Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 0613 • ACR Convergence 2024
Prediction of Spontaneous Abortion in Women with Systemic Lupus Erythematosus (SLE) Based on Machine Learning Model: Insights from the Egyptian College of Rheumatology (ECR)–SLE Cohort
Nevin Hammam¹, Walaa N. Ismail², Iman I EL-Gazzar³, Osman Hammam⁴, Noha M Khalil⁵, Eman F Mohamed⁶, Nermeen Noshy⁷, Dina F El-Essawi⁸, Rawhya R El Shereef⁹, Faten Ismail⁹, Marwa ElKhalifa¹⁰, Hanan M Fathi¹¹, Soha Senara¹¹, Samar Tharwat¹², Samah I Nasef¹³, Amany R El-Najjar¹⁴, Ahmed M Abdalla¹⁵, Ali Bakhiet¹⁶, Ahmed Elsaman¹⁷ and Tamer A Gheita³, ¹Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt, Boston, MA, ²Faculty of Computers and Information, Minia University, Minia;, Minia, Egypt, ³Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, ⁴Department of Rheumatology and Rehabilitation, Faculty of Medicine, New Valley University, New Valley, Assiut, Egypt, ⁵Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt, ⁶Internal Medicine Department, Rheumatology Unit, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt, ⁷Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Ain-Shams University, Cairo, Egypt, ⁸Internal Medicine Department, Rheumatology Unit, Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt, ⁹Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt, ¹⁰Alexandria faculty of Medicine, Alexandria, Egypt, ¹¹Rheumatology Department, Faculty of Medicine, Fayoum University,, Fayoum, Egypt, ¹²Rheumatology Unit, Internal Medicine, Mansoura University, Dakahlia, ¹³Rheumatology Department, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt, ¹⁴Rheumatology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt, ¹⁵Rheumatology Department, Faculty of Medicine, Aswan University, Aswan, Egypt, ¹⁶Higher institute of Computer Science and Information Systems, Culture & Science City, Giza, Egypt, ¹⁷Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt
Background/Purpose: Systemic lupus erythematosus (SLE) predominantly affects women of childbearing period. SLE increases the risk of adverse pregnancy outcome including spontaneous abortion (SA), which causes emotional stress to…
Abstract Number: 0631 • ACR Convergence 2024
Impact of Baseline Proteinuria Level on Long-term Outcomes in Lupus Nephritis
Fadi Kharouf¹, Qixuan Li², Laura Patricia Whittall Garcia², Dafna Gladman³ and Zahi Touma⁴, ¹University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Proteinuria is a marker of lupus nephritis (LN) activity, damage, and response to therapy. There is still sparse evidence on the renal outcomes associated…
Abstract Number: 0650 • ACR Convergence 2024
Tubulointerstitial Inflammation Predicts Tubular Atrophy, Fibrosis, and Renal Function Loss in Lupus Nephritis
Yevgeniya Gartshteyn¹, Laura Geraldino², Shuwei Wang³, Vivette D'Agati¹ and Robert Winchester¹, ¹Columbia University Irving School of Medicine, New York, NY, ²Division of Rheumatology, Department of Medicine, Columbia University, New York, NY, ³Rutgers New Jersey Medical School, Newark, NJ
Background/Purpose: Current classification criteria of lupus nephritis (LN) emphasize glomerular pathology, however tubular atrophy and interstitial fibrosis (TAIF) are better predictors of poor…
Abstract Number: 0668 • ACR Convergence 2024
There Are No Shortcuts: Electronic Health Record-Generated Tool Does Not Reflect Medication Adherence in Patients with SLEin Bronx, NY
