Abstracts tagged "T cells and signal transduction"

Abstract Number: 725 • 2013 ACR/ARHP Annual Meeting
Localization At The Immunological Synapse Of Adaptor Protein Grb2 and PLC Gamma-1 In Non-Stimulated Peripheral Blood T Lymphocytes From Patients With Systemic Lupus Erythematosus Suggests An In Vivo dysregulated Activation State
Nursamaa Abdoel¹, Mireyma Sanchez², Hector Rojas³, Martin Rodriguez⁴ and Ana M. Blasini¹, ¹Sección de Investigación en Inmunoreumatologia, Hospital Universitario de Caracas, Caracas, Venezuela, ²Rheumatology, Hospital Universitario de Caracas, Caracas, Venezuela, ³Instituto de Inmunologia, Escuela de Medicina, Universidad Central de Venezuela, Caracas, Venezuela, ⁴Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Caracas, Venezuela
Background/Purpose: We previously showed an increased metabolic rate of transmembrane adaptor protein LAT in TCR/CD3 stimulated lupus T cells, associated with delocalization of this adaptor…
Abstract Number: 2507 • 2012 ACR/ARHP Annual Meeting
Activated Cullin-Ring Ubiquitin Ligases (CRLs) Dampen T Cell Signaling and Inactivation of Crls Arrests the Progression of Inflammatory Arthritis
Leonard L. Dragone¹, Lisa K. Peterson², Allison Berger³ and Samantha F. Friend², ¹Dept of Pediatrics, National Jewish Health, Denver, CO, ²Pediatrics, National Jewish Health, Denver, CO, ³Department of Millennium Pharmaceuticals, Millennium Pharmaceuticals, Inc, Cambridge, MA
Background/Purpose: The role of Cullin-Ring ubiquitin ligase (CRL) activity in regulating T cell function is largely unexplored. Thus, we sought to determine if cullin neddylation…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].