Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2316 • ACR Convergence 2023
Effect of SARS-CoV2 Infection on Disease Flares in Patients with Systemic Lupus Erythematosus: A Case-control Study
Chi Chiu Mok¹, Chris Cheung², Chi Hung To³, Kar Li Kelly Chan⁴ and SAU MEI TSE⁵, ¹Tuen Mun Hospital, Hong Kong, Hong Kong, ²Rutonjee Hospital, Hong Kong, Hong Kong, ³Pok Oi Hospital, Hong Kong, Hong Kong, ⁴Tuen Mun Hospital, Shatin, China, ⁵Tuen Mun Hospital, Hong Kong, China
Background/Purpose: To study the effect of SARS-CoV2 infection on disease flares in patients with systemic lupus erythematosus (SLE).Methods: Patients who fulfilled the ACR or SLICC…
Abstract Number: 2333 • ACR Convergence 2023
Dapirolizumab Pegol Impacts Important Immunologic Pathways in SLE: Pharmacodynamic Analysis of B Cell and Type I Interferon Pathways from a Phase 2b Trial
Ioana Cutcutache¹, Alex Powlesland¹, Andrew Skelton¹, Yunyun Sun¹, Matthew Page¹, George Stojan², Peter Lipsky³, Ania Skowera¹ and Christian Stach⁴, ¹UCB Pharma, Slough, United Kingdom, ²UCB, Baltimore, MD, ³AMPEL BioSolutions, Charlottesville, VA, ⁴UCB Pharma, Monheim am Rheim, Germany
Background/Purpose: The pivotal role of CD40-CD40L interactions in systemic lupus erythematosus (SLE) pathogenesis stems from the orchestration of a range of immune and inflammatory responses…
Abstract Number: 2443 • ACR Convergence 2023
Blockade of OX40/OX40L Signaling Using anti-OX40L Ameliorates Systemic Lupus Erythematosus
Junpeng Zhao¹, Liming Li¹, Xiwei Feng¹, Huiqi Yin¹ and Qianjin Lu², ¹Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China, ²Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Changsha, China
Background/Purpose: Genetic variations in the OX40 ligand (OX40L) locus have been implicated in the susceptibility to systemic lupus erythematosus (SLE). Notably, the blockade of OX40L…
Abstract Number: 2490 • ACR Convergence 2023
Safety and Efficacy of Mycophenolate Mofetil in New-onset Systemic Lupus Erythematosus with High Titer of Anti-dsDNA Antibody and Without Major Organ Involvement: A Multicenter Randomized Controlled Trial
Junna Ye¹, Yijun You², Zhuochao Zhou², Jingyi Wu², Fan wang² and Chengde Yang², ¹Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, ²Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Previous clinical trials of mycophenolate mofetil (MMF) in SLE were mainly focused on lupus nephritis (LN) (patients have been diagnosed with LN). In the…
Abstract Number: 2588 • ACR Convergence 2023
Updated Analyses of Cancer Incidence and Risk Factors in a Large International SLE Cohort
Sasha Bernatsky¹, Rosalind Ramsey-Goldman², Murray Urowitz³, John G. Hanly⁴, Caroline Gordon⁵, Michelle Petri⁶, Ellen Ginzler⁷, Daniel Wallace⁸, Sang-Cheol Bae⁹, Juanita Romero-Diaz¹⁰, Mary Anne Dooley¹¹, Christine Peschken¹², David Isenberg¹³, Anisur Rahman¹⁴, Susan Manzi¹⁵, Soren Jacobsen¹⁶, S. Sam Lim¹⁷, Ronald van Vollenhoven¹⁸, Ola Nived¹⁹, Diane L. Kamen²⁰, Cynthia Aranow²¹, Jill Buyon²², Guillermo Ruiz-Irastorza²³, Francisco Sanchez-Guerrero²⁴, Dafna Gladman²⁵, Paul R. Fortin²⁶, Jennifer LF Lee²⁷, Luck Lukusa²⁷, Graciela S Alarcón²⁸, Joan Merrill²⁹, Kenneth Kalunian³⁰, Manuel Ramos-Casals³¹, Kristjan Steinsson³², Asad Zoma³³, Anca Askanase³⁴, Munther Khamashta³⁵, Ian Bruce³⁶, Murat Inanç³⁷ and Ann Clarke³⁸, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Northwestern University, Chicago, IL, ³Schroeder Arthritis Institute, Krembil Research Institute; University of Toronto Lupus Clinic; Division of Rheumatology, Toronto, ON, Canada, ⁴Dalhousie University, Halifax, NS, Canada, ⁵Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁶Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, ⁷SUNY