ACR Meeting Abstracts

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Abstracts tagged "Systemic lupus erythematosus (SLE)"

  • Abstract Number: 1786 • ACR Convergence 2024

    Select Immune Cell Dysregulation Identifies Clinically Quiescent Patients at Risk of Flare Who Stop Mycophenolate Mofetil While Continuing Hydroxychloroquine

    Christian Wright1, Rufei Lu2, Catriona Wagner3, Carla Guthridge4, Susan Macwana1, Eliza Chakravarty4, Tammy Utset5, Diane Kamen6, Gabriel Nicolas Contreras Martin7, William McCune8, Cynthia Aranow9, Kenneth Kalunian10, Elena Massarotti11, Megan Clowse12, Brad Rovin13, S. Sam Lim14, Vikas Majithia15, Richard Looney16, Maria Dall'Era17, Doruk Erkan18, Amit Saxena19, Nancy Olsen20, Kichul Ko21, Ellen Goldmuntz22, William Barry23, Ashley Pinckney24, ALE06 Clinical Study Team4, Judith James4 and Joel Guthridge4, 1Oklahoma Medical Research Foundation, Oklahoma City, 2University of California San Francisco, San Bruno, CA, 3Oklahoma Medical Research Foundation, Santa Cruz, CA, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5University of Chicago, Chicago, IL, 6Medical University of South Carolina, Charleston, SC, 7University of Miami, Key Biscayne, FL, 8U Michigan, Ann Arbor, MI, 9Feinstein Institutes for Medical Research, New York, NY, 10University of California San Diego, La Jolla, CA, 11Brigham and Women's Hospital, Boston, MA, 12Duke University, Chapel Hill, NC, 13The Ohio State University, Columbus, OH, 14Emory University, Atlanta, GA, 15Mayo Clinic Florida, Jacksonville, FL, 16University of Rochester, Rochester, NY, 17UCSF, Corte Madera, CA, 18Hospital for Special Surgery, New York, NY, 19NYU School of Medicine, New York, NY, 20Penn State University/Milton S Hershey, Hershey, PA, 21The University of Chicago, Chicago, IL, 22NIAID/ NIH, Washington, DC, 23Rho, Inc, Durham, NC, 24Rho, St Louis Park, NC

    Background/Purpose: Mycophenolate mofetil (MMF) is commonly used to treat major SLE manifestations; however, it is associated with significant toxicities. Thus, MMF withdrawal is desirable in…
  • Abstract Number: 1806 • ACR Convergence 2024

    Bisphenol a Methylation Scores Associate with SLE and ClinicalSubphenotypes

    Holme Vestin1, Nina Oparina2, Maija-Leena Eloranta1, Martina Frodlund3, Iva Gunnarsson4, Christopher Sjowall5, Elisabet Svenungsson6, Lars Rönnblom1, Ann-Christine Syvänen1, Johanna Sandling1, Juliana Imgenberg-Kreuz1 and Dag Leonard1, 1Uppsala university, Uppsala, Sweden, 2UU, Uppsala, Sweden, 3Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden, 4Karolinska Institute, Stockholm, Sweden, 5Linköping University, Linköping, Sweden, 6Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by production of auto-antibodies, immune complex formation and an activated type I interferon system. Both genetic and environmental…
  • Abstract Number: 1945 • ACR Convergence 2024

    The Bridge to Adult Care from Childhood for Young Adults with Rheumatic Disease (BACC YARD) Program, a Pediatric-to-Adult Rheumatology Transition Program: 2024 Updates

    John Bridges1, Eileen Rife2, Randy Cron3, Livie Timmerman4, Linda McAllister5, Annelle Reed6, Carolyn Smith7, Emily Smitherman3, Matthew Stoll3, Bethany Walker5 and Melissa Mannion3, 1University of Alabama at Birmingham/Children's of Alabama, Birmingham, AL, 2University of Alabama Birmingham, Vestavia Hills, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4University of Alabama at Birmingham, Gardendale, AL, 5Children's of Alabama, Trussville, AL, 6Children's of Alabama, Tuscaloosa, AL, 7Children's of Alabama, Birmingham, AL

