ACR Meeting Abstracts

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Abstracts tagged "Systemic lupus erythematosus (SLE)"

  • Abstract Number: 0990 • ACR Convergence 2022

    KPG-818, a Novel Cereblon (CRBN) Modulator, in Patients with SLE: Results of a Phase Ib Multiple Ascending Dose Study

    RAMESH C. GUPTA1, Paul Lunseth2, Robert Levin3, Philip Waller4, Amber Khan5, Lester Hernandez5, Kai Wei6, Baisong Liao6, Tao Wang7, Kaiyue Hao7, Yanjiao Yin7 and Yong Guo7, 1Shelby Research LLC, Memphis, TN, 2Clinical Research of West Florida, Tampa, FL, 3Clinical Research of West Florida. Inc., Clearwater, FL, 4Accurate Clinical Research, Houston, TX, 5Accurate Clinical Management, LLC., Houston, TX, 6Kangpu Biopharmaceuticals, Ltd., Shanghai, China, 7Kangpu Biopharmaceuticals, Ltd, Shanghai, China

    Background/Purpose: KPG-818 is a novel CRL4-CRBN E3 ubiquitin ligase modulator that binds to CRBN with high affinity and leads to rapid and effective degradation of…
  • Abstract Number: 1101 • ACR Convergence 2022

    Sex and Racial Differences in Systemic Lupus Erythematosus Among U.S. Adults in the All of Us Research Program

    Rachel Elam1, Deepak Ayyala1, Adria Madera-Acosta1, Stephen Bell1, Anam Qureshi1, Christopher Rice2, Laura Carbone1, Steven Coughlin1 and Hong Shi3, 1Augusta University, Augusta, GA, 2Moses H. Cone Memorial Hospital, Augusta, GA, 3Department of Internal Medicine/Division of Rheumatology, Vascular Biology Center, Augusta, GA

    Background/Purpose: Most persons with systemic lupus erythematosus (SLE) are women, and men with SLE are an understudied demographic. The purpose of this study was to…
  • Abstract Number: 1279 • ACR Convergence 2022

    Development of ACR Longitudinal Digital Quality Measures for Systemic Lupus Erythematosus: A Literature Review and Modified Delphi Consensus Study

    Christie Bartels1, April Jorge2, Candace Feldman3, Claire Barber4, April Barnado5, Bonnie Bermas6, Ali Duarte-Garcia7, Shivani Garg8, Leah Haseley9, Shraddha Jatwani10, Tracy Johansson11, Alex Limanni12, Wendy Rodgers13, Brad Rovin14, Yesenia Santiago-Casas15, Lisa Suter16, Jennifer Ude11, JoAnn Zell17 and Jinoos Yazdany18, 1University of Wisconsin School of Medicine and Public Health, Madison, WI, 2Massachusetts General Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4University of Calgary, Calgary, AB, Canada, 5Vanderbilt University Medical Center, Nashville, TN, 6UT Southwestern, Dallas, TX, 7Mayo Clinic, Rochester, MN, 8University of Madison, School of Medicine and Public Health, Madison, WI, 9University of Washington, Harborview Medical Center, Seattle, WA, 10Albert Einstein Medical Center, Ambler, PA, 11American College of Rheumatology, Atlanta, GA, 12Self, Dallas, TX, 13Lupus Foundation of America, Torrance, CA, 14The Ohio State University, Columbus, OH, 15Integral Rheumatology and Immunology Specialists, Plantation, FL, 16Yale School of Medicine, New Haven, CT, 17University of Colorado Anschutz Medical Campus, Denver, CO, 18UCSF, San Francisco, CA

    Background/Purpose: Significant morbidity and mortality urge efforts to improve quality of care for people with systemic lupus erythematosus (SLE). Yet, none of the 25 American…
  • Abstract Number: 1378 • ACR Convergence 2022

    Childhood-onset Systemic Lupus Erythematosus: Long-term Outcomes in a Large Multi-ethnic Ontario Cohort

    Ha-Seul Jeoung1, Kuan Liu1, Roberta Berard2, Wes Fidler3, Janet Pope4, Johannes Roth5, Carter Thorne6, Earl Silverman7 and Deborah Levy8, 1University of Toronto, Toronto, ON, Canada, 2London Health Sciences Centre, London, ON, Canada, 3St. Joseph's Hospital, Thunder Bay, ON, Canada, 4University of Western Ontario, London, ON, Canada, 5University of Ottawa, Ottawa, Canada, 6Southlake Regional Health Centre, Newmarket, ON, Canada, 7The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: The long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care is not well documented. The present study aims to fill…
  • Abstract Number: 1451 • ACR Convergence 2022

    Delayed Sleep Phase Syndrome Characterizes Circadian Disorder in Patients with Active SLE

    Christina Stankey1, Philip Chu2, Alicia Hinze3, Lily McMorrow1, Alia El-Qunni1, Deepali Sen1, Seth Eisen1, Yo-El Ju1 and Alfred Kim1, 1Washington University School of Medicine, St. Louis, MO, 2Duke University Hospital, Raleigh, NC, 3Mayo Clinic - Rochester, MN, Rochester, MN

    Background/Purpose: Poor sleep quality is a common complaint of patients with SLE. Although chronic sleep disruption is known to drive circadian rhythm disorders, the effects…
  • Abstract Number: 1471 • ACR Convergence 2022

    Trends and Predictors of Hospitalizations Due to Acute Myocardial Infarction in Systemic Lupus Erythematosus Patients

    Izza Bazigh1, Uzair Khan2, Achint Patel3, Aaparna Singh3, Neha Ghalib3, Ghazi Farman4, Salman Muddassir3, Farrukh Zaidi5, Sami Mughni3 and Adam Grunbaum6, 1HCA Florida Oak Hill Hospital, Spring Hill, FL, 2HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Odessa, FL, 3HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Spring Hill, FL, 4Rehman Medical College, Spring Hill, FL, 5HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Port Richey, FL, 6Gulf Coast Rheumatology, Trinity, FL

    Background/Purpose: Cardiovascular events occur more frequently and with earlier onset in patients with Systemic Lupus Erythematosus (SLE) compared with healthy individuals. Several studies have concluded…
  • Abstract Number: 1592 • ACR Convergence 2022

    Serious Infections in SLE- Incidence, Associated Factors, Impact and Trends over Two Decades

    Rudrarpan Chatterjee, Sarit Sekhar Pattanaik, Durga P Misra, Vikas Agarwal, Able Lawrence and Amita Aggarwal, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Infections are a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). We assessed the incidence and risk factors for major infections…
  • Abstract Number: 1697 • ACR Convergence 2022

    Measurements of Specific Activation Through the Lectin -or Classical Pathway of Complement in Patients with SLE

    Anne Troldborg1, Mads Lamm Larsen1, Erik J.M. Toonen2, Lisa Hurler3, Zoltan Prohaszka3, László Cervenak3, Annette Gudmann Hansen4 and Steffen Thiel4, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Hycult Biotech, Arnhem-Nijmegen, Netherlands, 3Semmelweis University, Budapest, Hungary, 4Aarhus University, Aarhus, Denmark

    Background/Purpose: In systemic lupus erythematosus (SLE), the complement system is activated and commonly thought to occur through the classical pathway (CP) [1]. However, our previous…
  • Abstract Number: 1753 • ACR Convergence 2022

    Temporal Trends of SLE Mortality Among Various Ethnic Categories Across the United States: 2001-to 2020 Analysis from WONDER Database

    Ikwinder Preet Kaur1, Harjot Jagdey2, hasan Mirza3, Waqar Mughal4 and Pankaj Bansal5, 1Rutgers/Monmouth Medical Center, Long branch, NJ, 2BronxCare Hospital, Bronx, NY, 3Berkshire Medical Center, Pittsfield, MA, 4DHQ teaching hospital, Gujrat, Pakistan, 5Mayo Clinic, Eau Claire, WI

    Background/Purpose: Racial disparities in SLE have been well described. Blacks are disproportionately affected, and have a higher incidence, disease severity, and mortality compared to Whites,…
  • Abstract Number: 2058 • ACR Convergence 2022

    Evidence on the Construct Validity of the Perceived Deficits Questionnaire Among Adult Patients with Systemic Lupus Erythematosus

    Stefan Perera1, Jiandong Su2, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, Joan Wither1, May Choi6, Simone Appenzeller7, Dorcas Beaton8, Dennisse Bonilla2, Patricia Katz9, Robin Green5, Michelle Barraclough10 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, São Paulo, Brazil, 8Institute for Work & Health, Toronto, ON, Canada, 9UCSF, San Rafael, CA, 10Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is prevalent in SLE and negatively impacts social and occupational engagement. There is a need for a patient-reported outcome measure (PROM)…
  • Abstract Number: 2076 • ACR Convergence 2022