Kiera Brennan¹, Kai Sun², Anitha Ramu¹, Juliann Allen¹, Justina Shafik¹ and Noa Schwartz³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Duke University, Durham, NC, ³Albert Einstein College of Medicine, New York, NY
Background/Purpose: Nonadherence to hydroxychloroquine (HCQ) is associated with poor outcomes in SLE.1 Electronic Health Record (EHR) platforms collect data on patient medication access through dispensing…
Abstract Number: 0835 • ACR Convergence 2024
Effective Engineering of CD8+ T Cells from Autoimmune Disease Patients Utilizing a CD8-Targeted Lipid NanoparticleEncoding an Anti-CD19 CAR mRNA(CPTX2309)
Yan Zhang¹, Brittany Ross¹, Diana Galvan¹, Yanjie Bao¹, Daiki Matsuda¹, Shaun Grosskurth¹, Iago Pinal-Fernandez², Maria Casal-Dominguez³, Gregor Adams¹, Michael Rosenzweig¹, Ramin Farzaneh-Far¹, Priya Karmali¹, Adrian Bot¹, Andrew Mammen² and Haig Aghajanian¹, ¹Capstan Therapeutics, San Diego, CA, ²NIH, Bethesda, MD, ³NIH, Bathesda, MD
Background/Purpose: Ex vivo chimeric antigen receptor (CAR) T cell therapies have revolutionized cancer treatment and are demonstrating durable clinical efficacy in various autoimmune disease (AID)…
Abstract Number: 1006 • ACR Convergence 2024
Associations Between Rheumatic Diseases and Mental Health Disorders
Thoai Vu, Sivam Bhatt and Janet Lewis, University of Virginia, Charlottesville, VA
Background/Purpose: Rheumatic diseases are frequently linked to a reduced quality of life (QoL), particularly as disease severity escalates. Patients with rheumatic conditions often exhibit high…
Abstract Number: 1253 • ACR Convergence 2024
Patterns of Patient-reported Outcome Measures in Patients with Systemic Lupus Erythematosus with or Without Concurrent Fibromyalgia
Heather Gold¹, Yi Li¹, Rebecca Anthopolos¹, Peter Izmirly², Jill Buyon¹, Mala Masson³, Brooke Cohen¹, Kamil Barbour⁴, Amit Saxena⁵, H Michael Belmont⁵, Chung-E Tseng⁶ and Kelly Corbitt⁷, ¹NYU Grossman School of Medicine, New York, NY, ²New York University Grossman School of Medicine, New York, NY, ³NYU Langone Medical Center- Division of Rheumatology, New York, NY, ⁴CDC, Alpharetta, GA, ⁵NYU School of Medicine, New York, NY, ⁶NYU Langone Health, Flushing, NY, ⁷University of Miami Miller School of Medicine, El Portal, FL
Background/Purpose: Patients with SLE often have concomitant FM or symptoms similar to FM, including chronic pain, fatigue, sleep disturbance, and/or depression, potentially distinct from immune-mediated…
Abstract Number: 1280 • ACR Convergence 2024
Abnormal Cortical Gyrification Patterns in Adolescents with Childhood-onset SLE: Early Associations with Perceived Fatigue
Diana Valdes Cabrera¹, Tala El Tal², Santiago Arciniegas¹, Oscar Mwizerwa³, Asha Jeyanathan³, Lawrence Ng¹, Paris Moaf¹, Joanna Law⁴, Sarah Mossad⁵, Birgit Ertl-Wagner¹, Ann Yeh¹, Helen Branson¹, Adrienne Davis⁶, Linda Hiraki¹, Deborah Levy¹, Busi Zapparoli⁷, Ashley Danguecan⁸ and Andrea Knight⁹, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital For Sick Children & Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁵Hospital for Sick Children, Toronto, ON, Canada, ⁶Division of Pediatric Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁷The Hospital for Sick Children, Etobicoke, ON, Canada, ⁸The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Fatigue and brain fog are early complaints in adolescents with childhood-onset SLE (cSLE), who experience disease onset during a critical period of brain development.…
