ACR Meeting Abstracts

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Abstracts tagged "systemic sclerosis and vasculogenesis"

  • Abstract Number: 130 • 2018 ACR/ARHP Annual Meeting

    The Role of Cofilin, an Actin Associated Protein, in Activation of Systemic Sclerosis Vascular Smooth Muscle Cells

    Shadia Nada, Bashar Kahaleh and Nezam Altorok, Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by activation of the immune system, vascular dysfunction and tissue fibrosis. Vascular dysfunction in…
  • Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells:  Identification of Epigenetically Affected Key Genes and Pathways

    Shadia Nada1, Ibtissam Gad2, Ali Alqahtani3, Ahmad Assaly2, Sadik Khuder4, Yongqing Wang5, Bashar Kahaleh1 and Nezam Altorok1, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2University of Toledo, Toledo, OH, 3Internal Medicine, University of Toledo, Toledo, OH, 4Department of Medicine, University of Toledo, Toledo, OH, 5Medicine, University of Toledo, Toledo, OH

    Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
  • Abstract Number: 1679 • 2017 ACR/ARHP Annual Meeting

    Different Cut-Offs for Renal Resistive Index Reflect Renal and Other Organ Involvement and Predict Worsening in SSc Patients

    Cosimo Bruni1, Vanessa Maestripieri2, Giulia Tesei3, Marco Chiostri4, Serena Guiducci3, Silvia Bellando-Randone1, Maria Boddi4 and Marco Matucci-Cerinic3, 1Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Firenze, Italy, 2Department of Internal Medicine, Division of Medicine for Care Complexity III, University of Florence, Florence, Italy, 3Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy, 4Department of Heart and Vessels, Division of Cardiology I, University of Florence, Florence, Italy

    Background/Purpose: Renal Resistive Index (RRI), measured by Doppler ultrasound, reflects changes in both renal vascular and tubular-interstitial compartments and systemic vascular compliance related to age…
  • Abstract Number: 1860 • 2016 ACR/ARHP Annual Meeting

    Activating Transcription Factor 3 – a New Linkage Between Vasculopathy and Organ Fibrosis in Systemic Sclerosis

    Thomas Wohlfahrt1, Alina Soare2, Tatjana Mallano2, Morgane Gourlaouen3, Stephen Moss3, Britta Maurer4, Oliver Distler4, Tsonwin Hai5, Georg Schett2, Jörg Distler2 and Andreas Ramming2, 1Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Institute of Ophthalmology, Department of Cell Biology, University College London, London, United Kingdom, 4Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 5Department of Molecular and Cellular Biochemistry, The Ohio State University, Colombus, OH

    Background/Purpose: Since vascular manifestations such as Raynaud’s phenomenon and morphological changes on nailfold capillaroscopy often precede the onset of other clinical manifestations of systemic sclerosis…
  • Abstract Number: 1928 • 2015 ACR/ARHP Annual Meeting

    Isolation and Initial Characterization of Dermal Vascular Smooth Muscle Cells in Systemic Sclerosis

    Shadia Nada1, Farouk Abu Alhana2, Yongqing Wang2, Nezam Altorok3 and Bashar Kahaleh4, 1Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, 2The University of Toledo, Toledo, OH, 3Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, 4Medicine/Rheumatology, The University of Toledo, Toledo, OH

    Background/Purpose: Nearly all patients with Systemic sclerosis (SSc) suffer from vascular dysfunction as illustrated by the uniform presence of Raynaud’s phenomena. The role of vascular…
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