ACR Meeting Abstracts

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Abstracts tagged "Systemic lupus erythematosus (SLE)"

  • Abstract Number: 1764 • ACR Convergence 2024

    Reduction in Circulating Neutrophil Extracellular Traps and Restored Degradation Post-treatment in Pediatric Lupus

    Tatiana Borja1, Bharati Matta2, Lydia Thomas3, Jenna Battaglia4, Amanda Huang5, Kim Simpfendorfer6, Hongxiu Wen5, Joyce Hui-Yuen7, Boris Reizis8, Sohei Makita8 and Betsy Barnes5, 1Northwell- Cohen Children's Medical Center, Elmhurst, NY, 2The Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell Health - Cohen Children's Medical Center, Lake Success, NY, 4Feinstein Institutes for Medical Science, Manhasset, 5Feinstein Institutes for Medical Science, Manhasset, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Northwell Health, Cohen Children's Medical Center, Great Neck, NY, 8New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Pediatric lupus (pSLE) is a multisystemic, chronic, autoimmune disease in which over 50% of pSLE patients develop lupus nephritis (pLN). Neutrophil extracellular traps (NETs)…
  • Abstract Number: 1798 • ACR Convergence 2024

    CXCL6 Synthesized by Proximal Tubule Cells May Promote Fibrosis in Lupus Nephritis

    Philip Carlucci1, Nalani Sachan2, Andrea Fava3, Brooke Cohen2, Jasmine Shwetar4, Siddarth Gurajala5, Qian Xiao5, Joseph Mears6, Katie Preisinger2, Devyn Zaminski7, Kristina Deonaraine8, Peter Izmirly9, Judith James10, Joel Guthridge10, Wade DeJager11, David Wofsy12, Cynthia Loomis2, Gyles Ward2, Ming Wu13, Chaim Putterman14, Deepak Rao15, Betty Diamond16, Derek Fine17, Jose Monroy-Trujillo17, H Michael Belmont7, William Apruzzese18, Anne Davidson19, Richard Furie20, Paul Hoover21, Celine Berthier22, Maria Dall'Era23, Diane Kamen24, Kenneth Kalunian25, Jennifer Anolik26, Jennifer Barnas27, Arnon Arazi28, Soumya Raychaudhuri29, Nir Hacohen30, Robert Clancy31, Kelly Ruggles32, Michelle Petri33 and Jill Buyon2, and the Accelerating Medicines Partnership in RA/SLE, 1New York University School of Medicine, New York, NY, 2NYU Grossman School of Medicine, New York, NY, 3Johns Hopkins University, Baltimore, MD, 4New York School of Medicine, Ann Arbor, MI, 5Harvard Medical School, Boston, MA, 6Michigan University, Ann Arbor, MI, 7NYU School of Medicine, New York, NY, 8Jacobs School of Medicine, University at Buffalo, Buffalo, NY, 9New York University Grossman School of Medicine, New York, NY, 10Oklahoma Medical Research Foundation, Oklahoma City, OK, 11Oklahoma Medical Research Foundation, Oklahoma City, 12University of California San Francisco, SF, CA, 13Northwell, New York, NY, 14Albert Einstein College of Medicine, Safed, Israel, 15Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 16The Feinstein Institutes for Medical Research, Manhasset, NY, 17Johns Hopkins School of Medicine, Baltimore, MD, 18Brigham and Women's Hospital, Everett, MA, 19Feinstein Institutes for Medical Research, Manhasset, NY, 20Northwell Health, Manhasset, NY, 21Brigham and Women's Hospital, SWAMPSCOTT, MA, 22University of Michigan, Ann Arbor, MI, 23UCSF, Corte Madera, CA, 24Medical University of South Carolina, Charleston, SC, 25University of California San Diego, La Jolla, CA, 26University of Rochester Medical Center, Rochester, NY, 27University of Rochester, Rochester, NY, 28Feinstein Institutes for Medical Research, Melrose, MA, 29Brigham and Women's Hospital, Boston, MA, 30Broad Institute of MIT and Harvard, Boston, MA, 31Columbia University Medical Center, New York, NY, 32NYU Grossman School of Medicine, Brooklyn, NY, 33Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Detection of urinary CXCL6, a member of the IL-8 chemokine family, has been linked to CKD and is a proposed marker of chronic damage…
  • Abstract Number: 1863 • ACR Convergence 2024

