Abstracts tagged "T cells and rheumatoid arthritis (RA)"

Abstract Number: 1392 • 2019 ACR/ARP Annual Meeting
The Relationship Between Abatacept Exposure and CD86 Receptor Occupancy in Rheumatoid Arthritis Patients Following Subcutaneous Administration and Its Association to Patient Outcomes
Grigor Abelian¹, Sheng Gao ², Yash Gandhi ¹, Blisse Vakkalagadda ¹, Vidya Perera ¹ and Bindu Murthy ¹, ¹Bristol-Myers Squibb, Princeton, ²Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: The purpose of this investigation was to characterize the relationship between systemic exposure of abatacept and measures of target engagement to further support dosing…
Abstract Number: 2426 • 2017 ACR/ARHP Annual Meeting
Altered Frequencies of Circulating Follicullar T Helper Cell Counterparts and Their Subsets but Not of Peripheral Helper T Cells, Are Associated with Increased Circulating Plasmablasts in Seropositive Early RA Patients
Paula Fortea-Gordo¹, Lorena Valdeolivas-De Opazo¹, Laura Nuño², Alejandro Villalba¹, Paloma Sanchez-Mateos³, Amaya Puig-Kröger⁴, Alejandro Balsa¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, ²Rheumatology, La Paz University Hospital, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain, ⁴Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain
Background/Purpose: Follicular T helper (Tfh) cells are typically located in lymphoid organs where they promote B cell differentiation and function. Circulating CD4 T cells expressing…
Abstract Number: 1462 • 2017 ACR/ARHP Annual Meeting
Induction of Immune Tolerance through an Epitope-Specific Vaccine Induces Clinical Amelioration in Patients with Rheumatoid Arthritis
Jin Hui Sherlynn Chan¹, Theodorus van den Broek², Jing Yao Leong¹, Maura Rossetti³, Roberto Spreafico⁴ and Salvatore Albani^1,5, ¹SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²University Medical Center of Utrecht, Utrecht, Netherlands, ³University of California, Los Angeles, Los Angeles, CA, ⁴Synthetic Genomics, La Jolla, CA, ⁵KK Women's and Children's Hospital, Singapore, Singapore
Background/Purpose: The manipulation of immune tolerance using immune checkpoints such as PD-1 is gaining progressive attraction in diseases such cancer where such manipulation would be…
Abstract Number: 2420 • 2017 ACR/ARHP Annual Meeting
Mass Cytometry Analysis of CD4+ T Cells in Patients with Rheumatoid Arthritis
Laura Su¹, Daniel del Alcazar² and Adam Marc², ¹University of Pennsylvania, Philadelphia, PA, ²Medicine, University of Pennsylvania, Philadelphia, PA
Background/Purpose: CD4+ T cells play a key role in the initiation and progression of RA. Past studies have identified impaired function and regulation of several…
Abstract Number: 133 • 2017 Pediatric Rheumatology Symposium
3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-Like T Cells in Rheumatoid Arthritis
Lauren Henderson¹, Deepak Rao², Nikola Teslovich^3,4, Sandra King⁵, Fumitaka Mizoguchi⁶, Sarah Ameri⁶, Allyn Morris⁷, Christopher Elco⁵, Margaret Chang⁸, Anais Levescot⁹, James Lederer¹⁰, Scott Martin¹¹, Barry Simmons¹¹, John Wright¹¹, Michael Brenner², Soumya Raychaudhuri^{12,13,14,15,16}, Robert Fuhlbrigge¹⁷ and Peter Nigrovic^1,18, ¹Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University, Cambridge, MD, ⁴Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, ⁵Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁸Division of Immunology, Boston Children's Hospital, Boston, MA, ⁹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ¹⁰Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹²Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹³Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹⁴Partners Center for Personalized Genetic Medicine, Boston, MA, ¹⁵Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ¹⁶Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, ¹⁷Children's Hospital Colorado, Aurora, CO, ¹⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
Abstract Number: 2924 • 2016 ACR/ARHP Annual Meeting
Terminally Differentiated CD8 T Cell Subset Has Distinct Signiture in RA
Masaru Takeshita¹, Katsuya Suzuki², Yoshiaki Kassai³, Maiko Takiguchi³, Yusuke Nakayama⁴, Keiko Koga³, Rimpei Morita⁵, Takahiro Miyazaki³, Akihiko Yoshimura⁵ and Tsutomu Takeuchi², ¹Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ³Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, ⁴Takeda Pharmaceutical Company Limited, Fujisawa-shi, Japan, ⁵Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Previous reports showed that both CD4 and CD8 T cells were related to the RA disease activity, such as Th17, follicular helper 2, and…
Abstract Number: 994 • 2015 ACR/ARHP Annual Meeting
Th17/Tfh Cell Predict Disease Severity in Rheumatoid Arthritis Patients Receiving TNF Inhibitor Therapy
Deepika Singh¹, Matthew Henkel², Juan (June) Feng³, Jason Lyons⁴, Heather Eng⁵, Larry W. Moreland⁶ and Mandy J. McGeachy², ¹Rheumatology, Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁴School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: In autoimmunity, T follicular helper cells (TfH) are considered drivers of autoantibody production, and T helper 17 (Th17) cells are implicated in tissue-specific inflammation.…