Abstract Number: 1495 • ACR Convergence 2024
Real-World Reduction in Disease Flares and Oral Corticosteroid Use with Anifrolumab Therapy in Systemic Lupus Erythematosus: A Claims-Based Study
Mawuena Binka¹, Rana Muhammad Qasim Khan², Joseph Tkacz³, Donna McMorrow³, Laurence Gozalo³ and Gail Kerr⁴, ¹BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, ²BioPharmaceuticals Medical, AstraZeneca, Wilmington, ³Inovalon, Bowie, MD, ⁴Veterans Affairs Medical Center, Georgetown and Howard University Hospitals, Washington, DC
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease characterized by frequent episodes of disease activity (flares) of varying severity.1 SLE flares are…
Abstract Number: 1511 • ACR Convergence 2024
Lupus Nephritis and Response to Treatment in Latin America
Rosana Quintana¹, Romina Nieto², Diana Carolina Fernández Ávila³, Rosa Serrano Morales⁴, Guillermina Harvey⁵, Lucia Hernandez⁶, Karen Roberts⁷, Marina Scolnik⁸, Carmen Funes Soaje⁹, Paula Alba¹⁰, Veronica Saurit¹¹, Mercedes Garcia¹², Guillermo Berbotto¹³, VERONICA BELLOMIO¹⁴, Wilfredo Patiño Grageda¹⁵, Graciela Gómez¹⁶, Cecilia Pisoni¹⁷, Ana Malvar¹⁸, Vicente Juarez¹⁹, Nilzio A. Da Silva²⁰, ODIRLEI MONTICIELO²¹, Henrique Ataide Mariz²², Francinne Machado Ribeiro²³, Eduardo Borba²⁴, Luciana Parente²⁴, Edgard Torres²⁵, Oscar Neira²⁶, Loreto Massardo²⁷, Gustavo Aroca Martínez²⁸, Carlos A. Cañas Davila²⁹, Gerardo Quintana López³⁰, Carlos Enrique Toro-Gutierrez³¹, Mario Moreno³², Andres Zuñiga³³, Miguel Angel Saavedra Salinas³⁴, Margarita Portela Hernandez³⁵, Hilda Fragoso-Loyo³⁶, Luis H. Silveira Torre³⁷, Ignacio García De La Torre³⁸, Carlos Abud Mendoza³⁹, Marcos Fonseca Hernández⁴⁰, Jorge Esquivel-Valerio⁴¹, Isabel Acosta Colman⁴², Jhonatan Losanto⁴³, Claudia Selene Mora Trujillo⁴⁴, Katiuzka Zuñiga Corrales⁴⁵, Roberto Muñoz Louis⁴⁶, Martin Rebella⁴⁷, Álvaro Danza⁴⁸ Manuel Ugarte-Gil⁴⁹, Graciela Alarcon⁵⁰, Urbano Sbarigia⁵¹, Federico Zazzetti⁵², Ashley Orillion⁵³, Guillermo Pons-Estel⁵⁴ and Bernardo Pons-Estel⁵⁴, ¹Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumaticas. GO-CREAR, Rosario, Santa Fe, Argentina, ³Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, Rosario, Argentina, ⁴Sanatorio Parque. Centro de Enfermedades Autoinmunes y Reumaticas del Grupo Oroao., Rosario, Argentina, ⁵Escuela de Estadística, Facultad de Ciencias Económicas y Estadística, Universidad Nacional de Rosario, Rosario, Argentina, Rosario, Argentina, ⁶Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), ROSARIO, Santa Fe, Argentina, ⁷Sección Reumatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁹Hospital Italiano, Cordoba, Argentina, ¹⁰Hospital Cordoba, Cordoba, Spain, ¹¹hospital privado universitario de cordoba, Córdoba, Argentina, ¹²HIGA San Martin, La Plata, Argentina, ¹³Unidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, ROSARIO, Argentina, ¹⁴Hospital Padilla, San Miguel de Tucumán, Argentina, ¹⁵Hospital General de Agudos Dr Ramos Mejia, CABA, Argentina, ¹⁶Instituto de Investigaciones Médicas Alfredo Lanari, Autónoma de Buenos Aires, Argentina, ¹⁷CEMIC, Buenos Aires, Argentina, ¹⁸Organización Médica de Investigación, Buenos Aires, Argentina, ¹⁹Hospital Señor del Milagro, Salta, Salta, Argentina, ²⁰Hospital das Clinicas, Universidad Federal de Goias, Goias, Goias, Brazil, ²¹HOSPITAL DE CLINICAS DE PORTO ALEGRE, PORTO ALEGRE, Rio Grande do Sul, Brazil, ²²Universidad Federal de