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Abstracts tagged "systemic sclerosis and tissue engineering"

  • Abstract Number: 1903 • ACR/ARHP Annual Meeting 2018

    Molecular Analysis of a Skin Equivalent Tissue Culture Model System of Systemic Sclerosis Using RNA Sequencing, Epigenetic Assays, Histology, and Immunoassays

    Diana M. Toledo1, Mengqi Huang2, Yue Wang2, Bhaven K. Mehta2, Tammara A. Wood3, Avi Smith4, Yolanda Nesbeth5, Irena Ivanovska6, Brock Christensen7, Patricia A. Pioli8, Jonathan Garlick4 and Michael L. Whitfield9, 1Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 3Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 4Tufts University School of Medicine, Boston, MA, 5Celdara Medical, LLC, Lebanon, NH, 6Celdara Medical, LLC, Hanover, NH, 7Geisel School of Medicine at Dartmouth, Hanover, NH, 8Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, 9Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: The molecular mechanisms of systemic sclerosis (SSc) have been difficult to study outside of patient samples. Mouse models often lack key features of the…

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