    Human Endogenous Retroviruses Promote the Aberrant T Cell Differentiation in Systemic Lupus Erythematosus

    Xiaoli Min1, Jiali Wu2, Yaqin Yu3, Qianjin Lu4 and Ming Zhao4, 1Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China (People's Republic), 2Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic), 3Central South University, Changsha, China (People's Republic), 4Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China (People's Republic)

    Background/Purpose: Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs and systems. The complex pathogenesis of SLE involved the abnormal activation of CD4+T cells and DNA hypomethylation modification. Human endogenous retroviruses (HERVs)…
  • Abstract Number: 2167 • ACR Convergence 2024

    Trust and Shared Decision-Making in Adolescents with Systemic Lupus Erythematosus: Findings from a Pilot Survey Design Study

    Hayley M Lynch1, Jon Burnham2, Joyce Chang3, Mackenzie McGill2, Nellie P Butler2 and Sabrina Gmuca2, 1Seattle Children's Hospital, Seattle, WA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Boston Children's Hospital, Brookline, MA

    Background/Purpose: The lifelong nature of pediatric systemic lupus erythematosus (SLE) necessitates longitudinal doctor-patient relationships, and existing research in adult populations has demonstrated that aspects of…
  • Abstract Number: 2382 • ACR Convergence 2024

    Utility of Urinary Biomarkers to Predict Long-term Renal Outcomes in Lupus Nephritis

    Ryan Baker1, Laura Patricia Whittall Garcia1, Michael Kim1, Dennisse Bonilla1, Murray Urowitz2, Dafna Gladman3, Zahi Touma4 and Joan Wither1, 1University Health Network, Toronto, ON, Canada, 2Self employed, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4University of Toronto, Toronto, ON, Canada

    Background/Purpose: Lupus nephritis (LN) affects up to 50% of patients with Systemic Lupus Erythematosus. Around 40% of patients will experience a subsequent renal flare in…
  • Abstract Number: 2401 • ACR Convergence 2024

    A Novel Modeling Approach to Elucidate the Role of Autoantibodies in Complement Activation in SLE

    David Pisetsky1, Yuankang Zhao2, Matthew Engelhard3, Amanda Eudy4, Philip Tedeschi5, Alex Verdone5, Megan Clowse6, Lisa Criscione-Schreiber2, Jayanth Doss3, Mithu Maheswaranathan2, Rebecca Sadun3, Kai Sun3 and Jennifer Rogers2, 1Duke University Medical Center, Durham, NC, 2Duke University, Durham, 3Duke University, Durham, NC, 4Duke University, Raleigh, NC, 5Immunovant, Inc, New York, NY, 6Duke University, Chapel Hill, NC

    Background/Purpose: In SLE, ANAs can promote pathogenesis by forming immune complexes (ICs) that activate complement.  While antibodies to DNA (anti-DNA) are known to be associated…
  • Abstract Number: 2418 • ACR Convergence 2024

    Identification of Co-expressed Molecular Markers That Predict Risk of Severe Flare in Patients with Systemic Lupus Erythematosus (SLE)

    Matthew Linnik1, Guilherme Rocha2, David Gemperline3, Ernst Dow3, Christoph Preuss3, Helen Masson4, Olivia Ellis4, Ana Accioly3, Maja Hojnik5, Kira Rubtsova1, Robert Benschop6, Mark Chambers7, Mark Genovese3 and Richard Higgs3, 1Eli Lilly, San Diego, CA, 2Eli Lilly, Indianapolis, IN, 3Eli Lilly and Co, Indianapolis, IN, 4Eli Lilly and Co, San Diego, CA, 5Eli Lilly and Co., Indianapolis, IN, 6Eli Lilly and Company, Indianapolis, IN, 7Eli Lilly, Zionsville, IN

    Background/Purpose: SLE flare is a clinically and regulatory relevant outcome, yet limited markers currently exist that predict its risk. We used baseline whole blood/serum samples…
  • Abstract Number: 2435 • ACR Convergence 2024

    Attainment of Remission, Use of Immunomodulatory/suppressive Agents and Gradual Dose Tapering May Facilitate Flare-free Withdrawal of Glucocorticoids in Patients with Systemic Lupus Erythematosus

