Abstracts tagged "T cells and monoclonal antibodies"

Abstract Number: 123 • 2019 ACR/ARP Annual Meeting
Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope
Fang Shen¹, Karen Duffy ¹, Stephane Becart ², Robert Kuhn ¹, Melissa Swiecki ¹, Brian Jones ¹, Yawei Li ¹, Jeffrey Hall ¹, Ravi Malaviya ¹, Nathan Felix ¹, Mimi Zhou ², Sunil Nagpal ¹ and Navin Rao ¹, ¹Janssen R&D, Spring House, PA, ²Janssen R&D, La Jolla, CA
Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…

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Abstracts tagged "T cells and monoclonal antibodies"

Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope