Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2102 • ACR Convergence 2022
Does Remission According Definition of Remission in SLE (DORIS) 2021 Match the Treating Rheumatologist Judgment? Analysis at Recruitment of a Prospective Study of 500 SLE Patients from a Spanish Multicenter Cohort
Irene Altabas Gonzalez¹, Coral Mouriño Rodriguez¹, Iñigo Rúa-Figueroa², Francisco Rubiño³, Iñigo Hernandez Rodriguez¹, Raul Menor Almagro⁴, Esther Uriarte Isacelaya⁵, Eva Tomero Muriel⁶, Tarek Carlos Salman-Monte⁷, Irene Carrion Barbera⁸, maria Galindo⁹, Esther Rodriguez Almaraz⁹, Norman Jimenez¹⁰, Luis Ines Sousa¹¹ and Jose M Pego-Reigosa¹², ¹Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ²Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain, ³Hospital Universitario de Jerez de la Frontera, Jerez de la frontera, Spain, ⁴Hospital Jerez de la Frontera, Cádiz, Spain, ⁵Hospital Universitario Donostia, Donostia, Spain, ⁶Hospital Universitario La Princesa, Madrid, Spain, ⁷Hospital del Mar/Parc de Salut Mar-IMIM/UEC-AIS, Barcelona, Spain, ⁸Hospital del Mar, Rheumatology, Barcelona, Spain, ⁹Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰IRIDIS Group, Vigo, Spain, ¹¹Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal, ¹²Hospital Meixoeiro, Vigo, Spain
Background/Purpose: An accurate target in Systemic Lupus Erythematosus (SLE) Treat to Target strategies has been challenging over the past years. Recently, a new definition of…
Abstract Number: 2226 • ACR Convergence 2022
Accelerated Aging Based on Blood DNA Methylation in SLE Participants Compared to Healthy Controls
Joanne Nitithalm¹, Olivia Solomon², Laura Trupin³, Patricia Katz⁴, Jinoos Yazdany⁴, Maria Dall'Era⁵, Lisa F Barcellos², Lindsey Criswell⁶ and Cristina M Lanata⁷, ¹NIH/NHGRI, Bethesda, MD, ²University of California, Berkeley, Berkeley, CA, ³UC San Francisco, San Francisco, CA, ⁴UCSF, San Rafael, CA, ⁵University of California, Division of Rheumatology, San Francisco, CA, ⁶National Human Genome Research Institute, NIH, Bethesda, MD, ⁷NIH/NHGRI, Washington, DC
Background/Purpose: Epigenetic clocks based on DNA methylation in blood have been shown to correlate with biological aging and predict adverse health outcomes, including mortality. Accelerated…
Abstract Number: 0064 • ACR Convergence 2022
Utilization of Preventive Services in a Systemic Lupus Erythematosus Population-Based Cohort: A Lupus Midwest Network Study
Baptiste Chevet¹, Gabriel Figueroa Parra¹, Jeffrey X. Yang¹, Mehmet Hocaoglu¹, Shirley-Ann Osei-Onomah¹, Cassondra Hulshizer¹, Tina Gunderson¹, Divi CORNEC², Cynthia Crowson³ and Ali Duarte-Garcia¹, ¹Mayo Clinic, Rochester, MN, ²CHRU Brest, Brest, France, ³Mayo Clinic, Eyota, MN
Background/Purpose: Systemic lupus erythematosus (SLE) is a disease that can damage multiple organs and, along with certain treatments, increase the risk of developing cancer, cardiovascular…
Abstract Number: 0183 • ACR Convergence 2022
LupusConnect™: A 24/7 Online Lupus Support Community
Leticia Ocana, Ashley Holden and Daria McClamb, Lupus Foundation of America, Washington, DC
Background/Purpose: A Lupus Foundation of America (LFA) National Needs Assessment Survey in 2015 with 3402 lupus patients and caregivers found that the number one need…
Abstract Number: 0331 • ACR Convergence 2022
Anti-dsDNA Antibodies by Multiplex Flow Immunoassay and Critihidia Luciliae Assays in NYU Lupus Registry: Discordance, Association with Nephritis, and Disease Flare Predictive Value