Pernambuco, Pernambuco, Brazil, ²³Hospital Universitario Pedro Ernesto, UERJ, Rio De Janeiro, Brazil, Rio de Janeiro, Brazil, ²⁴Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, ²⁵Universidad Federal São Paulo, São Paulo, SP, Brazil, ²⁶Hospital del Salvador, Santiago de Chile, Chile, ²⁷Facultad de Medicina y Ciencia, Universidad San Sebastián, San Sebastián, Chile, ²⁸Universidad Simón Bolivar, Barranquilla, Colombia, Barranquilla, Colombia, ²⁹Fundación Valle del Lili, Unidad de Reumatología, Cali, Colombia, ³⁰Universidad de Los Andes, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia, ³¹Reference Center for Osteoporosis & Rheumatology, Cali, Colombia, ³²Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador, Guayaquil, Ecuador, ³³Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador, ³⁴División de Investigación en Salud, Hospital de Especialidades Dr. Antonio Fraga Mouret, CMN La Raza, CDMX, Mexico, ³⁵Departamento de Reumatología del Hospital de especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social (IMSS), Mexico, Mexico, ³⁶Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, ³⁷Department of Rheumatology , Instituto Nacional de Cardiología Ignacio Chávez., Mexico City, Mexico, ³⁸Depto. de Inmunología y Reumatología; Centro de Estudios de Investigación Básica y Clínica, Guadalajara, Mexico, ³⁹Hospital Central Dr. Ignacio Morones Prieto, SLP, México, SLP, Mexico, ⁴⁰Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosí, Mexico, ⁴¹Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, MONTERREY, Mexico, ⁴²Hospital de Clínicas I, Asunción, Paraguay, ⁴³Hospital de Clínicas I, San Lorenzo, Paraguay, ⁴⁴Hospital Nacional Edgardo Rebagliatti Martins, Lima, Peru, ⁴⁵Hospital Cayetano Heredia. Universidad Peruana Cayetano Heredia, Lima, Peru, ⁴⁶Hospital Docente Padre Billini, Santo Domingo, República Dominicana, Santo Domingo, Dominican Republic, ⁴⁷Unidad Enfermedades Autoinmunes Sistemicas, Clinica Medica C-Hospital de Clinicas, UDELAR Montevideo, Montevideo, Uruguay, ⁴⁸Médica Uruguaya Corporación de Asistencia Médica (MUCAM). Clínica Médica - Facultad de Medicina - UdelaR, Montevideo, Uruguay, ⁴⁹Universidad Cientifica del Sur, Lima, Lima, Peru, ⁵⁰The University of Alabama at Birmingham, Birmingham, AL, ⁵¹Johnson & Johnson Innovative Medicine, Brussels, Belgium, ⁵²Johnson & Johnson Innovative Medicine, Horsham, PA, PA, ⁵³Johnson & Johnson Innovative Medicine, Spring House, PA, PA, ⁵⁴Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina
Background/Purpose: The Latin American Group for the Study of Lupus (GLADEL) 2.0 is an observational prevalent and incident cohort of patients with systemic lupus erythematosus…
Abstract Number: 1528 • ACR Convergence 2024
Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: National Inpatient Sample Analysis
Maria Romero Noboa¹, Almurtada Razok², Husam El Sharu³ and Rafaella Litvin², ¹University of Alabama at Birmingham, Chicago, IL, ²John H Stroger Jr Hospital of Cook County, Chicago, IL, ³East Carolina University, Greenville, NC
Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to a range of pulmonary complications, including Pulmonary Arterial Hypertension (PAH), which affects between 0.5% and 17.5% of…
Abstract Number: 1548 • ACR Convergence 2024
Anifrolumab in Systemic Lupus Erythematosus. Spanish National Registry in a Real-world Setting
