Abstracts tagged "T cells and systemic sclerosis"

Abstract Number: 135 • 2018 ACR/ARHP Annual Meeting
High Dimensional Analysis By Mass Cytometry and RNA-Sequencing Reveals Altered Frequency and Exhausted Features of CD4 T and MAIT Cells in Systemic Sclerosis
Bhairav Paleja¹, Andrea Hsiu Ling Low², Pavanish Kumar¹, Suzan Saidin¹, Ahmad Lajam², Camillus Chua³, Liyun Lai¹ and Salvatore Albani⁴, ¹Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore, ³Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴Translational Immunology Institute, Singhealth/Duke-NUS Acedemic Medical Centre, Singapore, Singapore
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive fibrosis of skin and internal organs, and vascular dysfunction. Association of T and B…
Abstract Number: 1121 • 2018 ACR/ARHP Annual Meeting
Characterizing the T Cell Receptor Repertoire in Patients with Systemic Sclerosis
Jennifer Franks¹, Yue Wang², Rajan Bhandari³, Diana M. Toledo⁴, Bhaven K. Mehta², Tammara A. Wood⁵, Noelle Kosarek², Monique Hinchcliff⁶, Chris Bailey-Kellogg⁷, Patricia A. Pioli⁸ and Michael L. Whitfield⁹, ¹Geisel School of Medicine at Dartmouth, Hanover, NH, ²Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ³Geisel School of Medicine at Dartmouth, lebanon, NH, ⁴Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁶Rheumatology, Northwestern University, Chicago, IL, ⁷Computer Science, Dartmouth College, Hanover, NH, ⁸Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁹Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: T cell receptors (TCRs) are a vital component of the adaptive immune system and TCR repertoire diversity is considered a measure of the immune…
Abstract Number: 759 • 2017 ACR/ARHP Annual Meeting
Multi Dimensional Analysis of the Immunome in Systemic Sclerosis Reveals Functionally Related Abnormalities in MAIT and B Cell Compartments
Bhairav Paleja¹, Pavanish Kumar¹, Suzan Saidin¹, Ahmad Lajam², Camillus Chua¹, Liyun Lai¹, Andrea Hsiu Ling Low² and Salvatore Albani¹, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²Singapore General Hospital, Singapore, Singapore
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterised by excessive fibrosis of skin and internal organs, and vascular dysfunction. Association of T and B…
Abstract Number: 3111 • 2016 ACR/ARHP Annual Meeting
Pathogenic T Cell Responses in Systemic Sclerosis Is Shaped By Novel Cytokine Axis in the Microenvironment: A Multidimensional, High Throughput Analysis
Hari Balaji¹, Andrea HL Low², Chieh Hwee Ang³, Raymond Ong Jr.⁴, Juntao Li⁵, Camillus Chua³, Liyun Lai³, Suzan Saidin³ and Salvatore Albani³, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore, Singapore, ²-, Singapore, Singapore, ³SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴Singhealth Translational Immunology and Inflammation Centre (STIIC), Singapore Health Services Pte Ltd, Singapore, Singapore, ⁵Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
Background/Purpose: Pathogenic immune responses can be profoundly shaped by the interplay between the periphery and the microenvironment. In this work we aimed at defining the…
Abstract Number: 2905 • 2013 ACR/ARHP Annual Meeting
Demethylation of ITGAL (CD11a) regulatory sequences in CD4+T lymphocytes of Systemic Sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease epitomized numerous cellular and humoral immunological abnormalities. The immune system undoubtedly plays a pivotal…
Abstract Number: 41 • 2013 ACR/ARHP Annual Meeting
Targeting Cereblon With The High Affinity Immunomodulatory Compound CC-220: A Novel Therapeutic Agent For Autoimmunity
Peter Schafer¹, Emily Rychak², Derek Mendy³, Stacey Parton¹, Lori Capone⁴, Antonia Lopez-Girona², Dorota Cedzik⁵, Jolanta Kosek⁵, Ling-Hua Zhang⁵ and Rajesh Chopra⁵, ¹Department of Translational Development, Celgene Corporation, Summit, NJ, ²Molecular & Medical Science, Celgene Signal Research, San Diego, CA, ³Celgene Signal Research, San Diego, CA, ⁴Celgene Corporation, Summit, NJ, ⁵Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex including CUL4A, DDB1, and ROC-1. CC-220 is a novel immunomodulatory compound currently in…

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