Devyn Zaminski¹, Amit Saxena¹, Peter Izmirly², Jill Buyon² and H Michael Belmont¹, ¹NYU School of Medicine, New York, NY, ²NYU Grossman School of Medicine, New York, NY
Background/Purpose: SLE is characterized by autoantibody production. The most common lupus-specific serology is the anti-dsDNA antibody (anti-DNA). Traditionally, anti-DNA is measured by an enzyme immunoassay…
Abstract Number: 0348 • ACR Convergence 2022
Significant Improvement in Cutaneous Lupus Erythematosus with or Without Systemic Lupus Erythematosus with Belimumab Use – a Systematic Review and Meta-Analysis
Rachel Kneeland¹, Daniel Montes¹, Justin endo¹, Bridget Shields¹, Christie Bartels² and Shivani Garg³, ¹University of Wisconsin, School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³University of Madison, School of Medicine and Public Health, Madison, WI
Background/Purpose: Cutaneous lupus erythematosus (CLE) with or without systemic lupus erythematosus (SLE), can be debilitating and cause significant scarring and psychological distress. Belimumab, a monoclonal…
Abstract Number: 0370 • ACR Convergence 2022
Preliminary Findings from a Randomized Clinical Trial Show a Remotely Delivered Psychological Intervention May Be Beneficial to Youth with Childhood-Onset Lupus
Natoshia Cunningham¹, Samantha Ely¹, ashley Danguecan², Mallet Reid³, Alaina Miller⁴, Mathew Reeves³, Lawrence Ng², Paris Moaf², Sarah Mossad², Tala El Tal⁵, Luana Flores Pereira², Deborah Levy⁶, Linda Hiraki⁷, Jennifer Stinson², Sara Ahola Kohut², khalid abulaban⁸, Elizabeth Kessler⁹, Stacy Allen⁸, Tamar Rubinstein¹⁰, Evin Rothschild¹¹, Natalie Rosenwasser¹², Kabita Nanda¹², Susan Canny¹², Emily Smitherman¹³, Livie Huie¹³, James Birmingham¹⁴, Allison Thompson¹⁵, Janel Thompson¹⁵, Miranda Moyer¹⁵, Angela Chapson Emily Nguyen¹⁵ and Andrea Knight⁵, ¹Michigan State University, Grand Rapids, MI, ²The Hospital for Sick Children, Toronto, ON, Canada, ³Michigan State University, East Lansing, MI, ⁴Wright State University, Dayton, OH, ⁵The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁷The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, ⁸Spectrum Health, Grand Rapids, MI, ⁹Spectrum Health Helen DeVos Children's Hospital, Michigan State University, Grand Rapids, MI, ¹⁰Albert Einstein College of Medicine, White Plains, NY, ¹¹Children's Hospital at Montefiore, Bronx, NY, ¹²Seattle Children's Hospital, Seattle, WA, ¹³University of Alabama at Birmingham, Birmingham, AL, ¹⁴Metro Health, Grand Rapids, MI, ¹⁵Patient/Caregiver Co-Investigative Team, Grand Rapids, MI
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is often associated with symptoms such as fatigue, pain, and depressive symptoms that contribute to poor health-related quality of…
Abstract Number: 0635 • ACR Convergence 2022
Blood RNA-sequencing Reveals Complex Immune Dysregulation in ANA-positive Individuals with Distinct Profiles Preceding Progression to SLE versus Stable Autoimmunity
Lucy Marie Carter¹, Md Yuzaiful Md Yusof², Darren Plant³, Julien Bauer⁴, Stephanie Wenlock⁴, Adewonuola Alase¹, Antonios Psarras¹, Zoe Wigston¹ and Edward M Vital², ¹University of Leeds, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³The University of Manchester, Manchester, United Kingdom, ⁴University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Anti-nuclear antibody (ANA) positivity represents a complex ‘At-Risk’ state for development of connective tissue disease (CTD). ANA may become positive years in advance of…
