Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2683 • 2012 ACR/ARHP Annual Meeting
Interferon-Associated Cytokine and Chemokine Expression in Patients with Serologically Active Clinically Quiescent (SACQ) Systemic Lupus Erythematosus (SLE)
Amanda J. Steiman¹, Murray B. Urowitz², Dominique Ibanez², Carolina Landolt-Marticorena³, Dafna D. Gladman⁴ and Joan E. Wither⁵, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Interferon-α (IFN-α) plays a prominent pro-inflammatory role in SLE. Studies suggest clinical/serologic discordance may illuminate SLE pathophysiology: peripheral IFN-α production is blunted in autoantibody-producing,…
Abstract Number: 2260 • 2012 ACR/ARHP Annual Meeting
Serum DNAse I Anti DNAse I Antibodies , CRP and Antibodies to CRP Relation to Disease Activity in Systemic Lupus Eryhtematous: Longitudinal Studies
Ramnath Misra¹, Avadesh Pratap², Amit Singh¹ and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunlogy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Technician, Lucknow, India
Background/Purpose: Defective clearance of both nuclesomes and immune complexes has been suggested to intiate and perpetuate the disease. Defects in DNAse I gene in mice have shown SLE like symptoms,…
Abstract Number: 942 • 2012 ACR/ARHP Annual Meeting
Validity and Reliability of the Lupus Damage Index Questionnaire (LDIQ): A Prospective Study
Yuko Okamoto, Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka, Yuko Ota and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI) is a validated instrument for assessing organ damage in systemic lupus…
Abstract Number: 1897 • 2012 ACR/ARHP Annual Meeting
Pregnancy and Contraception in Adolescents and Teens with SLE: Are pediatric rheumatologists adequately Screening and Educating Their Patients?
Deirdre I. De Ranieri¹, Karen Onel², Linda Wagner-Weiner¹ and Melissa S. Tesher³, ¹Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, ²Pediatric Rheumatology, University of Chicago, Chicago, IL, ³Pediatric Rheum/MC 5044, University of Chicago, Chicago, IL
Background/Purpose: Pregnancy in patients with systemic lupus erythematosus (SLE) is often complicated by both disease flares and risks to the fetus. It is important that young women with SLE be educated on both the…
Abstract Number: 943 • 2012 ACR/ARHP Annual Meeting
Impact of Systemic Lupus Erythematosus On Work Productivity and Income in the United States
Alan Oglesby¹, Ellen Sulcs², Siva Narayanan³, Mechele Lee² and Cindy Garris⁴, ¹GlaxoSmithKline, Research Triangle Park, NC, ²Healthcare Research, Harris Interactive Inc., Rochester, NY, ³Global Health Economics and Outcomes Research and Epidemiology, Human Genome Sciences, Inc., Rockville, MD, ⁴US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disorder characterized by fluctuating periods of disease activity affecting multiple organ systems. This study was…
Abstract Number: 1795 • 2012 ACR/ARHP Annual Meeting
Correction for Basophil and Monocyte Frequencies Identifies Specific Gene Expression Differences Associated with SLE Disease Flare: Interim Report From the Bold (Biomarkers of Lupus Disease) Study
Mikhail G. Dozmorov¹, Nicolas Dominguez², Stan Kamp³, Cory Giles², Jonathan D. Wren⁴, Sudhakar T. Sridharan⁵, Joan T. Merrill³, Judith A. James⁶ and Joel M. Guthridge², ¹Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵BioTherapeutics R&D, Pfizer Inc, Collegeville, PA, ⁶Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Heterogeneity of clinical manifestations and pathogenic mechanisms has complicated treatment of SLE patients. The BOLD study allows evaluation of gene expression changes associated with…
Abstract Number: 944 • 2012 ACR/ARHP Annual Meeting
Job-Related Burden and Effort-Reward Imbalance in Patients with Systemic Lupus Erythematosus
Jutta G. Richter¹, Thomas Muth², Ralph Brinks¹, Tobias Koch³, Johannes Siegrist⁴, Nicole Hoffmann¹, Peter Angerer² and Matthias Schneider¹, ¹Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ²Institute for Occupational and Social Medicine, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ³Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ⁴Department of Medical Sociology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: Working life factors influence patients’ (life) satisfaction and well being. Effort at work is part of a social contract that reciprocates effort by adequate…
Abstract Number: 1710 • 2012 ACR/ARHP Annual Meeting
Increase in Vitamin D Improves Disease Activity and Systolic Blood Pressure in Systemic Lupus Erythematosus
Kayode J. Bello¹, Hong Fang², Laurence S. Magder³ and Michelle Petri², ¹Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD
Background/Purpose: Vitamin D deficiency has also been associated with different chronic conditions including cardiovascular diseases such as coronary artery disease, cardiac failure and hypertension. In…
Abstract Number: 932 • 2012 ACR/ARHP Annual Meeting
Medical Costs and Health Care Resource Use in Patients with Systemic Lupus Erythematosus in an Insured Population
Daniel Furst¹, Ann E. Clarke², Ancilla W. Fernandes³, Tim Bancroft⁴, Kavita Gajria³, Warren Greth⁵ and Serban R. Iorga⁴, ¹Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ²McGill University, Montreal, QC, Canada, ³MedImmune LLC, Gaithersburg, MD, ⁴OptumInsight, Eden Prairie, MN, ⁵Clinical Development, MedImmune, LLC, Gaithersburg, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may affect multiple organ systems. The clinical manifestations of SLE are heterogeneous, and subjects…
Abstract Number: 1427 • 2012 ACR/ARHP Annual Meeting
Late Onset Systemic Lupus Erythematosus: Is It Actually A Milder Variant?
