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Abstracts tagged "systemic lupus erythematosus (SLE) and vitamins"

  • Abstract Number: 691 • 2012 ACR/ARHP Annual Meeting

    Characterization of Pro-Inflammatory Cytokines and Vitamin D Levels in a Lupus Cohort and Correlation with Disease Activity

    Rohan Willis1, Praveen Jajoria1, Brock E. Harper2, Emilio B. Gonzalez3, Michelle Petri4, Ehtisham Akhter5, Hong Fang4 and Silvia S. Pierangeli1, 1Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 2Int Med/Rheumatology, University of Texas Medical Branch, Galveston, TX, 3Rheumatolgoy/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 4Johns Hopkins University School of Medicine, Baltimore, MD, 5Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Multiple cytokines play a role in the immune dysregulation seen in systemic lupus erythematosus (SLE) and the local inflammatory responses that ultimately lead to…
  • Abstract Number: 2619 • 2012 ACR/ARHP Annual Meeting

    A Double-Blind Randomized Placebo-Controlled Trial of the Effect of Vitamin D3 On the Interferon Signature in Patients with Systemic Lupus Erythematosus

    Cynthia Aranow1, Maria Dall'era2, Elena M. Massarotti3, Meggan C. Mackay4, Andreea Coca5, Fotios Koumpouras6, Marc C. Levesque7, W. Winn Chatham8, Megan E. B. Clowse9, Lisa G. Criscione-Schreiber10, Sherri Callahan11, Ellen A. Goldmuntz12, Lynette Keyes-Elstein13, Betty Diamond14 and Diane L. Kamen15, 1Feinstein Institute for Medical Research, Manhasset, NY, 2Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 3Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4Autoimmune & Musculoskeletal Disease, The Feinstein Institute, Manhasset, NY, 5Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 6Lupus Center of Excellence, West Penn Hospital, Pittsburgh, PA, 7Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 8University of Alabama at Birmingham, Birmingham, AL, 9Rheumatology, Duke University Medical Center, Durham, NC, 10Rheumatology, Duke University Health System, Durham, NC, 11Dait, NIAID/NIH Rm 6807, Bethesda, MD, 12DAIT, NIAID/NIH, Bethesda, MD, 13Rho Federal Systems, Inc., Chapel Hill, NC, 14Autoimmune & Musculoskeletal, Feinstein Institute Med Rsch, Manhasset, NY, 15Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC

    Background/Purpose: Exposure of normal PBMCs to1,25 OH vitamin D reverses the stimulatory effects of activating SLE sera on the interferon signature.  Given that IFN is…
  • Abstract Number: 2687 • 2012 ACR/ARHP Annual Meeting

    Modular Microarray Analysis Fails to Reveal a Significant Biological Effect of Vitamin D3 Treatment in Patients Participating in a Double-Blind Randomized Placebo-Controlled Trial of the Effect of Vitamin D3 On the Interferon Signature in Patients with Systemic Lupus Erythematosus

    Michaela Oswald1, Cynthia Aranow2, Diane L. Kamen3, Meggan C. Mackay4, Ellen A. Goldmuntz5, Betty Diamond6, Peter K. Gregersen7 and ALE02 Study Team8, 1Laboratory of Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, 2Feinstein Institute for Medical Research, Manhasset, NY, 3Department of Medicine, Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Charleston, SC, 4Autoimmune & Musculoskeletal Disease, The Feinstein Institute, Manhasset, NY, 5DAIT, NIAID/NIH, Bethesda, MD, 6Autoimmune & Musculoskeletal, Feinstein Institute Med Rsch, Manhasset, NY, 7Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 8NIAID/NIH Rm 6807, Bethesda, MD

    Background/Purpose: Vitamin D modulates the immune response. Exposing normal PBMCs to activating SLE sera induces an interferon signature which can be inhibited by preexposure of…
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