    Spyridon Katechis1, Sofia Pitsigavdaki2, Myrto Nikoloudaki2, Panagiotis Garantziotis3, Ettore Silvagni4, Argyro Repa2, Antonio Marangoni5, Irini Flouri6, Nestor Avgoustidis7, Konstantinos Parperis8, Marcello Govoni5, Prodromos Sidiropoulos9, Dimitrios Boumpas10, Antonios Fanouriakis1, George Bertsias2 and Alessandra Bortoluzzi5, 1Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, Attikon University Hospital, Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, Athens, Greece, Athens, Greece, 2Rheumatology and Clinical Immunology, University of Crete School of Medicine, Heraklion, Greece, Heraklion, Greece, 3Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, Erlangen, Germany, 4Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Ferrara, Italy, Ferrara, 5Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria S.Anna, Ferrara, Italy, Ferrara, Italy, 6Rheumatology and Clinical Immunology, University of Crete School of Medicine, Heraklion, Greece, Heraklio, Crete, Greece, 7University Hospital, Rheumatology and Clinical Immunology,, Heraklion, Greece, 8University of Cyprus Medical School, Nicosia, Cyprus, 9University of Crete, Laboratory of Rheumatology, Autoimmunity and Inflammation. University Hospital, Rheumatology, Clinical Immunology. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece, HERAKLIO, Greece, 104th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, Athens, Greece

    Background/Purpose: For patients with SLE who are treated with glucocorticoids (GC), discontinuation of the latter is an important goal. However, the clinical conditions under which…
  • Abstract Number: 2591 • ACR Convergence 2024

    Lupus-Related Reproductive Health Experiences and Needs of Women of Childbearing Age: A Qualitative Study

    Yasmine Shakur1, Charmayne M. Dunlop-Thomas2, S. Sam Lim1 and Subasri Narasimhan1, 1Emory University, Atlanta, GA, 2Emory University School of Medicine, Department of Medicine, Division of Rheumatology, Atlanta, GA

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune condition that primarily affects women of childbearing age, with many patients being diagnosed during puberty. Contraception…
  • Abstract Number: 2678 • ACR Convergence 2024

    History of Cutaneous Lupus Promotes Blood and Skin Interferon Signatures in SLE Patients

    Svenja Henning1, Lam Tsoi2, Craig Dobry2, Celine Berthier2, Benjamin Klein2, Amy Hurst2, Rachael Wasikowski3, Johann Gudjonsson2 and J. Michelle Kahlenberg2, 1University of Groningen, Groningen, Netherlands, 2University of Michigan, Ann Arbor, MI, 3Michigan, Dept. of Dermatology, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus (CLE) can present in isolation or as one of the most common manifestations of systemic lupus erythematosus (SLE). Interferon (IFN) stimulated genes…
  • Abstract Number: 0085 • ACR Convergence 2024

    A Novel, Potent and Selective TLR7/8 Small Molecule Inhibitor Blocks TLR7/8 Pathway in the Presence of HCQ and Demonstrates Robust Preclinical Efficacy in Lupus Models

    Ching Shang1, Angie Hammond2, Yuanjiang Yu1, Bing Xia1, Yew Ann Leong1, Emily Chung1, zhiyu Huang1, Paqui Gonzalez Traves3, Wesley Minto1, Sunish Mohanan1, Hailing Zong1, Gundula Min-oo1, Stephen Ammann4, Eda Canales5 and Natasha Crellin3, 1Gilead Sciences, Foster City, CA, 2Gilead Sciences, Inc., Seattle, WA, 3Gilead, Foster City, CA, 4Gilead Sciences, Foster City, 5Gilead Sciences, San Mateo, CA

    Background/Purpose: Toll-like receptor 7, 8 and 9 (TLR7/8/9) are endosomal nucleic acid sensors that when aberrantly activated, induce Type I interferon (IFNα), proinflammatory cytokines, immune…
  • Abstract Number: 0136 • ACR Convergence 2024

    Demographic and Clinical Characteristics of Patients with SLE Across 5 Registries – the LupusNet Federated Data Network