Abstract Number: 0655 • ACR Convergence 2022
Proteomic Analysis of Histological Lesions Lupus Nephritis Identifies an Inflammatory Signature of Fibrous Crescents
Alessandra Ida Celia¹, Jeffery Hodgin², Avi Rosenberg³, Laurence S Magder⁴, Jill Buyon⁵, Betty Diamond⁶, Judith James⁷, William Apruzzese⁸, Paride Fenaroli⁹, Derek Fine¹, Jose Monroy-Trujillo¹, Mohamed G. Atta¹, Peter izmirly¹⁰, Michael Belmont⁵, Anne Davidson⁶, Daniel W. Goldman¹¹, the Accelerating Medicines Partnership (AMP) RA/SLE¹², Michelle Petri¹¹ and Andrea Fava¹, ¹Johns Hopkins University, Baltimore, MD, ²University of Michigan, Ann Arbor, MI, ³Johns Hopkins University, Ballwin, MO, ⁴University of Maryland, Department of Epidemiology and Public Health, Baltimore, MD, ⁵NYU Grossman School of Medicine, New York, NY, ⁶Feinstein Institutes for Medical Research, Manhasset, NY, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Brigham and Women's Hospital, Boston, MA, ⁹Università degli Studi di Parma, Parma, Emilia-Romagna, Italy, ¹⁰NYU Long Island School of Medicine, New York, NY, ¹¹Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, ¹²Multiple Insitutions
Background/Purpose: We employed urine proteomics to define the molecular signatures associated with the histological features quantified by the NIH activity and chronicity indices. Methods: Glomerular…
Abstract Number: 0715 • ACR Convergence 2022
Safety and Immunogenicity of Mixed COVID19 Vaccine Regimens in Immune-mediated Inflammatory Diseases: An Observational Cohort
Carol Hitchon¹, Christine Mesa², Charles N Bernstein¹, Catherine Card², RuthAnn Marrie¹, Sheila O'Brien³ and John Kim², ¹University of Manitoba, Winnipeg, MB, Canada, ²Public Health Agency of Canada, Winnipeg, MB, Canada, ³Canada Blood Services, Ottawa, Canada
Background/Purpose: Data on immunogenicity and safety of COVID-19 vaccination strategies exist for the general population, however, such data are limited for immunocompromised people including those…
Abstract Number: 0959 • ACR Convergence 2022
Assessing the Association Between Hydroxychloroquine and Preeclampsia Risk in SLE Pregnancies Using Administrative Claims Data
Amadeia Rector¹, Ivana Marić², Yashaar Chaichian³, Eliza Chakravarty⁴, Miranda Cantu⁵, Michael Weisman⁶, Gary Shaw⁷, Maurice Druzin⁷ and Julia Simard¹, ¹Stanford University School of Medicine, Palo Alto, CA, ²Stanford University, Stanford, ³Stanford University, Stanford, CA, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Global Lupus Support Group, Portage, MI, ⁶Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Stanford University School of Medicine, Palo Alto
Background/Purpose: Preeclampsia risk is higher among pregnancies in patients with systemic lupus erythematosus (SLE). Hydroxychloroquine (HCQ), a common first-line treatment, is encouraged in SLE pregnancies…
Abstract Number: 0980 • ACR Convergence 2022
The Effect and Outcomes of HCQ Alone and in Combination with Anti-Depressants on QTc
Kourtney Rudzinski¹, Zaina Shahid², Yasin kanakrieh², Saloni Goyal², Kyle Shaak² and James Ross³, ¹Lehigh Valley Health Network, Tatamy, PA, ²Lehigh Valley Health Network, Allentown, PA, ³lvhn, Macungie, PA
Background/Purpose: Hydroxychloroquine (HCQ) has faced increased scrutiny during the COVID pandemic for its association with QTc prolongation. In our field, patients are commonly on antidepressant…
Abstract Number: 0997 • ACR Convergence 2022
