Abstracts tagged "T-Regulatory Cells and juvenile arthritis"

Abstract Number: 314 • ACR/ARHP Annual Meeting 2014
Next Generation Sequencing Reveals Restriction of the Treg Cell Repertoire and an Abundance of Shared Synovial Treg Clonotypes in JIA
Lauren A. Henderson¹, Stefano Volpi¹, Francesco Frugoni², Susan Kim¹, Robert P. Sundel¹, Fatma Dedeoglu³, Mindy S. Lo¹, Erin Janssen¹, Melissa M. Hazen¹, Mary Beth Son¹, Ronald Mathieu⁴, David Zurakowski⁵, Robert C. Fuhlbrigge¹, Jolan E. Walter⁶, Yu Nee Lee¹, Peter A. Nigrovic¹ and Luigi D Notarangelo⁷, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Immunology, Boston Children's Hospital, Boston, MA, ³Rheumatology, Boston Children's Hospital, Boston, MA, ⁴Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, ⁵Departments of Anesthesia and Surgery, Boston Children’s Hospital, Boston, MA, ⁶Division of Pediatric Allergy/Immunology, Massachusetts General Hospital for Children, Bpstpm, MA, ⁷Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA
Background/Purpose Regulatory T cell (Treg) dysfunction has been documented in juvenile idiopathic arthritis (JIA), but the basis for this lapse in suppressive capacity is incompletely…