Carmen Secada Gómez¹, Vanesa Calvo-Rio², Miriam Retuerto Guerrero³, Judit Font⁴, Ivette Casafont-Sole⁵, Adrián Mayo-Juanatey⁶, Juan José Alegre Sancho⁶, Dalifer Freites Nuñez⁷, Cristina Hormigos⁸, Noemí Garrido-Puñal⁹, GUILLERMO GONZALEZ ARRIBAS¹⁰, Andrea García-Valle¹¹, Juan Roberto Miguelez Sanchez¹², Marta Ibáñez Martínez¹³, Fernando Lozano Morillo¹⁴, Ángel García Manzanares¹⁵, Sebastián Sandoval-Moreno¹⁶, Josefina Cortés-Hernández¹⁷, Desiree Palma¹⁸, Leticia Lojo Oliveira¹⁹, EVELIN CERVANTES PEREZ²⁰, PAZ COLLADO²¹, Cristina Arciniega Larios²², Luis Sala Icardo²³, Eztizen Labrador-Sánchez²⁴, Cilia Peralta Ginés²⁵, Nahia Plaza-Aulestia²⁶, Miguel Medina Malone²⁷, José Rosas-Gómez de Salazar²⁸, Montserrat Corteguera²⁹, Laura Cebrián¹⁹, Fred Anton Pages³⁰, JOSE RAMON LAMUA RIAZUELO³¹, maria Dolores Fábregas canales³², María José Alados Hernández³³, Marta Garijo Bufort³⁴, Anna Pamies Corts³⁵, Luis Sarabia De Ardanaz³⁶, Rodrigo Aguirre-del-Pino³⁷, José Ángel Cabezas Lefler³⁸, Álvaro Seijas-Lopez³⁷, Carmen Carrasco-Cubero³⁹, Ana López-Cerón Cofiño⁴⁰, Vera Ortiz-Santamaria⁴¹, Santos Castañeda⁴², María Laiño Piñeiro⁴³, Carmen Ordás Calvo⁴⁴, Celia Arconada Lopez⁴⁵, Carmen Bejerano⁴⁶ and Ricardo Blanco-Alonso⁴⁷, ANA URRUTICOECHEA⁴⁸, Blanca Garcia-Magallon⁴⁹, Ana Valeria Acosta Alfaro⁵⁰, Samuel Leal Rodriguez⁵¹, Marina Salido Olivares⁵² and Patricia Lavilla⁵³ ¹Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ²Valdecilla Hospital, Santander, Cantabria, Spain, ³Complejo Asistencial Universitario de León, Leon, Spain, ⁴Hospital Germans Trias i Pujol, Barcelona, Spain, ⁵Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁶Hospital Universitario Doctor Peset, Valencia, Spain, ⁷Hospital Clínico San Carlos. Madrid. Spain., Madrid, Spain, ⁸Hospital Clínico San Carlos, Madrid, Madrid, Spain, ⁹Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹⁰Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, ¹¹Hospital General Río Carrión, Palencia, Spain, ¹²Hospital Universitario de Móstoles, Madrid, Spain, ¹³Hospital Clínico Universitario de Salamanca, Salamanca, Spain, ¹⁴Hospital Central de La Defensa Gómez Ulla, Madrid, Spain, ¹⁵Hospital Universitario de Torrevieja, Alicante, Spain, ¹⁶Hospital Universitario Vall d´Hebrón, Barcelona, Spain, ¹⁷Hospital Universitario Vall d´Hebrón Hospitals, Barcelona, ES, Barcelona, Spain, ¹⁸Hospital Rafael Méndez, Lorca, Murcia, Spain, ¹⁹Hospital Universitario Infanta Leonor, Madrid, Spain, ²⁰Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Galicia, Spain, ²¹Hospital Universitario Severo Ochoa, MADRID, Spain, ²²Hospital de Mérida, Badajoz, Spain, ²³Hospital Universitario de Torrejón, Madrid, Spain, ²⁴Hospital General de La Rioja, Logroño, Spain, ²⁵Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain, ²⁶Hospital Galdakao, Vizcaya, Spain, ²⁷Hospital Calahorra, La Rioja, Spain, ²⁸Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, ²⁹ComplejoAsistencial de Ávila, Ávila, Spain, ³⁰Complejo Asistencial De Segovia, Segovia, Spain, ³¹Hospital Universitario del Henares, Madrid, Spain, ³²Hospital de Barbastro, Huesca, Spain, ³³Hospital Universitario Puerta del Mar, Cádiz, Spain, ³⁴Hospital de Sagunto, Valencia, Spain, ³⁵Hospital Verge de la Cinta, Tortosa, TARRAGONA, Spain, ³⁶Complejo Hospitalario de Jaén, Jaén, Spain, ³⁷Hospital Universitario Lucus Augusti, Lugo, Spain, ³⁸Complejo Asistencial de Zamora, Zamora, Spain, ³⁹Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, ⁴⁰Hospital Santa Bárbara, Soria, Spain, ⁴¹Hospital General