Abstracts tagged "T cells and Wegener’s granulomatosis"

Abstract Number: 2319 • 2012 ACR/ARHP Annual Meeting
T Follicular Helper Cell and Regulatory T Cell Frequencies Are Affected by B Cell Depletion in Patients with Granulomatosis with Polyangiitis
Yuan Zhao¹, Jessica Thomas¹, Shirish Sangle², Pamela M.K Lutalo³, Lee Meng Choong⁴, Jennifer R. Tyler¹, Jo Spencer⁵, Timothy Tree⁶ and David P. D'Cruz², ¹Peter Gorer Department of Immunobiology, School of Medicine, King's College London, London, United Kingdom, ²Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ³Louise Coote Lupus Unit, St Thomas Hospital, London, United Kingdom, ⁴Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, ⁵Peter Gorer Department of Immunobiology, King's College London, School of Medicine, London, United Kingdom, ⁶national Institute of Health Research Centre at Guy's and St Thomas' NHS Trust, School of Medicine, King's College London, London, United Kingdom
Background/Purpose: Granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for…

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