Abstracts tagged "T-Regulatory Cells and systemic lupus erythematosus (SLE)"

Abstract Number: 150 • ACR/ARHP Annual Meeting 2018
PD-1 Signaling Interferes with OX40L to Alter the Suppressive Function and Proliferation of CD4+ Regulatory T Cells in Lupus Mice
Maida Wong¹ and Bevra H Hahn², ¹Division of Rheumatology, Tibor Rubin Veterans Affairs Medical Center Long Beach, Long Beach, CA, ²Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: In systemic lupus erythematosus (SLE), the dysregulated production of autoantibodies is a consequence of disrupted T cell homeostasis. Programmed death-1 (PD-1), a negative regulator…
Abstract Number: 2075 • ACR/ARHP Annual Meeting 2015
A Unique Naturally-Occurring Regulatory T Cell Subset Associated with Disease Activity in Patients with Systemic Lupus Erythematosus
Tetsuya Nishimoto¹, Yuka Okazaki², Hironari Hanaoka¹, Tsutomu Takeuchi³ and Masataka Kuwana², ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Foxp3 is a lineage-specifying transcription factor for CD4+ regulatory T cells (Tregs), but recent studies have shown plasticity and heterogeneity within CD4+Foxp3+ cells, which…