Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2449 • ACR Convergence 2025
Patient Characteristics, Treatment and Prognosis in Patients with Neuromyelitis OpticaSpectrum Disorder Coexisting with Systemic Lupus Erythematosus or Sjögren’s Syndrome: An Analysis Using Japanese Inpatient Database
Hiroshi Shiba¹, Mikio Nakajima², Kaito Nakamura³, Yusuke Sasabuchi⁴, Hiroyuki Ohbe⁵, Yuya Kimura⁶, Tadahiro Goto⁷, Hiroki Matsui⁸, Kiyohide Fushimi⁹ and Hideo Yasunaga⁵, ¹Suwa central hospital, Chino, Japan, ²Emergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Hiroo, Tokyo, Japan, ³Department of Rheumatology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan, ⁴Department of Real-world Evidence, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, ⁵Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, ⁶Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan, ⁷Department of Health Data Science, Graduate School of Data Science, Yokohama City University, Yokohama, Kanagawa, Japan, ⁸Department of Clinical Epidemiology and Health Economics, School of Public Health, Bunkyo-ku, Tokyo, Japan, ⁹Department of Health Policy and Informatics, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan
Background/Purpose: Neuromyelitis optica spectrum disorder (NMOSD) can coexist with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Due to overlapping clinical presentations and the rarity…
Abstract Number: 2432 • ACR Convergence 2025
Duffy Null Genotype and Autoantibodies Synergistically Contribute to Severe Leukopenia in Systemic Lupus Erythematosus
valerie Lewis¹, Faith Porter², Victoria Nwankwo³, John Ice⁴, Joshua Cavett⁵ and R Hal Scofield¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Langston University, Langton, OK, ³Emory University, Atlanta, GA, ⁴OKC VA Healthcare System, Oklahoma City, OK, ⁵Oklahoma Medicar Research Foundtion, Oklahoma City
Background/Purpose: Systemic lupus erythematosus (SLE) is a common, complex inflammatory autoimmune disease in which dysregulation of both innate and adaptive immune responses has been implicated…
Abstract Number: 2413 • ACR Convergence 2025
Hydroxychloroquine and Adverse Cardiovascular Outcomes in Pregnant Patients with Systemic Lupus Erythematosus
Mariana Gonzalez-Treviño¹, Ashley L Ciosek¹, Genessis Maldonado¹, Catherine Deffendall², Tania Ruiz¹, Tracy Frech¹ and Rashmi Dhital³, ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University, Nashville, TN, ³Vanderbilt University Medical Center, Brentwood, TN
Background/Purpose: Hydroxychloroquine (HCQ) is a medication used in SLE during pregnancy. An adverse effect of HCQ includes cardiotoxicity. Hormonal changes during pregnancy may trigger SLE…
Abstract Number: 2395 • ACR Convergence 2025
Analysis of histopathological changes in the placenta of patients with systemic lupus erythematosus
Bartira Melo¹, Elizabeth Avvad², Marcela lacerda², Nilson jesus², Evandro Klumb² and Guilherme Ramires de Jesus³, ¹UERJ- Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²UERJ - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ³Universidade do Estado do Rio de Janeiro, Rio De Janeiro, Rio de Janeiro, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is more frequent in women of reproductive age and pregnancy in these patients is considered as high risk. The inflammatory…
Abstract Number: 2379 • ACR Convergence 2025
Predicting Type 1 and Type 2 SLE Activity Using the LupusPRO
Amanda Eudy¹, Megan Clowse², Meenakshi Jolly³, Dana Burshell⁴, David Pisetsky⁵, Connor Drake⁴, Tamara Somers⁶, Ralph Snyderman⁷, Kai Sun⁸, Rebecca Sadun⁸, Lisa Criscione-Schreiber⁴, Mithu Maheswaranathan⁴, Nathaniel Harris⁵, Jayanth Doss⁹ and Jennifer Rogers⁴, ¹Duke University, Raleigh, NC, ²Duke University, Chapel Hill, NC, ³Rush University, Chicago, ⁴Duke University School of Medicine, Durham, ⁵Duke University Medical Center, Durham, NC, ⁶Duke University School of Medicine, Durham, NC, ⁷Duke Center for Personalized Health Care, Durham, NC, ⁸Duke University, Durham, NC, ⁹Division of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC
