Abstracts tagged "systemic sclerosis and tofacitinib"

Abstract Number: 118 • ACR/ARHP Annual Meeting 2018
Pharmacological Inhibition of JAK/STAT Signaling By Tofacitinib Prevents Experimental Organ Fibrosis: Novel Therapy for Systemic Sclerosis
Swati Bhattacharyya¹, Wenxia Wang², Jun Wei³ and John Varga¹, ¹Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Northwestern University, chicago, IL
Background/Purpose: Synchronous fibrosis in systemic sclerosis (SSc) leads to failure of the skin, lungs and other organs, and has no effective treatments. Myofibroblast activation underlies…