Downstate Health Sciences University, Brooklyn, NY, ⁸Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Hanyang University Hospital for Rheumatic Diseases and Hanyang University Institute for Rheumatology Research, Department of Rheumatology, Seoul, South Korea, ¹⁰Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ¹¹Raleigh Neurology Associates, Chapel Hill, NC, ¹²University of Manitoba, Winnipeg, MB, Canada, ¹³University College London, London, United Kingdom, ¹⁴Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ¹⁵Lupus Center of Excellence, Autoimmunity Institute, Allegheny Health Network, Pittsburgh, PA, ¹⁶Rigshospitalet, Copenhagen, Denmark, ¹⁷Emory University, Atlanta, GA, ¹⁸Amsterdam University Medical Centers, Amsterdam, Netherlands, ¹⁹Department of Rheumatology, Institution of Clinical Sciences, Lund University Hospital, Lund, Sweden, ²⁰Medical University of South Carolina, Charleston, SC, ²¹Feinstein Institutes for Medical Research, Manhasset, NY, ²²NYU Grossman School of Medicine, New York, NY, ²³Hospital Universitario Cruces, Barakaldo, Spain, ²⁴University Health Network/Sinai Health system, Toronto, ON, Canada, ²⁵Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, ²⁶Centre ARThrite - CHU de Québec - Université Laval, Quebec City, QC, Canada, ²⁷RI-MUHC, Montreal, QC, Canada, ²⁸Heersink School of Medicine. The University of Alabama at Birmingham, Birmingham, AL, ²⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ³⁰University of California San Diego, La Jolla, CA, ³¹Hospital Clinic, Barcelona, Barcelona, Spain, ³²Landspitali University Hospital, Reykjavik, Iceland, ³³Lanarkshire Centre for Rheumatology and Hairmyres Hospital, East Kilbride, East Kilbride, United Kingdom, ³⁴Columbia University Medical Center, New York, NY, ³⁵GSK Gulf, Medical Affairs Department, Dubai, United Arab Emirates, ³⁶University of Manchester, Manchester, United Kingdom, ³⁷Istanbul University, Istanbul, Turkey, ³⁸University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada
Background/Purpose: Many studies of cancer risk in SLE are limited by small sample size or use of administrative data, which rely on billing code diagnoses…
Abstract Number: 0014 • ACR Convergence 2023
The 330 Genetic Risk Loci of Systemic Lupus Erythematosus (SLE) Now Known Are Consonant with Multiple Causal Mechanisms Involving Epstein-Barr Virus (EBV)-Encoded Transcription Co-factors (TFs) in EBV-Infected B Cells
Viktoryia Laurynenka¹, Xiaoting Chen², sreeja Parameswaran², Leah Kottyan², Matthew Weirauch², Iouri Chepelev³, Kenneth Kaufman³ and John Harley³, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³US Department of Veterans Affairs Medical Center, Cincinnati, OH
Background/Purpose: Association of EBV infection with SLE, data suggesting an anti-EBNA1 molecular mimicry fostering SLE autoimmunity, and mechanisms in EBV infected B cells support a…
Abstract Number: 0135 • ACR Convergence 2023
Cancer Incidence and Risk Factors in Patients with Newly Diagnosed Systemic Lupus Erythematosus
Jung-Yong Han¹, Yena Jeon², Gaeun Kang², Sun-Young Jung³, Eun Jin Jang⁴, Soo-Kyung Cho⁵ and Yoon-Kyoung Sung⁵, ¹Hanyang University hospital for rheumatic disease, Seongdong-gu, Seoul, South Korea, ²Department of Statistics, Kyungpook National University, Daegu, South Korea, ³College of Pharmacy, Chung-Ang University, Seoul, South Korea, ⁴Department of Information Statistics, Andong National University, Andong, South Korea, ⁵Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: The increased cancer risk in patients with systemic lupus erythematosus (SLE) has received considerable attention. However, there is a lack of studies examining the…
Abstract Number: 0190 • ACR Convergence 2023
