Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 1467 • ACR Convergence 2025
Risk Factors Associated with Chronic Kidney Disease and End-Stage Kidney Disease in Patients with Newly Diagnosed Lupus Nephritis
Aakash V. Patel¹, Lingxiao Zhang², Hyon K. Choi³ and April Jorge⁴, ¹Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, ³MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA, ⁴Massachusetts General Hospital, Boston, MA

Background/Purpose: Lupus nephritis (LN) affects over half of patients with systemic lupus erythematosus (SLE) and is associated with an increased risk for adverse kidney outcomes.…
Abstract Number: 1270 • ACR Convergence 2025
Increasing Participation in the FT819 Cell Therapy Trial Amongst People Living with Lupus: A Focus Group Study
Joy Buie¹, Safoah Agyemang¹, Andrew Henry², Andrew BitMansour³, Vaneet Sandhu⁴, Debra Zack⁵ and Michael Fisher¹, ¹Lupus Foundation of America, Washington, DC, ²Fate Therapeutics, Inc., San Diego, CA, ³Fate Therapeutics, Inc., San Carlos, CA, ⁴Fate Therapeutics, Inc., San Diego, ⁵Fate Therapeutics, San Diego
Background/Purpose: Clinical trials exploring the safety and efficacy of chimeric antigen receptor (CAR) T-cell therapy for lupus are growing. Challenges linked to recruitment for CAR…
Abstract Number: 1078 • ACR Convergence 2025
Trends in Hospitalization rate with Lupus in the State of Florida: A retrospective data review from Florida Health Charts from 1992-2023
Muhammad Sohaib Asghar¹, Mohammed Akram², Veerkaran Banga¹, rajkaran Banga¹, Woo Joo Lee¹, Afsana Ansari Shaik³, Syed Muhammad Muneeb Akhtar⁴ and Thomas Shimshak¹, ¹AdventHealth Sebring, Sebring, FL, ²HCA Aventura, Aventura, FL, ³Mayo Clinic, Rochester, MN, ⁴Dow University of Health Sciences, Karachi, Pakistan
Background/Purpose: Lupus is a systemic autoimmune disease that occurs when the body's immune system attacks its own tissues and organs. This study was conducted to…
Abstract Number: 0947 • ACR Convergence 2025
Mechanisms of anti-NMDAR antibody-mediated neuronal pathology and mitigation by angiotensin II signaling inhibition
Kaitlin Carroll¹, Mark Mizrachi¹, Sean Simmons², Bahtiyar Toz¹, Czeslawa Kowal³, Nazila Tehrani¹, Aida Zarfeshani¹, Nina Kello¹, Lara El Khoury⁴, Jeffrey Wingard¹, Rachel Weissman-Tsukamoto³, Joshua Levin², Bruce Volpe³ and Betty Diamond⁵, ¹Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Manhasset, NY, ²Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, ³Feinstein Institute of Molecular Medicine, Manhasset, NY, ⁴Zucker School of Medicine at Hofstra/Northwell Health, Great Neck, NY, ⁵The Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Cognitive impairment is a frequent manifestation of neuropsychiatric systemic lupus erythematosus, present in up to 80% of patients and leading to a diminished quality…
Abstract Number: 0906 • ACR Convergence 2025
Preclinical Characterization of IBI3034, an TACI and BCMA Chimeric Fc Fusion Protein, that Potently Modulates B Lymphocytes and Serum Immunoglobulin for the Treatment of B cell Related Autoimmune Disease
Yao Xiong, Shuaixiang Zhou, Zhimin Zhang, Bin Li, Zhihao Ming, Yuyu Wu, Liu Li, Chang Li, Fenggen Fu, Zhihai Wu, Shun Wang, Guogang Yuan, Yuling Song, Jinyang Li, Huizhong Xiong and Bingliang Chen, Innovent Biologics (Suzhou) Co., Ltd., Suzhou, Jiangsu, China (People's Republic)
Background/Purpose: Dysregulated B-cell activation plays a pivotal role in the pathogenesis of various autoimmune diseases. B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are…
Abstract Number: 0652 • ACR Convergence 2025
Evolution and Readiness: Preparing for Cell Therapy in Lupus Trials, A LuCIN Network Evaluation
Brandon Jackson¹, Saira Sheikh², Roberto Caricchio³, Taylor Irons⁴, Maria Dall'Era⁵, Amit Saxena⁶, Alfred Kim⁷, Jose Rubio⁸, Sasha Bernatsky⁹, David Goddard¹⁰, Fotios Koumpouras¹¹, Aimee Williams¹², Maya Merrell¹³, Jennifer Meriwether¹⁴ and Stacie Bell¹⁵, ¹Lupus Therapeutics, Miami, FL, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of Massachusetts Chan Medical School, Worcester, MA, ⁴Lupus Therapeutics, Houston, TX, ⁵Division of Rheumatology, University of California, San Francisco, CA, ⁶NYU Grossman School of Medicine, New York, NY, ⁷Washington University School of Medicine, St. Louis, MO, ⁸University of Alabama at Birmingham, Hoover, AL, ⁹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹⁰NYU Langone Grossman SOM, Brooklyn, NY, ¹¹Yale School of Medicine, New Haven, CT, ¹²Lupus Therapeutics, Raleigh, NC, ¹³Lupus Therapeutics, Charleston, SC, ¹⁴Lupus Therapeutics, Westminster, CO, ¹⁵Lupus Therapeutics, Lakewood, CO
Background/Purpose: Lupus Therapeutics (LT), the clinical affiliate of the Lupus Research Alliance, oversees the premier North American Lupus Clinical Investigators Network (LuCIN). As cell therapy…
Abstract Number: 0631 • ACR Convergence 2025
Antibodies to Type I and Type III Interferons at Diagnosis Predispose to Serious Infections on Follow Up in an Inception cohort of SLE (INSPIRE) from India.
