Abstracts tagged "T-Regulatory Cells and auto-immunity"

Abstract Number: 2706 • ACR/ARHP Annual Meeting 2017
T Follicular-Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren’s Syndrome Patients
Elena Pontarini¹, William Murray Brown², Cristina Croia², Elisa Corsiero³, Davide Lucchesi², Elisa Astorri², Nurhan Sutcliffe², Anwar Tappuni², Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹William Harvey Research Institute, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Lymphocytic aggregates in the salivary glands (SG) of Sjögren’s syndrome (SS) can organize in ectopic lymphoid structures (ELS) forming functional germinal centers (GCs), which…
Abstract Number: 1743 • ACR/ARHP Annual Meeting 2014
Antigen-Specificity Regulates Peripheral Homeostasis of Regulatory T Cells
Laura Su¹ and Mark Davis², ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Microbiology, Stanford, Stanford, CA
Background/Purpose One key mechanism of peripheral tolerance involves regulatory T cells (Tregs). Tregs are best known for the expression of the transcription factor Foxp3 that…