Abstracts tagged "T cells and T-Regulatory Cells"

Abstract Number: 122 • 2018 ACR/ARHP Annual Meeting
Metformin Inhibited the Development of Bleomycin-Induced Murine Scleroderma Via Restoring the Balance between Regulatory and Effector T Cells and Suppressing Spleen Germinal Center Formation
Yanlin Wang¹, Zhaojun Liang², Xiangcong Zhao¹, Chong Gao³ and Jing Luo⁴, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²Division of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, Taiyuan, China, ³Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ⁴the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: Scleroderma is a multisystem connective tissue disease characterized by extensive tissue fibrosis and its three prominent cardinal features are vasculopathy, excessive collagen deposition and immunological abnormalities. Metformin (MET)…
Abstract Number: 149 • 2018 ACR/ARHP Annual Meeting
Deep Immune-Profiling of CD4+ T Cells in Behçet’s Disease
Johannes Nowatzky¹, Arshed Al-Obeidi², Yuhe Xia² and Olivier Manches³, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²NYU School of Medicine, New York, NY, ³INSERM, Grenoble, France
Background/Purpose: Functionality and immune-phenotypes of the human CD4+ T-cell compartment in Behçet’s disease (BD) are under-investigated, but several lines of evidence point to its relevance…
Abstract Number: 812 • 2015 ACR/ARHP Annual Meeting
SLAMF3 Mediated Co-Stimulation Promotes Activation of the IL-2/IL-2R/STAT5 Pathway and Regulatory T Cells Differentiation in Human Naïve CD4+ T Cells – Implications for SLE
Denis Comte^1,2, Maria P. Karampetsou¹, Katalin Kis-Toth¹, Nobuya Yoshida¹, Julie Solomon¹, Vasileios C. Kyttaris¹ and George C. Tsokos¹, ¹Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Background/Purpose: SLE is a multisystem autoimmune disease that displays quantitative and qualitative deficiencies of regulatory T cells (Treg), notably because of a compromised IL-2 production.…
Abstract Number: 1948 • 2015 ACR/ARHP Annual Meeting
Early Rheumatoid Arthritis Patients Have Higher Fractions of Circulating Th2 Cells, Th17 Cells and Regulatory T Cells, Similar Fractions of Follicular Helper T Cells, and Lower Fractions of Th17/Th1 Cells and Th1 Cells Compared to Healthy Controls
Jayesh Pandya, Magnus Hallström, Kerstin Andersson, Inger Nordström, Anna-Carin Lundell and Anna Rudin, Dept of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Background/Purpose: A comprehensive analysis of the circulating T cell subtype pattern, including T helper 1 (Th1) cells, Th2 cells, Th17 cells, Th1/Th17 cells, T follicular…

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