de Granollers, Barcelona, Spain, ⁴²Hospital Universitario de la Princesa, Madrid, Spain, ⁴³Hospital Universitario de Navarra, Pamplona, Spain, ⁴⁴Hospital Universitario de Cabueñes, Gijón, Spain, ⁴⁵Hospital Universitario Infanta Elena, Valdemoro, Madrid, Spain, ⁴⁶Hospital Universitario Marques de Valdecilla, Immunopathology group, IDIVAL, Santander, Cantabria, Spain, ⁴⁷Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, ⁴⁸Hospital Universitario Son Espases, Palma de Mallorca, Islas Baleares, Spain, ⁴⁹Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, ⁵⁰Hospital Universitario Infanta Sofía, Madrid, Spain, ⁵¹HUP La Fe, Valencia, Spain, ⁵²Hospital Infanta Cristina, Parla, Spain, ⁵³Hospital General de Villalba, Collado Villalba, Spain
Background/Purpose: Anifrolumab (ANI) is a human monoclonal antibody that binds to the type I interferon receptor subunit 1 (IFNAR1), thus blocking the biological activity of…
Abstract Number: 1687 • ACR Convergence 2024
IgG and IgA anti-LIN28A Outperform Anti-dsDNA and anti-Sm in Distinguishing SLE from Health and Other Autoimmune Diseases
Ioannis Parodis¹, Dionysis Nikolopoulos², Julius Lindblom³, Denis Lagutkin³, Lorenzo Beretta⁴, Maria Orietta Borghi⁵, Janique Peyper⁶, Guillermo Barturen⁷, Per-Johan Jakobsson³, Marta Alarcon-Riquelme⁸, Natalia Sherina³ and Helena Idborg⁹, and PRECISESADS Clinical Consortium, ¹Karolinska Institutet, Karolinska University Hospital; Örebro University, Solna, Sweden, ²Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, ³Karolinska Institutet, Stockholm, Sweden, ⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MIlano, Milan, Milan, Italy, ⁵Università degli Studi di Milano Statale, Milano, Italy, ⁶Sengenics Corporation Pte Ltd, Singapore, Singapore, ⁷Center for Genomics and Oncological Research (GENYO), Andalusia, Spain, ⁸Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ⁹Karolinska Institutet, Solna, Sweden
Background/Purpose: Systemic lupus erythematosus (SLE) is characterised by the production of a multitude of autoantibodies (abs). The diagnosis of SLE is supported by the presence…
Abstract Number: 1770 • ACR Convergence 2024
Assessing S100A4 and Myofibroblast Phenotypes in the Pathogenesis of Cardiac and Cutaneous Neonatal Lupus
Nalani Sachan¹, Christina Firl², Philip Carlucci³, Nicola Fraser², Robert Clancy⁴ and Jill Buyon⁵, ¹NYU Grossman School of Medicine, New York, NY, ²NYU Langone Health, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Columbia University Medical Center, New York, NY, ⁵New York University Grossman School of Medicine, New York, NY
Background/Purpose: Neonatal lupus (NL), driven by fetal exposure to maternal anti-SSA/Ro autoantibodies, typically results in permanent cardiac manifestations in utero and/or a transient rash postnatally.…
Abstract Number: 1799 • ACR Convergence 2024
In VitroEvidence for the Restoration of Glucocorticoid Sensitivity by Toll-Like Receptor 7 and 8 Inhibition in Systemic Lupus Erythematosus
Jia Xin Chow¹, Rochelle Sherlock², Taylah Bennett², Eric Morand³ and Sarah Jones², ¹Monash University, Melbourne, Victoria, Australia, ²Monash University, Melbourne, Australia, ³School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia
Background/Purpose: The strategy of inhibiting toll-like receptors (TLR) 7 and 8 is being evaluated in clinical trials in systemic lupus erythematosus (SLE) to assess its…

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