • Abstract Number: 1553 • ACR Convergence 2022

    Effectiveness and Safety of Adalimumab versus Leflunomide in Patients with Takayasu Arteritis – a Retrospective Cohort Study

    Faustino Peron Filho1, Andressa de Souza Moreira2, Anna Larissa Janes2 and Alexandre Wagner de Souza2, 1UNIFESP-EPM, Mogi das Cruzes, São Paulo, Brazil, 2UNIFESP-EPM, São Paulo, Brazil

    Background/Purpose: Therapy for Takayasu arteritis (TAK) is based on the combination of high-dose glucocorticoids and immunosuppressive and/or biologic agents. Patients presenting severe disease manifestations are…
  • Abstract Number: 1554 • ACR Convergence 2022

    Serum Biomarkers in Association with Clinical and Vascular Disease Activity in Takayasu’s Arteritis

    Cameron Rankin1, Peter Grayson2, Bates Gribbons3, Kaitlin Quinn4, Christopher Redmond5 and Wanxia Tsai1, 1NIAMS/NIH, Bethesda, MD, 2National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 3McGovern Medical School, Colleyville, TX, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, 5National Institutes of Health, Rockville, MD

    Background/Purpose: 18FDG-PET imaging can be used to directly assess vascular inflammation; however, limited access to this technology has restricted widespread adoption of this modality in…
  • Abstract Number: 1573 • ACR Convergence 2022

    Von – Willebrand Factor, a Possible Marker for Disease Activity in Vasculitis

    Jomana mazareeb1, shiri keret1, Abid Awisat1, Itzhak Rosner2, Michel Rozenbaum3, Lisa Kaly1, Gleb Slobodin1 and Doron Rimar1, 1Bnai Zion Medical Center, Haifa, Israel, 2Bnai Zion Medical Center/Technion, Haifa, Israel, 3Bnei Zion Medical Center, Hertzeliya, Israel

    Background/Purpose: Vasculitis is an inflammation of blood vessels. While in many cases markers of inflammation as c- reactive protein (CRP) or erythrocytes sedimentation rate (ESR)…
  • Abstract Number: 1574 • ACR Convergence 2022

    Vasculitides as Medication-Associated Adverse Events Based on a National Database Reporting System

    Alicia Rodriguez-Pla, Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Vasculitides have been reported as adverse events (AEs) related to a wide variety of medications. We aimed to analyze the vasculitides reported to a…
  • Abstract Number: 2227 • ACR Convergence 2022

    Active Takayasu Arteritis Is Associated with Plasma and Cellular Measures of Endothelial Dysfunction

    Marta Peverelli1, Andrew Porter1, Kerri Malone2, Allan Kiprianos1, Tom McKinnon1, Charis Pericleous1, Robert Maughan1 and Justin Mason1, 1Imperial College London, London, United Kingdom, 2European BioInformatics Institute, Hinxton, United Kingdom

    Background/Purpose: The accurate assessment of disease activity and progression is a major challenge in Takayasu Arteritis (TA). An improved understanding of disease pathogenesis is required…
  • Abstract Number: 2228 • ACR Convergence 2022

    Development of the Takayasu’s Arteritis Integrated Disease Activity Index

    Chiara Marvisi1, Ertugrul Cagri Bolek2, Mark Ahlman3, Hugh Alessi4, Christopher Redmond5, Peter Merkel6, Carlo Salvarani7, Kaitlin Quinn8 and Peter Grayson9, 1Università di Modena e Reggio Emilia and National Institute of Arthritis & Musculoskeletal & Skin Diseases, National Institutes of Health, Bethesda, MD, 2Vasculitis Translational Research Program, NIAMS, NIH, US, Lanham MD, MD, 3National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, Bethesda, MD, 4National Institutes of Health, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 6University of Pennsylvania, Philadelphia, PA, 7Azienda USL -IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Reggio Emilia, Italy, 8National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, 9National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Disease activity indices that accurately assess inflammation in Takayasu's arteritis (TAK) are needed. While clinical assessment is often considered the gold standard, determining if…
  • Abstract Number: 2229 • ACR Convergence 2022

    Ultrasound Localization Microscopy as a New Tool for Takayasu’s Arteritis Activity Assessment, a Deep Insight Within Carotid Wall Inflammation

    Guillaume Goudot1, Anatole Jimenez2, Nassim Mohamedi3, jonas Sitruk3, Lina Khider1, Hélène Mortelette3, Clément Papadacci2, Fabien Hyafil4, Mickaël Tanter2, Emmanuel Messas1, Mathieu Pernot2 and Tristan Mirault1, 1Vascular medicine department, Georges Pompidou European hospital, APHP, Université Paris Cité, INSERM U970 PARCC, Paris, Ile-de-France, France, 2Physics for Medicine Paris, INSERM U1273, ESPCI Paris, CNRS FRE 2031, PSL Research University, Paris, France, 3Vascular medicine department, Georges Pompidou European hospital, APHP, Université Paris Cité, Paris, Ile-de-France, France, 4Nuclear medicine department, Georges Pompidou European hospital, APHP, Universite Paris Cite, INSERM U970 PARCC, Paris, Ile-de-France, France

    Background/Purpose: Use of sulphur hexafluoride microbubbles (MB) with ultrasound allow to assess arterial wall vascularization through signal enhancement. The use of ultrafast imaging with MB…
  • Abstract Number: 0151 • ACR Convergence 2021

    Usefulness of Ultrasound and (FDG) PET/CT to Detect Cranial and Extracranial Artery Involvement in Patients with Suspected Large Vessel Vasculitis

    Juan Molina1, Isabel Castrejón2, Javier Rivera2, Julia Martínez Barrio2, Juan Carlos Nieto2, Katerine López2, Fernando Montero2, Laura Trives Folguera2, Carlos González3 and Jose Maria Alvaro-Gracia2, 1Hospital General Universitario Gregorio Maran, Madrid, Spain, 2Hospital General Universitario Gregorio Marañón, Madrid, Spain, 3CEIMI, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose: Ultrasound (US) is recommended as the first imaging modality to assess patients presenting with predominantly cranial symptoms of giant cell arteritis (GCA). However, its…
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