    Background/Purpose: The transition period from pediatric to adult-oriented rheumatology care is a high-risk time for disease flare and poor outcomes.  We previously demonstrated implementation of…
  • Abstract Number: 2371 • ACR Convergence 2024

    The Role of Intracytoplasmic Toll- Like Receptors (TLR) and MyD88 in B Cell Subsets as Renal Response Predictors in Patients with Lupus Nephritis

    Fabiola Cassiano-Quezada1, José Jiram Torres-Ruiz2, Jennifer Balderas Miranda3, José Luis Maravillas-Montero4, Karina Santana-de Anda2, Beatriz Alcalá-Carmona5, Nancy R Mejía-Domínguez5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Guillermo Juarez-Vega4 and Diana Gomez-martin6, 1Department of Internal Medicine. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, 2Departament of Immunology and Rheumatology. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, 3Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 4Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: Recently, a gain of-function mutation within TLR7 was identified to induce SLE in a murine model and increased the survival of activated B lymphocytes,…
  • Abstract Number: 2388 • ACR Convergence 2024

    Racial/Ethnic Variation in Multimorbidity Risk and Accrual and Comorbid Conditions Among Patients with Systemic Lupus Erythematosus

    Katrina Williamson1, Herbert Heien2, Maria Stevens2, Cynthia Crowson2, Rozalina McCoy2 and Ali Duarte-Garcia2, 1Mayo Clinic Rochester, Rochester, MN, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have been shown to have increased burden of multimorbidity. Racial disparities in multimorbidity have also been shown repeatedly.…
  • Abstract Number: 2408 • ACR Convergence 2024

    Impact of Pain and Fatigue on Quality of Life Among Patients with Systemic Lupus Erythematosus

    Amanda Eudy1, Megan Clowse2, Meenakshi Jolly3, David Pisetsky4, Kai Sun5, Rebecca Sadun5, Lisa Criscione-Schreiber6, Mithu Maheswaranathan6, Jayanth Doss5 and Jennifer Rogers6, 1Duke University, Raleigh, NC, 2Duke University, Chapel Hill, NC, 3Rush University Medical Center, Chicago, 4Duke University Medical Center, Durham, NC, 5Duke University, Durham, NC, 6Duke University, Durham

    Background/Purpose: Our prior qualitative work discovered a subgroup of patients with SLE who experience persistent symptoms of fatigue and widespread pain, even on self-described “good…
  • Abstract Number: 2424 • ACR Convergence 2024

    Anifrolumab Effects on Response to Influenza Vaccine in SLE

    Cristina Arriens1, Anca Askanase2, Wambui Machua3, Fotios Koumpouras4, Ken Smith1, Joel Guthridge1, Judith James1 and Joan Merrill5, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Columbia University Medical Center, New York, NY, 3Piedmont Hospital Center, Atlanta, GA, 4Yale School of Medicine, New Haven, CT, 5Oklahoma Medical Research Foundation, Oklahoma City 73104, OK

    Background/Purpose: Risk for infections in systemic lupus may arise from immunosuppressant treatments or intrinsic immune defects. Disordered interferon signals are a hallmark of SLE. Anifrolumab, which…
  • Abstract Number: 2545 • ACR Convergence 2024

    Phosphodiesterase 1B Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation

    Shuhei Takeyama1, Michihito Kono1, Kohei Karino1, Yuki Kudo1, Masatoshi Kanda2, Hiroyuki Nakamura2, Kenichi Miyamoto1, Kazuro Kamada3, Maria Tada1, Ryo Hisada1, Yuichiro Fujieda1, Masaru Kato1, Olga Amengual4 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 2Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapprp, Japan, 4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe organ manifestations in SLE and is associated with poor quality of life. We…
  • Abstract Number: 2604 • ACR Convergence 2024