    Federico Zazzetti1, Urbano Sbarigia2, William Giovanini3, Claire Blacketer4, Michel van Speybroeck5, Teresa A. Simon6, Guo Li3, Chetan S. Karyekar4, Reyhan Sonmez7, Manuel Ugarte-Gil8, RV, Gamboa-Cardenas9, Victor Pimentel-Quiroz10, Guillermo Pons-Estel11, Bernardo Pons-Estel12, Rosana Quintana13, Veronica Saurit14, ODIRLEI MONTICIELO15, Katiuzka Zuñiga Corrales16, Jorge Esquivel-Valerio17, Martin Rebella18, Cecilia Pisoni19, Francinne Machado Ribeiro20, Carlos Núñez-Álvarez21, Kaleb Michaud22, Patricia Katz23, Rangi Kandane-Rathnayake24, Eric Morand25, Worawit Louthrenoo26, Yi-Hsing Chen27, Jiacai Cho28, Laniyati Hamijoyo29, Shue Fen Luo30, Yeong-Jian Jan Wu30, Sandra Navarra31, Sargunan Sockalingam32, Masayoshi Harigai33, Zhuoli Zhang34, BMDB Basnayake35, Madelynn Chan36, Tsutomu Takeuchi37, Sang-Cheol Bae38, Fiona Goldblatt39, Sean O'Neill40, Kristine (Pek Ling) Ng41, Yih Jia Poh42, Nicola Tugnet43, Sunil Kumar44, Michael Tee45, Yoshiya Tanaka46 and Chak Sing. Lau47, Alberta Hoi48, Mandana Nikpour49, Mark Sapsford50, Íñigo Rúa-Figueroa50, José María Pego-Reigosa51, María Galindo-Izquierdo52, Jaime Calvo-Alén53, Antonio Fernández-Nebro54, Raúl Menor Almagro55 and Frederic Lavie56, 1Johnson & Johnson Innovative Medicine, Horsham, PA, PA, 2Johnson & Johnson Innovative Medicine, Brussels, Belgium, 3The Janssen Pharmaceutical Companies of Johnson & Johnson, Titusville, NJ, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Pharmaceutica, Beerse, Belgium, 6Physicians Research Center, LLC, Toms River, NJ, 7EFOR-CVO Life Sciences Consultancy, Basel, Switzerland, 8Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas. Universidad Científica del Sur. Lima. Perú Servicio de Reumatología. Hospital Guillermo Almenara Irigoyen-EsSalud, Lima, Peru, 9Universidad Científica del Sur, Lima, Lima, Peru, 10Universidad Científica del Sur/Hospital Nacional Guillermo Almenara Irigoyen, Magdalena del Mar, Peru, 11Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, ROSARIO, Santa Fe, Argentina, 12Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Santa Fe, Argentina, 13Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, 14hospital privado universitario de cordoba, Córdoba, Argentina, 15HOSPITAL DE CLINICAS DE PORTO ALEGRE, PORTO ALEGRE, Rio Grande do Sul, Brazil, 16Hospital Cayetano Heredia. Universidad Peruana Cayetano Heredia, Lima, Peru, 17Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, MONTERREY, Mexico, 18Unidad Enfermedades Autoinmunes Sistemicas, Clinica Medica C-Hospital de Clinicas, UDELAR Montevideo, Montevideo, Uruguay, 19CEMIC, Buenos Aires, Argentina, 20Hospital Universitario Pedro Ernesto, UERJ, Rio De Janeiro, Brazil, Rio de Janeiro, Brazil, 21Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico, Mexico, Mexico, 22University of Nebraska Medical Center, Omaha, NE, 23University of California San Francisco, San Francisco, CA, 24Monash University, Clayton, Victoria, Australia, 25School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia, 26Chiang Mai University, Chang Wat Chiang Mai, Thailand, 27Taichung Veterans General Hospital, Taichung, Taiwan (Republic of China), 28National University Hospital, Kent Ridge, Singapore, 29University of Padjadjaran, Sumedang Regency and Bandung, Indonesia, 30Chang Gung Memorial Hospital, Taoyuan City, Taiwan (Republic of China), 31University of Santo Tomas, Manila, Philippines, 32University of Malaya Medical Centre, Kuala Lumpur, Malaysia, 33Tokyo Women's Medical University, Tokyo, Japan, 34Peking University First Hospital, Beijing, China, 35Teaching Hospital, Kandy, Sri Lanka, 36Tan Tock Seng Hospital, Singapore, Singapore, 37Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 38Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 39Flinders Medical Centre, Adelaide, Australia, 40Liverpool Hospital; Royal North Shore Hospital; University of New South Wales and the University of Sydney, Sydney, New South Wales, Australia, 41Health New Zealand Waitemata, Te Whatu Ora (North Shore Hospital), Auckland, New Zealand, 42SingHealth, Singapore, Singapore, 43Auckland District Health Board, Auckland, New Zealand, 44Health New Zealand Counties Manukau, Te Whatu Ora (Middlemore Hospital), Auckland, New Zealand, 45University of the Philippines, Manila, Philippines, 46Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 47University of Hong Kong, Pok Fu Lam, Hong Kong, 48Monash Health, Monash University, Melbourne, AU, Melbourne, Victoria, Australia, 49The University of Sydney, Melbourne, Victoria, Australia, 50Middlemore Hospital, Auckland, New Zealand, 50Department of Rheumatology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas GC, Spain, 6Galicia Health Service (SERGAS), Vigo, Spain, 52Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 53Department of Rheumatology, Hospital Araba, Vitoria, Pais Vasco, Spain, 54Department of Rheumatology, Hospital Universitario de Málaga, Málaga, Andalucia, Spain, 55Department of Rheumatology, Hospital Jerez de la Frontera, Jerez de la Frontera, Spain, 56Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with a broad range of clinical manifestations and a high unmet need across patient populations. Real-world…
  • Abstract Number: 0185 • ACR Convergence 2024