Rudrarpan Chatterjee¹, Komal Singh², Ranjan Gupta³, Sudhir Sinha⁴ and Amita Aggarwal⁵, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow., Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ³All India Institute of Medical Sciences, New Delhi, Delhi, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, India, ⁵Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are predisposed to infections due to immune dysregulation. Autoantibodies to cytokines can cause serious infections, including severe COVID-19,…
Abstract Number: 0613 • ACR Convergence 2025
A Baseline Kidney Biopsy Is Not Always Feasible in Incident Lupus Nephritis: Insights From an Inception Cohort
Fadi Kharouf¹, Pankti Mehta², Qixuan Li³, Dafna D. Gladman⁴, Zahi Touma⁵ and Laura Whitall Garcia⁶, ¹University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ²University of Toronto, Gladman Krembil Psoriatic Arthritis Research Program, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Division of Rheumatology, Toronto, ON, Canada, ⁵University of Toronto, Toronto, ON, Canada, ⁶University Health Network, Toronto, ON, Canada
Background/Purpose: Baseline kidney biopsy is the gold standard for diagnosing incident lupus nephritis (LN). However, in certain cases, obtaining a biopsy may not be feasible…
Abstract Number: 0597 • ACR Convergence 2025
Low 25-hydroxyvitamin D Levels are Associated with Higher Mortality and More Cardiovascular Events in Systemic Lupus Erythematosus
Theerada Assawasaksakul¹, Andrea Fava², Daniel Goldman³, Laurence Magder⁴ and Michelle Petri³, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Johns Hopkins University School of Medicine, Timonium, MD, ⁴University of Maryland, Baltimore, Baltimore, MD
Background/Purpose: No studies have directly examined the link between 25-hydroxyvitamin D [25(OH)D] and cardiovascular outcomes in SLE. This study aimed to assess this association, hypothesizing…
Abstract Number: 0803 • ACR Convergence 2025
Improved Efficacy and Safety Outcomes in Patients with SLE Treated with Belimumab (BEL) Versus Immunosuppressants (IS), in Addition to Antimalarials (AM) and Glucocorticoids (GC): A Post Hoc Summary of Five Phase 3 Trials
Mariele Gatto¹, Karen H. Costenbader², Andreas Schwarting³, Julia Harris⁴, Ciara O'Shea⁵, Roger A. Levy⁶ and Andrea Doria⁷, ¹Academic Rheumatology Centre, Department of Clinical and Biological Sciences, University of Turin, Mauriziano Hospital, Turin, Italy, ²Harvard Medical School and Brigham and Women's Hospital, Boston, MA, ³Johannes Gutenberg University Mainz, University Medical Centre, Mainz, Germany, ⁴GSK, Biostatistics, London, United Kingdom, ⁵Global Medical Affairs, GSK, Dublin, Ireland, ⁶GSK, Specialty Care, Global Medical Affairs, Collegeville, PA, ⁷University of Padova, Padova, Italy
Background/Purpose: Chronic GC and IS use increases damage accrual and mortality. The 2023 EULAR SLE recommendations support initiation of biologics such as BEL, a human…
Abstract Number: 0232 • ACR Convergence 2025
Hydroxychloroquine Blood Testing in Lupus: The Michigan Medicine Experience
Zeinab Saleh¹, Michelle Kahlenberg², Wendy Marder¹ and Emily Somers¹, ¹University of Michigan, Ann Arbor, MI, ²Michigan Medicine, Ann Arbor, MI
Background/Purpose: Measuring hydroxychloroquine (HCQ) blood levels in patients with systemic lupus erythematosus (SLE) can assess medication adherence and determine whether concentrations fall within the therapeutic…
Abstract Number: 0036 • ACR Convergence 2025
Integrated Analysis of Polygenic and Environmental Risk Scores for Late-Onset Systemic Lupus Erythematosus
Mehmet Hocaoglu¹ and Amr Sawalha², ¹University of Pittsburgh Medical Center, Piitsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Polygenic risk scores (PRS) have been constructed to summarize genetic risk but there is limited research on environment-wide analysis of risk factors for systemic…
Abstract Number: 2695 • ACR Convergence 2025
B-cell depletion and lymphoid follicle disruption upon different B-cell depleting agents
