Abstracts tagged "T-Regulatory Cells and pediatric rheumatology"

Abstract Number: 927 • 2018 ACR/ARHP Annual Meeting
The Reprogramming of Regulatory T Cells to a Th17 Phenotype in Systemic Juvenile Idiopathic Arthritis
Lauren A. Henderson¹, Kacie Hoyt², Jennifer P. Nguyen³, Pui Lee¹, Deepak Rao⁴, Anna Helena Jonsson⁵, Erin Janssen¹, Fatma Dedeoglu¹, Melissa M. Hazen¹, Mindy S. Lo¹, Esra Meidan¹, Mary Beth Son¹, Robert Sundel¹, Matthew L. Stoll⁶, Chad Nusbaum⁷, James A. Lederer⁸, Talal A. Chatila⁹ and Peter A. Nigrovic^1,5, ¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Boston, MA, ³Department of Surgery, Brigham and Women's Hospital, Boston, MA, ⁴Human Immunology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Broad Technology Labs, Broad Institute, Cambridge, MA, ⁸Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁹Division of Immunology, Boston Children's Hospital, Harvard Medical School, BOSTON, MA
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever and rash at disease onset, which are mediated in part by IL-1β and IL-6. In…

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