Background/Purpose: The Type 1 & 2 SLE Model separates lupus disease activity into two groups: Type 1 (e.g. arthritis, rash, nephritis) and Type 2 SLE…
Abstract Number: 2202 • ACR Convergence 2025
Epidemiologic Evaluation of Postpartum Mental Health for Women Living with Systemic Lupus Erythematosus: A Population-Based Cohort Study Among Medicaid Enrollees
Alyssa Howren¹, Amadeia Rector², Sadaf Sediqi³ and Julia F Simard⁴, ¹Stanford University, Menlo Park, CA, ²Stanford University, San Francisco, CA, ³Stanford University, Palo Alto, CA, ⁴Stanford Medicine, Stanford, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease, predominately affecting women during their reproductive years. Despite widespread evidence that individuals with SLE…
Abstract Number: 1919 • ACR Convergence 2025
Financial insecurity and discrimination are associated with patient-reported quality of life in patients with SLE
Heather Gold¹, Yi Li¹, Peter Izmirly², Jill Buyon¹, Mala Masson³, Amit Saxena¹, H Michael Belmont⁴, Chung-E Tseng⁵ and Rebecca Anthopolos¹, ¹NYU Grossman School of Medicine, New York, NY, ²New York University Grossman School of Medicine, New York, NY, ³NYU Langone Health, New York, ⁴NYU School of Medicine, New York, NY, ⁵New York University Grossman School of Medicine, Flushing, NY
Background/Purpose: Manifestations of SLE are known to affect patient-reported outcome measures (PROs) such as physical function, fatigue, and pain. Other work has suggested economic insecurity…
Abstract Number: 1849 • ACR Convergence 2025
Time-course RNA sequencing analysis of longitudinal peripheral blood samples to elucidate the factors determining treatment resistance in systemic lupus erythematosus
Shuji Sumitomo¹, Hideki Oka², Takeshi Iwasaki³ and Koichiro Ohmura⁴, ¹Kobe City Medical Center General Hospital, Kobe city, Hyogo, Japan, ²Kobe City Medical Center General Hospital, Kobe, Japan, ³Kyoto University, Kyoto, Japan, ⁴Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) encompasses a subset of patients who exhibit resistance to standard treatments, posing a significant challenge to achieving remission. Our study…
Abstract Number: 1818 • ACR Convergence 2025
Epigenetic Profiling of Childhood-onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity
Desire Casares Marfil¹, Gülşah Kavrul Kayaalp², Vafa Guliyeva², Özlem Akgün², Şeyma Türkmen³, Elif Kilic Konte⁴, Seher Şener⁵, Sezgin Sahin⁴, Ozgur Kasapcopur⁶, Betul Sozeri⁷, Selçuk Sözer Tokdemir⁸, Seza Özen⁹, Nuray Aktay Ayaz² and Amr Sawalha¹, ¹University of Pittsburgh, Pittsburgh, PA, ²Istanbul University Faculty of Medicine, Istanbul, Turkey, ³University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey, ⁴Istanbul University Cerrahpasa Medical School, Istanbul, Turkey, ⁵Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁶Istanbul University-Cerrahpasa, Cerrahpasa Medical School, istanbul, Turkey, ⁷Health sciences university, Istanbul, Turkey, ⁸Istanbul University, Istanbul, Turkey, ⁹Hacettepe University Medical Faculty, Ankara, Turkey
Background/Purpose: Childhood-onset lupus is generally associated with a more severe disease course than adult-onset lupus. DNA methylation alterations are known to play a key role…
Abstract Number: 1718 • ACR Convergence 2025
Mortality and Hematological Adverse Events in Patients with Cancer Receiving Immune Checkpoint Inhibitors: Impact of Pre-existing Systemic Lupus Erythematosus
Kevin Sheng-Kai Ma¹, Dominique Feterman Jimenez², You Wu³, Jenna Thomason³, Jean Liew⁴ and Namrata Singh⁵, ¹Center for Global Health, Perelman School of Medicine, Philadelphia, PA, ²University of Washington, Seattle, ³University of Washington, Seattle, WA, ⁴Boston University, Boston, MA, ⁵University of Washington, Bellevue, WA
