Abstracts tagged "T cells and hematopoietic stem cells"

Abstract Number: 3105 • ACR/ARHP Annual Meeting 2015
The RA Immune System Recreated in Immunodeficient Mice By Thymic Differentiation from RA Patients’ Hematopoietic Stem Cells Exhibits Marked CD4 T Cell Activation and Differentiation
Robert Winchester¹, Chiara Borsotti², Nichole Danzl², Jon Giles³, Joan M. Bathon⁴ and Megan Sykes², ¹Dept of Pediatrics & Medicine, Columbia University, New York, NY, ²Medicine, Columbia University, New York, NY, ³Rheumatology, Columbia University Medical Center, NY, NY, ⁴Medicine, Columbia University, College, New York, NY
Background/Purpose: We recently reported an advance in modeling the human immune system in mice, (Kalscheuer et al. Sci Transl Med 2012) involving maturation of patient…