    Altered Expression of Ecto-5′-Nucleotidase (NT5E) in SLE Patients Based on Disease-associated Genotype

    Mikhail Olferiev1, Katherine Owen2, Peter Lipsky3 and Mary Crow1, 1Hospital for Special Surgery, New York, NY, 2RILITE, Charlottesville, VA, 3AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: The NT5E gene, encoding Ecto-5'-Nucleotidase/CD73, is expressed on the surface of immune system cells and is critical for converting AMP/IMP to adenosine/inosine, important immunosuppressive purine nucleosides.…
  • Abstract Number: PP15 • ACR Convergence 2024

    Breathing Mindfully and How to Control Anxiety in Lupus Patients

    Amanda Greene, Lupus Research Alliance, Los Angeles, CA

    Background/Purpose: For over four decades, Systemic Lupus Erythematosus has impacted my Quality of Life..  I was diagnosed in 1983- my entire life was changed.  I…
  • Abstract Number: 0092 • ACR Convergence 2024

    A New Generation Mesenchymal Stromal Cell (MSC)-based Cell Therapy Using Design of Experiments Halts Pristane Induced Glomerulosclerosis

    Hulya Bukulmez1, Adrienne Dennis2, kristine Highland3 and Steven N. Emancipator4, 1MetroHealth Medical Center, Case Western Reserve, Pepper Pike, OH, 2MetroHealth Medical Center, Case Western Reserve, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH, 4Case Western Reserve University, Cleveland, OH

    Background/Purpose: MSCs, exposed to a disease-specific cytokine profile, can accurately sense the composition of the inflammatory microenvironment. We have harnessed this adaptive ability of MSCs…
  • Abstract Number: 0167 • ACR Convergence 2024

    Epidemiology of Falls in a Diverse Cohort of Adults with SLE

    Laura Plantinga1, Charmayne M. Dunlop-Thomas2, Courtney Hoge3, Jinoos Yazdany4 and C. Barrett Bowling5, 1University of California, San Francisco, San Francisco, CA, 2Emory University School of Medicine, Department of Medicine, Division of Rheumatology, Atlanta, GA, 3Emory University, Atlanta, GA, 4UCSF, San Francisco, CA, 5Duke University, Durham, NC

    Background/Purpose: While often preventable, falls are a common, costly, and serious outcome in the U.S. population: more than one in four adults ³65 years old…
  • Abstract Number: 0191 • ACR Convergence 2024

    Beyond the Symptoms: Exploring Cognitive Bias in Lupus Diagnosis Within Primary Care

    Alyssa Howren1, Quan Le Tran1, Sadaf Sediqi1, Saadiya Hawa2, Eleni Linos1, Titilola Falasinnu3, Yashaar Chaichian1 and Julia Simard1, 1Stanford School of Medicine, Stanford, CA, 2Weiss Memorial Hospital, Chicago, IL, 3Stanford School of Medicine, Palo Alto, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune rheumatic disease whose prognosis varies by race and sex. To understand whether the cognitive processes of…
  • Abstract Number: 0353 • ACR Convergence 2024

    Identifying Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus-Based Approach

    Joy Buie1, Michael Fisher1, Hannah Tlydsley2, Kristen Backor2 and Karen Costenbader3, 1Lupus Foundation of America, Washington, DC, 2Charles River Associates, San Francisco, CA, 3Brigham and Women's Hospital/ Harvard Medical School, Boston, MA

    Background/Purpose: Health disparities among racial and ethnic minoritized individuals living with lupus remain a critical public health concern. Challenges related to healthcare affordability, accessibility, and…
  • Abstract Number: 0442 • ACR Convergence 2024

    Anti-U1-RNP Related Pregnancy Loss in Systemic Lupus Erythematosus

    Anam Nazir1, Joshua Reed2, Khalid Alghamdi2 and Catherine Ivory1, 1The Ottawa Hospital, Ottawa, ON, Canada, 2The Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) affects women of childbearing years and confers an increased risk of pregnancy complications. Risk of adverse events in pregnancy is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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