    Unfavorable Outcomes Associated with Current Standard of Care in the Management of Patients with Systemic Lupus Erythematosus

    Zahi Touma1, Sheena Kayaniyil2, Anna Parackal2, Dennisse Bonilla1, Jiandong Su1, Christina Qian3, Sally Miller3, Shelagh Szabo3 and Shelly Chandran2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2AstraZeneca, Mississauga, ON, Canada, 3Broadstreet Health Economics & Outcomes Research, Vancouver, BC, Canada

    Background/Purpose: The effectiveness of current standard of care treatment including corticosteroids (CS) in Systemic Lupus Erythematosus (SLE) is limited and has potential side-effects. Given the…
  • Abstract Number: 2096 • ACR Convergence 2022

    Role of Cell-Bound Complement Fragments as Biomarkers to Determine Disease Activity in Patients with Systemic Lupus Erythematosus

    Marcela Muñoz Urbano1, Diana C. Quintero-González1, Mauricio Rojas2, Joaquín Rodelo1, Alba Luz León Álvarez1, Luis Gonzalez1 and Gloria Vásquez3, 1Universidad de Antioquia, Medellín, Colombia, 2Grupo de Inmunología Celular e Inmunogenética, GICIG, and Unidad de citometría de flujo, Sede de Investigación Universitaria, Universidad de Antioquia, Medellín, Colombia, 3Grupo de Inmunología Celular e Inmunogenética, GICIG and Grupo de Reumatología, Universidad de Antioquía, Medellín, Colombia

    Background/Purpose: The prompt identification of patients with systemic lupus erythematosus (SLE) at risk of or in flare strongly influences the prognosis of the disease. Cell-bound…
  • Abstract Number: 2202 • ACR Convergence 2022

    Association of Visit-based Retention and Receipt of Serologic Testing with Acute Care Use Among Young Adults with Lupus: A Medicare Cohort Study

    Maria Schletzbaum1, Brad C. Astor2, W. Ryan Powell3, Shivani Garg4, Andrea Gilmore-Bykovskyi5, Joseph A. Kramer6, Amy J. Kind7 and Christie Bartels8, 1University of Wisconsin School of Medicine and Public Health, Department of Population Health Sciences, Middleton, WI, 2University of Wisconsin School of Medicine and Public Health, Department of Medicine, Nephrology Division and Department of Population Sciences, Madison, WI, 3University of Wisconsin School of Medicine and Public Health, Center for Health Disparities Research, Thousand Oaks, CA, 4University of Madison, School of Medicine and Public Health, Madison, WI, 5University of Wisconsin School of Medicine and Public Health, Department of Emergency Medicine; and the Center for Health Disparities Research, Madison, WI, 6University of Wisconsin School of Medicine and Public Health, Department of Medicine & Center for Health Disparities Research,, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division & Center for Health Disparities Research, Madison, WI, 8University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: While high quality lupus care is associated with less damage, the impact of care use patterns and care quality on lupus outcomes remains unclear,…
  • Abstract Number: 0016 • ACR Convergence 2022

    Distinct Transcriptomic and Epigenetic Profiles Mediated by Disease Activity in SLE

    Yusho Ishii, James Rose, Kevin Cashman, Sakeenah Hicks, Tsuneo Deguchi, Christopher Scharer, Scott Jenks, Jeremy Boss and Iñaki Sanz, Emory University, Atlanta, GA

    Background/Purpose: SLE is an autoimmune disease heterogenous for symptoms, disease severity and therapeutic response. This heterogeneity makes stratifying patients difficult. B cells from SLE patients…
  • Abstract Number: 0107 • ACR Convergence 2022

    Short-, Intermediate- and Long-Term Renal Outcomes in Hispanics from Puerto Rico with Lupus Nephritis: Induction Therapy with Cyclophosphamide vs. Mycophenolate Mofetil

    Suheiry Márquez, Dahima Cintrón and Luis Vilá, University of Puerto Rico Medical Sciences Campus, San Juan, PR

    Background/Purpose: The American College of Rheumatology (ACR) guidelines for the treatment of class III and class IV lupus nephritis (LN) recommend induction therapy with mycophenolate…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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