Abstracts tagged "T cells and vasculitis"

Abstract Number: 1906 • 2016 ACR/ARHP Annual Meeting
Impact of Environmental Factors and Inflammation on Alterations of the Total Peripheral T-Cell Compartment in Granulomatosis with Polyangiitis
Anja Kerstein¹, Silke Schueler¹, Otávio Cabral-Marques¹, Juliane Fazio², Robert Haesler³, Antje Mueller¹, Silke Pitann¹, Dietrich Kabelitz², Frank Moosig⁴, Sebastian Klapa⁵, Christian Haas⁶, Gabriela Riekemasten¹, Steffen Wolters¹ and Peter Lamprecht¹, ¹Department of Rheumatology, Vasculitis Center UKSH, University of Lübeck, Luebeck, Germany, ²Institute of Immunology, Christian-Albrechts-University of Kiel, Kiel, Germany, ³Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ⁴Rheumatology Center Schleswig-Holstein Mitte, Neumuenster, Germany, ⁵Section Maritime Medicine, Institute of Experimental Medicine, Christian-Albrechs-University of Kiel c/o German Naval Medical Institute, Kronshagen, Germany, ⁶Division of Nephrology, Department of Internal Medicine 1, University of Lübeck, Luebeck, Germany
Background/Purpose: Autoimmune diseases are driven by a combination of predisposing genetic and environmental factors resulting in self-perpetuating chronic inflammation and tissue damage. In granulomatosis with…
Abstract Number: 1951 • 2016 ACR/ARHP Annual Meeting
Phenotypic and Functional Perturbations of Peripheral B and T Lymphocytes in Granulomatosis with Polyangiitis and Microscopic Polyangiitis
Jonathan London^1,2,3, Nicolas Dumoitier¹, Jeremie Dion^1,4, Benjamin Chaigne^1,5, Sebastien Lofek¹, Pascal Cohen^2,3, Claire Le Jeunne³, Nadine Varin-Blank⁶, Loïc Guillevin^3,5, Benjamin Terrier^1,5,7, Luc Mouthon^1,3,5 and the French Vasculitis Study Group, ¹INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, ²Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, ⁴Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁶UFR SMBH, INSERM, UMR978, Bobigny, France, ⁷Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are both anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV), but differ in clinical presentation. Anti-myeloperoxydase (MPO)-ANCA were…

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