Withdrawal of Maintenance Glucocorticoid versus Other Immunosuppressants Among Patients with Systemic Lupus Erythematosus in Long Term Clinical Remission: Interim Analysis of a Non-inferiority Randomised Controlled Trial
Aishwarya Gopal¹, Chengappa Kavadichanda², Devender Bairwa³, Molly Mary Thabah⁴ and Vir Singh Negi⁵, ¹Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, Puducherry, India, ²JIPMER, Pondicherry, Puducherry, India, ³Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, Puducherry, India, ⁴JIPMER, Puducherry, Puducherry, India, ⁵AIIMS Bilaspur, Puducherry, Puducherry, India
Background/Purpose: Attempts to stop glucocorticoids among Systemic Lupus Erythematosus(SLE) patients in long term remission have been successful. Continuing other immunosuppressive (IS) agents indefinitely is currently…
Abstract Number: 1141 • ACR Convergence 2022
Consequences of SLE Heterogeneity on the Epigenome and the Drivers Behind
Olivia Castellini-Pérez¹, Athina Spiliopoulou², Guillermo Barturen¹, Andrii Iakovliev², Manuel Martinez-Bueno¹, Elena Carnero-Montoro¹ and Marta Alarcon-Riquelme¹, ¹Center for Genomics and Oncological Research (GENYO), Granada, Spain, ²University of Edinburgh, Edinburgh, Scotland, United Kingdom
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a prototypic systemic autoimmune disease characterized by a complex aetiology and heterogenous symptomatology which has been recently dissected using…
Abstract Number: 1352 • ACR Convergence 2022
Improving Completion Rates of Routine Mental Health Screening for Depression and Anxiety in Paediatric Lupus Outpatient Clinic to Enhance Patient Mental Health Care
Tala El Tal¹, Avery Longmore², Abdulaziz el Mutairi¹, Amani Al Bijadi¹, Audrea Chen¹, Holly Convery¹, Dinah Finkelstein³, Linda Hiraki⁴, Chetana Kulkarni⁵, Justine Ledochowski⁶, Neely Lerman¹, Karen Leslie⁷, Deborah Levy⁸, Sharon Lorber⁹, Jayne MacMahon¹⁰, Jeanine McColl¹¹, Sarah Mossad¹², Oscar Mwizerwa¹⁰, Lawrence Ng¹², Luana Flores Pereira¹², Vandana Rawal⁷, Alaa Shehab¹, Evelyn Smith¹³, Alene Toulany¹⁴ and Andrea Knight¹, ¹The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ²The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Department of Paediatrics, University of Toronto, ON, Canada, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, ⁵The Hospital for Sick Children, Division of Child & Youth Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁶The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, ⁷The Hospital for Sick Children, Division of Adolescent Medicine, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁹The Hospital for Sick Children, Factor Inwentash Faculty of Social Work, University of Toronto, Toronto, ON, Canada, ¹⁰The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, Toronto, ON, Canada, ¹¹University of Toronto, Toronto, ON, Canada, ¹²The Hospital for Sick Children, Toronto, ON, Canada, ¹³The Hospital for Sick Children, Division of Psychiatry, Department of Paediatrics, University of Toronto,, Toronto, ON, Canada, ¹⁴The Hospital for Sick Children, Division of Adolescent Medicine, Department of Paediatrics, University of Toronto,, Toronto, ON, Canada
Background/Purpose: Mental health (MH) problems are prevalent in adolescents with childhood-onset lupus (cSLE), with cross-sectional studies estimating prevalences of 20-60% for depression symptoms and 20-40%…

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