Abstract Number: 1620 • 2015 ACR/ARHP Annual Meeting
DNA Methylation Profiling of Rheumatoid Arthritis Peripheral Blood Identifies Hypermethylation of TRIM69 Promoter Region in CD4+ T Cells Associated with Disease Activity
Amanda Mok¹, Brooke Rhead¹, Calliope Holingue¹, Xiaorong Shao¹, Diana Quach¹, Hong L. Quach¹, Elizabeth Sinclair², Jonathan D. Graf³, Thomas M. Link⁴, Ruby Harrison³, Vladimir Chernitskiy³, Wei Wang⁵, Gary S. Firestein⁶, Lisa F. Barcellos¹ and Lindsey A. Criswell³, ¹Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ²Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ⁴Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁵Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Epigenetic modifications have been previously associated with rheumatoid arthritis (RA [MIM 180300]). This study aimed to determine whether differential DNA methylation in peripheral blood…
Abstract Number: 1933 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient T Cells Recognize Neutrophil Extracellular Traps
Dana E. Orange^1,2,3, Nathalie Blachere¹, Salina Parveen¹, John Fak¹, Mayu Frank¹ and Robert Darnell^3,4,5, ¹The Rockefeller University, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³The New York Genome Center, New York, NY, ⁴Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY, ⁵Howard Hughes Medical Institute, New York, NY
Background/Purpose: The majority of patients with rheumatoid arthritis (RA) harbor anti-citrullinated peptide antibodies, which are correlated with more severe disease. Tetramer based assays have demonstrated…
Abstract Number: 1945 • 2015 ACR/ARHP Annual Meeting
microRNA-30a Promotes the Inflammatory Response of Rheumatoid Arthritis By Regulating Th1 Cell Differentiation
Jing Zhang¹, HUA YE², Jianping Guo¹, Yan Du³, Mengru Liu¹ and Zhanguo Li⁴, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²No.11 XIZHIMENG SOUTH STREET,, Peking University People's Hospital, Beijing, China, ³Department of Rheumatology and Immunology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China, ⁴Peking University People's Hospital, Beijing, China
Background/Purpose: In our previous study, the transcriptome profiles of CD4+T cells from 13 active RA cases and 9 healthy controls were accessed by microarrays. a…
Abstract Number: 3026 • 2015 ACR/ARHP Annual Meeting
The Effects of Lrg on the Differentiation of Naïve T Cells
Hayato Urushima¹, Minoru Fujimoto², Chiharu Iwahashi¹, Tomoharu Ohkawara², Hiromi Honda², Satoshi Serada¹ and Tetsuji Naka², ¹Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, ²Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan
Background/Purpose: Previously, we have identified leucine-rich alpha 2 glycoprotein (LRG) as a disease marker of Rheumatoid arthritis(RA). Although LRG is produced in site of inflammation…
Abstract Number: 1748 • 2014 ACR/ARHP Annual Meeting
CCR6⁺CD4⁺ Cells Are Counterparts of Follicular T-Cells Supporting Autoantibody Production in Rheumatoid Arthritis
Karin ME Andersson¹, Dan Hu², Ron Cialic², Nicola Cavallini³, Vijay K. Kuchroo⁴, Malin Erlandsson¹, Howard Lee Weiner² and Maria Bokarewa⁵, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Department of Neurology, Brigham and Women's Hospital, Boston, MA, ⁵Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose CCR6 has been associated with rheumatoid arthritis (RA) in genome-wide association studies. CCR6 expression characterises Th17 cells recruited to inflamed joints of RA patients.…
Abstract Number: 1471 • 2014 ACR/ARHP Annual Meeting
TNFα Influences the Status of B and T Cells By Acting on BCR and TCR Pathways Via RasGRP1 and RasGRP3 Proteins
Marie-Laure Golinski¹, Martine Hiron², Céline Derambure², Clément Guillou¹, Manuel Fréret², Olivier Boyer³, Olivier Vittecoq⁴ and Thierry Lequerré⁵, ¹Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, ²Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, Rouen, France, ³Immunology, INSERM U905, University of Rouen, Rouen, France, ⁴Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, ⁵1 Rue De Germont, Chu De Rouen, Rouen, France
Background/Purpose Rheumatoid arthritis (RA) is the most common inflammatory arthritis. B and T cells play a key role in the RA pathophysiology. RasGRP is a…
Abstract Number: 1454 • 2014 ACR/ARHP Annual Meeting
Quantitative and Qualitative Tracking of Expanded CD4⁺ T Cell Clones in Rheumatoid Arthritis Patients
Kazuyoshi Ishigaki¹, Hirofumi Shoda², Yuta Kochi³, Tetsurou Yasui⁴, Yuho Kadono⁴, Sakae Tanaka⁴, Keishi Fujio² and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ³Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose The purpose of this study is to elucidate the characteristics of expanded CD4+ T cell clones (ECs) in peripheral blood and synovium of rheumatoid…
Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting
Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis
Zhen Yang¹, Hiroshi Fujii², Eric L. Matteson³, Jorg J. Goronzy¹ and Cornelia M. Weyand⁴, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].