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Abstracts tagged "T cells and monoclonal antibodies"

  • Abstract Number: 123 • ACR/ARP Annual Meeting 2019

    Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope

    Fang Shen1, Karen Duffy 1, Stephane Becart 2, Robert Kuhn 1, Melissa Swiecki 1, Brian Jones 1, Yawei Li 1, Jeffrey Hall 1, Ravi Malaviya 1, Nathan Felix 1, Mimi Zhou 2, Sunil Nagpal 1 and Navin Rao 1, 1Janssen R&D, Spring House, PA, 2Janssen R&D, La Jolla, CA

    Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…
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