Juan G. Ovalles-Bonilla¹, Julia Martínez-Barrio¹, Javier Lopez-Longo¹, Inmaculada de la Torre¹, Carlos Gonzalez Fernandez¹, María Montoro Álvarez¹, Francisco Aramburu¹, Carolina Marin¹, Lina Martinez-Estupiñan¹, Juan C. Nieto², Michelle Hinojosa¹, Natalia Bello¹, Indalecio Monteagudo¹ and Luis Carreño¹, ¹Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ²Pediatria II, Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: Classically, late onset Systemic Lupus Erythematosus (SLE) has been described as a milder variant of the disease. The objective of this study is to…
Abstract Number: 886 • 2012 ACR/ARHP Annual Meeting
Association Between Neutrophil Gene Signature and Disease Characteristics in Systemic Lupus Erythematosus Patients
Michelle Petri¹, Hong Fang¹, Jadwiga Bienkowska², Norm Allaire³, Jeff Browning⁴ and Susan Kalled³, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Translational Medicine, Biogen Idec Inc., Cambridge, MA, ³Biogen Idec Inc., Cambridge, MA, ⁴Boston University School of Medicine, Boston, MA
Background/Purpose: Neutrophils and neutrophil death (“netosis”) are now understood to play a role in the pathogenesis of SLE. A neutrophil gene signature exists in SLE,…
Abstract Number: 1412 • 2012 ACR/ARHP Annual Meeting
Vascular Cell Adhesion Molecule (VCAM-1) and Angiostatin in Systemic Lupus Erythematosus
Adnan Kiani¹, Hong Fang¹, Tianfu Wu², Chandra Mohan³ and Michelle Petri¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ³Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Vascular cell adhesion molecule-1 (VCAM-1), an adhesion molecule, is involved in the progression of glomerular and tubulointerstitial injury. High levels of VCAM-1 have been…
Abstract Number: 843 • 2012 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 5 Associates with Systemic Lupus Erythematosus Through Two Distinct and Independent Effects
Erin Zoller¹, Leah C. Kottyan², Bahram Namjou¹, Samuel Vaughn¹, Miranda C. Marion³, Carl D. Langefeld⁴, Marta E. Alarcon-Riquelme⁵, Juan-Manuel Anaya⁶, Elizabeth E. Brown on behalf of PROFILE⁷, Sang-Cheol Bae⁸, Jeffrey C. Edberg⁹, Patrick M. Gaffney¹⁰, Diane L. Kamen¹¹, Robert P. Kimberly¹², Chaim O. Jacob¹³, Joan T. Merrill¹⁴, Kathy Moser Sivils¹⁵, Michelle Petri¹⁶, Rosalind Ramsey-Goldman¹⁷, John D. Reveille¹⁸, Anne M. Stevens¹⁹, Betty P. Tsao²⁰, Luis M. Vila²¹, Timothy J. Vyse²² and Kenneth M. Kaufman²³, ¹Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ⁴Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁵Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, ⁶School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, ¹²Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹³Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ¹⁴Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁷Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁸Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ¹⁹Pediatrics, University of Washington, Seattle, WA, ²⁰Medicine/Rheumatology, UCLA School of Medicine, Los Angeles, CA, ²¹Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ²²Medical & Molecular Genetics, King's College London, London, United Kingdom, ²³1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH
Background/Purpose: Powerful evidence suggests that Systemic lupus erythematous (SLE or lupus) autoimmunity is mediated by disregulation of the IRF5-NFκB signaling pathway. The interferon regulatory factor 5…
Abstract Number: 1387 • 2012 ACR/ARHP Annual Meeting
Hospitalizations and Reasons for Admission in a Clinical SLE Cohort
Alaa Dekis¹, Kenjey Chan¹, Christian A. Pineau², Evelyne Vinet³, Emil P. Nashi², Sasha Bernatsky⁴ and Ann E. Clarke⁴, ¹Clinical Epidemiology, McGill University, Montreal, QC, Canada, ²Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ³McGill University Health Center, Montreal, QC, Canada, ⁴Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Data published from several countries have suggested that patients affected by systemic lupus erythematous (SLE) may have high annual hospitalization rates. However, there is…
Abstract Number: 845 • 2012 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Immune Complexes Upregulate the Expression of CD319 and CD229 On Plasmacytoid Dendritic Cells
Niklas Hagberg¹, Jakob Theorell², Gunnar V. Alm³, Maija-Leena Eloranta⁴, Yenan Bryceson² and Lars Rönnblom⁴, ¹Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden, ⁴Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
Background/Purpose: Patients with SLE have an activated type I interferon (IFN) system due to an ongoing IFN-alpha synthesis by plasmacytoid dendritic cells (pDCs) stimulated by…

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