    New and Severe Damage in a Prevalent Lupus Cohort Through the Lens of Demographic and Neighborhood Disparities

    Jonathan Katz1, Ang Yu2, Felix Elwert2, Robert Greenlee3, David Gazeley4, Ann Rosenthal5, Jenna Cormier5, Bryn Sutherland5, Shalvi Parikh6, Yiran Jiang7 and Christie Bartels8, 1University of Wisconsin Hospitals and Clinics, Madison, WI, 2University of Wisconsin-Madison, Madison, WI, 3Marshfield Clinical Research Institute, Marshfield, WI, 4Medical College of Wisconsin, Wauwatosa, WI, 5Medical College of Wisconsin, Milwaukee, WI, 6Mississippi Delta Family Medicine Residency, Greenville, MS, 7Annapolis Rheumatology, Washington, DC, 8University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Systemic Lupus Erythematosus (SLE) disproportionally affects minoritized populations.  SLE damage, assessed by SLICC/ACR Damage Index (SDI), is higher in Black than in White US…
  • Abstract Number: 0247 • ACR Convergence 2024

    Enhanced Immunogenicity of the Recombinant Herpes Zoster Vaccine After One-Week of Mycophenolate Mofetil Discontinuation in Patients with Autoimmune Rheumatic Diseases: Interim Results from a Prospective Randomized Phase 4 Study

    Sandra Pasoto1, Isabele Antonelli1, Ana Cristina Medeiros-Ribeiro2, Nadia Aikawa3, Leonard Kupa1, Eduardo Borba1, Luciana Seguro4, Emily Figueiredo Neves Yuki1, ANA PAULA ASSAD1, Carla Saad4, Andrea Shimabuco4, Andrea Negrini1, Julia Medeiros1, Talita Ribeiro1, Samuel Shinjo4, Percival Sampaio-Barros4, Danieli Andrade5, Fernando Souza4, Renata Miossi4, Clovis Silva6 and Eloisa Bonfa1, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Jose Dos Campos, Brazil, 3Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil, 5University of São Paulo, São Paulo, SP, Brazil, 6Rheumatology Division and Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil

    Background/Purpose: Recently, it was demonstrated that temporarily halting mycophenolate mofetil (MMF) for 1-week post-COVID-19 vaccination in systemic lupus erythematosus (SLE) patients improved humoral response, without…
  • Abstract Number: 0437 • ACR Convergence 2024

    Describing Maternal Outcomes Among Veterans with a History of Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Deirdre Quinn1, Florentina Sileanu1, Gregory Procario1, Shannon Mitchell1 and Mehret Birru Talabi2, 1VA Pittsburgh Healthcare System, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Veterans who utilize Department of Veterans Affairs (VA) maternity benefits, nearly half (42%) of whom represent racial or ethnic minority groups, have a high…
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