Carlo Tur¹, Markus Eckstein², Laura Bucci¹, Janina Auth³, Christina Bergmann¹, Simon Rauber⁴, Melanie Hagen¹, Danae-Mona Nöthling¹, Sebastian Böltz¹, Andreas Wirsching¹, Filippo Fagni⁵, Giulia Corte⁶, Panagiotis Garantziotis¹, Jule Taubmann⁷, jochen wacker¹, Andreas Ramming⁸, Maria Antonietta D'Agostino⁹, Arndt Hartmann¹⁰, Fabian Müller¹¹, Andreas Mackensen¹², Ricardo Grieshaber-Bouyer¹³, Georg Schett¹⁴, Aline Bozec¹ and Maria Gabriella Raimondo¹, ¹Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ²Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, ³Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, ⁴Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Bayern, Germany, ⁵Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Bayern, Germany, ⁶- Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, ⁷Department of Medicine ³ - Rheumatology and Immunology, Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department of Internal Medicine ³, Rheumatology & Immunology, Friedrich-Alexander-University (FAU) & Universitätsklinikum Erlangen, Erlangen, Germany, ⁹Division of Rheumatology and Clinical Immunology - Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ¹⁰Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander- Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, ¹¹University Hospital of Erlangen, Erlangen, Germany, ¹²Department of Medicine ⁵ - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Uniklinikum Erlangen, Erlangen, Germany, ¹³University Hospital Erlangen, Erlangen, Germany, ¹⁴Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, Erlangen, Germany
Background/Purpose: Advanced protein-based therapies targeting B-cells, including glycoengineered CD20 monoclonal antibody obinutuzumab (OBI) and the CD19/CD3 T-cell engager blinatumumab (BLI), show promise for managing severe…
Abstract Number: 2629 • ACR Convergence 2025
Predictors of 30-day Readmissions in Pregnant Patients with Systemic Lupus Erythematosus: The Impact of Social Determinants of Health.
Sandhya Kannayiram¹, Yiyuan Wu², Lisa Sammaritano³, Michael Lockshin⁴, Rich Caruana⁵, Ware Branch⁶, Jane Salmon³ and Bella Mehta⁷, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵Microsoft, Redmond, WA, ⁶University of Utah Health Sciences Center, Salt Lake City, UT, ⁷Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ
Background/Purpose: Social Determinants of Health (SDOH) are increasingly recognized as significant contributors to adverse outcomes in pregnant patients with SLE. This study aims to evaluate…
Abstract Number: 2469 • ACR Convergence 2025
Development of Consensus Statements on Glucocorticoid Use in Systemic Lupus Erythematosus
Heh Shiang Sheu¹, Wen Nan Huang¹, Yao-Fan Fang², Tai-Ju Lee³, Ling-Ying Lu⁴, Ming-Han Chen⁵, Der-Yuan Chen⁶, Fu-Chiang Yeh⁷, Yu-Wan Liao¹, Chang-Youh Tsai⁸, Tsu-Yi Hsieh¹, Song-Chou Hsieh⁹, Shue-Fen Luo², Yu-Jih Su¹⁰, Yeong-Jian Jan Wu¹¹ and Chun chi Lu¹², ¹Taichung Veterans General Hospital, Taichung, Taichung, Taiwan (Republic of China), ²Chang Gung Memorial Hospital, Taoyuan, Taoyuan, Taiwan (Republic of China), ³National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan (Republic of China), ⁴Kaohsiung Veterans General Hospital, Kaohsiung, Kaohsiung, Taiwan (Republic of China), ⁵Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan (Republic of China), ⁶China Medical University Hospital, Taichung, Taichung, Taiwan (Republic of China), ⁷Tri-Service General Hospital, Taipei, Taipei, Taiwan (Republic of China), ⁸Fu Jen Catholic University Hospital, New Taipei, New Taipei, Taiwan (Republic of China), ⁹National Taiwan Unuversity Hospital, Taipei City, Taiwan (Republic of China), ¹⁰Chang Gung Memorial Hospital, Kaohsiung, Kaohsiung, Taiwan (Republic of China), ¹¹Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan (Republic of China), ¹²¹. Tri-Service General Hospital, Taipei, Taiwan ². Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan, Taipei, Taiwan (Republic of China)
Background/Purpose: Systemic glucocorticoid (GC) therapy is indispensable for treating active systemic lupus erythematosus (SLE) and lupus nephritis (LN), while contributing significantly to comorbidities and irreversible…

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