Abstracts tagged "T-Regulatory Cells and rheumatoid arthritis (RA)"

Abstract Number: 2423 • 2017 ACR/ARHP Annual Meeting
Patients with Active Rheumatoid Arthritis but Normal Levels of Acute Phase Proteins Have Altered Regulatory T Cell Function and Rapidly Progress to Biological Therapies
Claire Bradford¹, Shashank Ramakrishnan¹, Andrew Cole², Coziana Ciurtin³, Elizabeth Jury¹ and Jessica Manson⁴, ¹Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, ²Centre for Rheumatolofy Research, University College London, London, United Kingdom, ³Rheumatology Department, University College London, London, United Kingdom, ⁴University College London Hospitals NHS Trust, London, United Kingdom
Background/Purpose: An atypical subgroup of patients with seropositive rheumatoid arthritis (RA) was identified with active disease (confirmed by Power Doppler ultrasound (PDUS)) but normal levels…
Abstract Number: 1129 • 2016 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Receptor 2 Is Crucial for Regulatory T Cells Activity with Consequences in a Model of Chronic Inflammation and in Anti-TNF Treated Rheumatoid Arthritis
Francois Santinon¹, Maxime Batignes¹, Magali Breckler¹, Roxane Herve¹, Fredéric Caux^1,2, Patrice Decker³, Marie-Christophe Boissier^1,4, Luca Semerano^1,4 and Natacha Bessis⁵, ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, ²Dermatology Dpt, Avicenne teaching Hospital, APHP, bobigny, France, ³UMR 1125, Inserm, Bobigny, France, ⁴Rheumatology Dpt, Avicenne teaching Hospital, APHP, bobigny, France, ⁵INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: CD4+FoxP3+ regulatory T cells (Tregs) are essential for maintaining immune homeostasis, and are functionally defective in rheumatoid arthritis (RA) and other chronic inflammatory diseases.…
Abstract Number: 1642 • 2013 ACR/ARHP Annual Meeting
CD25+CD39+ Regulatory T Cells Are Enriched At The Site Of Inflammation Of Patients With Rheumatoid Arthritis and Impaired In Suppressing IL-17A Secretion
Jessica Herrath¹, Karine Chemin², Inka Albrecht¹, Anca Catrina² and Vivianne Malmström³, ¹Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Department of Medicine, Solna, Unit of Rheumatology, Stockholm, Sweden, ²Department of Medicine, Solna, Unit of Rheumatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Regulatory T cells (Tregs) are important for the maintenance of self-tolerance and are implicated in the origin of autoimmunity. Despite enrichment of Tregs in…

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