Abstract Number: 135 • ACR/ARHP Annual Meeting 2018
High Dimensional Analysis By Mass Cytometry and RNA-Sequencing Reveals Altered Frequency and Exhausted Features of CD4 T and MAIT Cells in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive fibrosis of skin and internal organs, and vascular dysfunction. Association of T and B…Abstract Number: 1121 • ACR/ARHP Annual Meeting 2018
Characterizing the T Cell Receptor Repertoire in Patients with Systemic Sclerosis
Background/Purpose: T cell receptors (TCRs) are a vital component of the adaptive immune system and TCR repertoire diversity is considered a measure of the immune…Abstract Number: 759 • ACR/ARHP Annual Meeting 2017
Multi Dimensional Analysis of the Immunome in Systemic Sclerosis Reveals Functionally Related Abnormalities in MAIT and B Cell Compartments
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive fibrosis of skin and internal organs, and vascular dysfunction. Association of T and B…Abstract Number: 3111 • ACR/ARHP Annual Meeting 2016
Pathogenic T Cell Responses in Systemic Sclerosis Is Shaped By Novel Cytokine Axis in the Microenvironment: A Multidimensional, High Throughput Analysis
Background/Purpose: Pathogenic immune responses can be profoundly shaped by the interplay between the periphery and the microenvironment. In this work we aimed at defining the…Abstract Number: 2905 • ACR/ARHP Annual Meeting 2013
Demethylation of ITGAL (CD11a) regulatory sequences in CD4+T lymphocytes of Systemic Sclerosis
Yaoyao Wang1, Ye Shu2, Qing Wang1, Ming Zhao1, Gongping Liang1, Qianjin Lu1 and Rong Xiao1, 1Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, 2Department of Dermatology, Hunan Children's Hospital, Changsha, China
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease epitomized numerous cellular and humoral immunological abnormalities. The immune system undoubtedly plays a pivotal…Abstract Number: 41 • ACR/ARHP Annual Meeting 2013
Targeting Cereblon With The High Affinity Immunomodulatory Compound CC-220: A Novel Therapeutic Agent For Autoimmunity
Background/Purpose: Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex including CUL4A, DDB1, and ROC-1. CC-220 is a novel immunomodulatory compound currently in…
ACR Meeting Abstracts