Abstracts tagged "T cells and epigenetics"

Abstract Number: 182 • ACR/ARHP Annual Meeting 2016
Histone Methylation in γδ T Cells As a Biomarker of Behcet’s Disease Activity
Yoshimi Aizaki^1,2, Yasuto Araki^1,2, Kojiro Sato¹, Kazuhiro Yokota¹ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Behcet’s disease (BD) is a chronic recurrent, multisystem inflammatory disorder. The phenotypic characteristics include oral aphtha, genital ulcers, uveitis and skin lesions. No specific…
Abstract Number: 868 • ACR/ARHP Annual Meeting 2014
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 1874 • ACR/ARHP Annual Meeting 2013
Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals
John Glossop^1,2, Nicola Nixon², Richard Emes³, Kim Haworth¹, Jonathon Packham², Peter Dawes², Anthony Fryer¹, Derek Mattey^1,2 and William Farrell¹, ¹Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, United Kingdom, ²Rheumatology, Haywood Rheumatology Centre, Stoke-on-Trent, United Kingdom, ³School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonnington, United Kingdom
Background/Purpose: Multiple reports now describe changes to the DNA methylome in a variety of autoimmune disorders, such as rheumatoid arthritis. In many cases, these studies…
Abstract Number: 1637 • ACR/ARHP Annual Meeting 2013
IKZF1 Modulates PP2Ac Expression Through An Intronic Binding Site
Kamalpreet Nagpal¹, Katsue S. Watanabe² and George C. Tsokos³, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
IKZF1 modulates PP2Ac expression through an intronic binding siteKamalpreet Nagpal1, Katsue Sunahori2, George C. Tsokos11Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center,…
Abstract Number: 715 • ACR/ARHP Annual Meeting 2013
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression In CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…