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Abstracts tagged "systemic sclerosis and wounds"

  • Abstract Number: 255 • ACR/ARHP Annual Meeting 2017

    Healing Time and Blood Perfusion By Laser Speckle Contrast Analysis in Patients with Systemic Sclerosis and Digital Ulcers

    Simone Barsotti1,2, Anna d'Ascanio1, Valentina Venturini3, Laura Amanzi4, Silvia Bilia5, Marta Mosca1 and Alessandra Della Rossa6, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Department of Medical Biotechnologies, University of Siena, Siena, Italy, 3Pisa University Hospital, Rheumatology unit, Pisa, Italy, 4Pisa University Hospital, Rheumatology Unit, Pisa, Italy, 5Univerisity of Pisa, Rheumatology Unit, Pisa, Italy, 6University of Pisa, Rheumatology Unit, Pisa, Italy

    Background/Purpose: Digital ulcers (DUs) are a major burden in patients with systemic sclerosis (SSc). Laser speckle contrast analysis (LASCA) is a novel technique that can…
  • Abstract Number: 1717 • ACR/ARHP Annual Meeting 2017

    Skin Commensal Bacteria Might Affect Wound Repair in SSc By Preventing Fibroblast Activation and By Provoking Chronic Inflammatory Reaction

    Masaya Yokota1, Janine Schniering1, Oliver Distler2 and Britta Maurer3, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Chronic digital ulcers (DU) due to peripheral microangiopathy are a major complication in systemic sclerosis (SSc). Chronic wounds are often enriched in bacteria without…
  • Abstract Number: 1719 • ACR/ARHP Annual Meeting 2017

    Accelerated Wound Healing in Megakaryocyte/Platelet-Specific Fli1 Knockout Mice Due to the up-Regulated Expression of Interferon-γ

    Megumi Hirabayashi1, Yoshihide Asano2, Takashi Yamashita1, Ryosuke Saigusa1, Shunsuke Miura3, Kouki Nakamura1, Takuya Miyagawa1, Takashi Taniguchi1, Ayumi Yoshizaki1 and Shinichi Sato4, 1Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 2Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 3University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 4Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

    Background/Purpose: Fli1 deficiency, a potential predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in dermal fibroblasts, endothelial cells, keratinocytes, and macrophages. However, it is…
  • Abstract Number: 1853 • ACR/ARHP Annual Meeting 2016

    Klf5+/-;Fli1+/- Mice Recapitulate Protracted Wound Healing and Cardiac and Intestinal Involvement Associated with Systemic Sclerosis

    Kouki Nakamura1, Yoshihide Asano2, Takuya Miyagawa3, Megumi Hirabayashi3, Takashi Yamashita3, Ryosuke Saigusa1, Shunsuke Miura2, Tetsuo Toyama3,4, Takehiro Takahashi1, Yohei Ichimura1, Takashi Taniguchi1, Ayumi Yoshizaki3, Maria Trojanowska4 and Shinichi Sato1, 1Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2University of Tokyo Graduate School of Medicine, Tokyo, Japan, 3Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 4Arthritis Center, Boston University, Arthritis Center, Boston, MA

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis. Although the most recognizable manifestation is skin disease, SSc can…

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