Racial Disparities in Self-reported Extent and Reasons for Nonadherence in SLE
Kai Sun¹, Londyn Robinson², Amanda Eudy³, Jennifer Rogers¹, Rebecca Sadun¹, Lisa Criscione-Schreiber⁴, Jayanth Doss¹ and Megan Clowse⁵, ¹Duke University, Durham, NC, ²University of Minnesota Medical School, Minneapolis, MN, ³Duke University, Raleigh, NC, ⁴Duke University School of Medicine, Durham, NC, ⁵Duke University, Chapel Hill, NC
Background/Purpose: Medication nonadherence is common in SLE and disproportionately affects Black patients. Nonadherence leads to increased hospitalizations, morbidity, and mortality and is a modifiable factor…
Abstract Number: 0544 • ACR Convergence 2023
Autoantibodies to dsDNA and Associated Proteins: Association with Proteinuria and Lupus Nephritis
Ranjan Gupta¹, Amita Aggarwal², Avinash Jain³, Liza Rajasekhar⁴, Chengappa Kavadichanda⁵, Vineeta Shobha⁶, Ashish J Mathew⁷, Parasar Ghosh⁸, Bidyut Das⁹ and Manish Rathi¹⁰, ¹All India Institute of Medical Sciences, New Delhi, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, ³SMS Medical College, Lucknow, India, ⁴Nizam's Institute of Medical Sciences, Madhapur, India, ⁵Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India, ⁶St. John's National Academy of Health Science, Bangalore, India, ⁷Christian Medical College, Vellore, India, ⁸Govt of West Bengal, Kolkata, India, ⁹SCB medical college, Cuttack, India, ¹⁰Postgraduate Institute of Medical education and Research, Chandigarh, India
Background/Purpose: Anti-dsDNA antibodies (ADA) are traditionally measured by ELISA and are associated with Lupus nephritis (LN). Testing by immunoline assay (IL) provides additional information on…
Abstract Number: 0561 • ACR Convergence 2023
Frequency of Anti-Ro Antibodies in Systemic Lupus Erythematosus Patients: Insights from Multicenter and National Registry
Lucia Margarita Mendoza Martinez¹, Joan Manuel Dapeña¹, Juan Manuel Bande¹, Maria Alejandra Medina¹, Silvia Papasidero¹, José caracciolo¹, Rosana Quintana², Lucila Garcia², Carla Andrea Gobbi², Sandy Sapag Durán², Alberto Spindler², Analia Patricia Alvarez², Cecilia Pisoni², Catalina Gomez², Raúl Hector Paniego², María Julia Santa cruz², Luciana Gonzalez Lucero², Rodrigo Aguila Maldonado², Sergio Gordon², Julia Romero², Gretel Rausch², Alberto Allievi², Alberto Omar Orden², johana zacariaz hereter³, Roberto Baéz², Andrea Vanesa González², Juan Manuel Vandale², Mario Alberto Goñi², Victor Caputo⁴, María Silvia Larroudé², Graciela Gómez², Josefina Marin², Victoria Collado², Gazzoni María Victoria², Marcos David Zelaya², Mónica Sacnún², Romina Rojas Tessel², Maira Alejandra Arias Saavedra², Maximiliano Machado Escobar², Pablo Astesana², Ursula Vanesa Paris², Bernando A. Pons-Estel² and Mercedes García⁵, ¹Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ²Study Group of the Argentine Society of Rheumatology for Systemic Lupus Erythematosus, Buenos Aires, Argentina, ³Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Hospital Militar Central, Buenos Aires, Argentina, ⁵Hospital Interzonal General de Agudos José de San Martín, La Plata, Argentina
Background/Purpose: Anti-Ro antibodies can be detected in 40% of patients with systemic lupus erythematosus (SLE) and have been associated with various clinical manifestations of the…
Abstract Number: 0579 • ACR Convergence 2023
Sub-types of Ischemic Stroke in Systemic Lupus Erythematosus,-associations with STAT4 and HLA-DRB1 Risk Genotypes