Background/Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but their safety profile in patients with pre-existing autoimmune diseases, such as systemic lupus erythematosus (SLE),…
Abstract Number: 1638 • ACR Convergence 2025
Comparison and Assessment of the All of Us Dataset for Epidemiologic Studies of Systemic Lupus Erythematosus (SLE) Among African American Women
Katherine Singleton¹, Sarah Smith², Charmayne Dunlop-Thomas³, L. Quinnette King², Lori Ann Ueberroth⁴, Edith Williams⁵, S. Sam Lim⁶, Bethany Wolf², Diane Kamen⁷ and Paula Ramos⁶, ¹Emory University School of Medicine, Atlants, GA, ²Medical University of South Carolina, Charleston, SC, ³Emory University, Atlanta, GA, ⁴Medical University of South Carolina, Charleston, ⁵University of Rochester Medical Center, Rochester, NY, ⁶Emory University School of Medicine, Atlanta, GA, ⁷Medical University of South Carolina, Johns Island, SC
Background/Purpose: Health disparities in SLE are well established, with African American women being disproportionately impacted. Despite the known associations between sociodemographic and genetic factors with…
Abstract Number: 1540 • ACR Convergence 2025
Association of Hypoalbuminemia with Serious Infections in Systemic Lupus Erythematosus Patients Receiving Dialysis
Ping Hsuan Kuo¹, Pu Jun Fang², Chien-Chih Lai³ and Yi-Syuan Sun⁴, ¹Taipei Veteran General Hospital, Taipei City, Taiwan (Republic of China), ²Tri-Service General Hospital, Hukou Township, Taiwan (Republic of China), ³Taipei Veterans General Hospital, Taipei City, Taiwan (Republic of China), ⁴taipei VGHTPE, ???, Taiwan (Republic of China)
Background/Purpose: Lupus nephritis, a key manifestation of systemic lupus erythematosus (SLE), can progress to end-stage kidney disease and increase patient burden. While patients with SLE…
Abstract Number: 1520 • ACR Convergence 2025
Long-Term Effects of Obinutuzumab on Kidney Function in Lupus Nephritis
Bahtiyar Toz¹, Himanshu Vashistha² and Richard Furie³, ¹Zucker School of Medicine at Hofstra/ Northwell, Queens, NY, ²Northwell Health, Great Neck, NY, ³Division of Rheumatology, Northwell Health, Great Neck, NY
Background/Purpose: Biologic treatments for lupus nephritis (LN) have improved short-term outcomes. Obinutuzumab (OBI), an anti-CD20 monoclonal antibody, demonstrated efficacy in the NOBILITY and REGENCY trials;…
Abstract Number: 1497 • ACR Convergence 2025
Acute Care Utilization in Patients with Antiphospholipid Syndrome and/or Systemic Lupus Erythematosus
Megan Barber¹, Fengjuan Yang², Leslie Skeith², Danielle Southern³ and Ann Clarke¹, ¹Division of Rheumatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³University of Calgary, Calgary, Canada
Background/Purpose: Little is known about acute care utilization in patients with APS and/or SLE. This study focuses on hospitalizations, intensive care unit (ICU) admissions and…
Abstract Number: 1482 • ACR Convergence 2025
Evaluation of T Cell Subpopulations, CD4/CD8 Ratio and p16INK4a in Patients with Systemic Lupus Erythematosus and Cognitive Impairment
Erik Cimé-Aké¹, Guadalupe Lima¹, Emilio Godinez-Lazarini¹, Sandra Juárez¹, Hilda Marín-López¹, Amairani Gómez-Rodríguez¹, Daniela Flores-Hernández¹, Ileana Flores-Hernández¹, Diego F. Hernández-Ramírez¹, Luis Llorente¹ and Hilda Fragoso-Loyo², ¹Instituto Nacional de Ciencias Médicas y Nutrición. Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, ²Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Mexico
Background/Purpose: Cognitive impairment (CI) in systemic lupus erythematosus (SLE) may be associated with different T cell subpopulations distribution and chronic pro-inflammatory state in which immunosenescence…

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