Liisa Hopia¹, Anna Laveskog², Dag Leonard³, Andreas Jonsen⁴, Johanna.T Gustafsson², Iva Gunnarsson⁵, Agneta Zickert⁶, Gunnel Nordmark⁷, Anders Bengtsson⁴, Leonid Padyukov⁸, Johanna Sandling³, Ann-Christine Syvänen⁹, Lars Rönnblom³, Magnus Andersson¹ and Elisabet Svenungsson⁶, ¹Department of Clinical Neuroscience, Unit of Neurology, Karolinska Institutet och Karolinska Universitetssjukhuset, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁴Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden, ⁵Department of Medicine Solna, Unit of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁶Department of Medicine Solna, Unit of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, ⁷Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ⁸Karolinska Institutet, Solna, Sweden, ⁹Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala, Sweden
Background/Purpose: Ischemic stroke is 2-3 times more common in patients with SLE as compared to the general population, and genetic susceptibility in the STAT4 and…
Abstract Number: 0596 • ACR Convergence 2023
Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in a Phase 2 Trial in Systemic Lupus Erythematosus (SLE): Achievement of Sustained SRI(4), BICLA and Dual Responses over 48 Weeks
Richard Furie¹, Cristina Arriens², Kenneth Kalunian³, Marilyn Pike⁴, Ronald van Vollenhoven⁵, Coburn Hobar⁶, Ayanbola Elegbe⁶, Samantha Pomponi⁶, Subhashis Banerjee⁶, Shalabh Singhal⁶, Thomas Wegman⁷ and Eric Morand⁸, ¹Northwell Health, Manhasset, NY, ²Oklahoma Medical Research Foundation and University of Oklahoma Health Sciences Center, Department of Arthritis & Clinical Immunology, Oklahoma City, OK, ³University of California San Diego, La Jolla, CA, ⁴MedPharm consulting, Inc., Raleigh, NC, ⁵Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁶Bristol Myers Squibb, Princeton, NJ, ⁷Bristol Myers Squibb, Beaver Falls, PA, ⁸Monash University, Centre for Inflammatory Diseases, Melbourne, Australia
Background/Purpose: Deucravacitinib is a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor approved in multiple countries for the treatment of adults with plaque psoriasis. In…
Abstract Number: 0740 • ACR Convergence 2023
Renal Arteriosclerosis in Index Lupus Nephritis Biopsies Predicts Future Cardiovascular Disease
Shivani Garg¹, Brad Astor², S. Sam Lim³, Amish Raval², Weixiong Zhong², Sarah Panzer², Brad Rovin⁴ and Christie M. Bartels², ¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin, School of Medicine and Public Health, Madison, WI, ³Emory University, Atlanta, GA, ⁴Ohio State University, Columbus, OH
Background/Purpose: Patients < 40 years old with lupus nephritis (LN) face 42-fold higher risk of cardiovascular disease (CVD) compared to peers. Traditional CVD risk calculators…
Abstract Number: 0888 • ACR Convergence 2023
Functionally Selective Immunomodulator Shows Robust Efficacy in Spontaneous Lupus Mouse Model
Helene ASNAGLI¹, Simon TESSIER¹, Martyn FOSTER², Sofie DENIES³, Eef HOEBEN⁴, Joël CROUZET¹ and Annegret VAN DER AA¹, ¹Ermium Therapeutics, Paris, France, ²Experimental Pathology Consultancy, Benfleet, United Kingdom, ³SD Analytics, Bellem, Belgium, ⁴2-Bridge, Zoersel, Belgium
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. There is still a high unmet need to improve current treatment options. Type 1…
Abstract Number: 0908 • ACR Convergence 2023
Association of Biologic Sex with Glycosphingolipids and the N-glycome in Lupus Nephritis and Renal Mesangial Cell Function
Tammy Nowling, bethany wolf, Calvin Blaschke, Richard Drake, Sandra Sanchez, Mariia Stefanenko, Mykhailo Fedoriuk, Oleg Palygin, Hongxia Bai and Jessalyn Rodgers, Medical University of South Carolina, Charleston, SC
Background/Purpose: SLE primarily afflicts women and many SLE patients develop nephritis, a serious complication of lupus. Identification of biomarkers and the pathogenic mechanisms underlying LN…

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