Abstracts tagged "systemic lupus erythematosus (SLE) and transforming growth factor"

Abstract Number: 1091 • 2016 ACR/ARHP Annual Meeting
Synergistic Immunoregulatory Effects of IL-10 and TGF-β on Humoral Immunity
Toshihiko Komai¹, Tomohisa Okamura^1,2, Mariko Inoue¹, Yukiko Iwasaki¹, Kaoru Morita¹, Kazuhiko Yamamoto¹ and Keishi Fujio¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Max Planck-The University of Tokyo Center for Integrative Inflammology, The University of Tokyo, Tokyo, Japan
Background/Purpose: We have previously identified CD4+CD25-Foxp3- regulatory T cells (Treg) that characteristically express lymphocyte-activation gene 3 (LAG3) produce IL-10. Recently we reported that these Treg…
Abstract Number: 880 • 2012 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 8 Regulates BAFF Production in Murine Macrophages and Is a Nexus for Cross Talk Between IFN-γ and TGF-β
Weijia Yuan¹, Sanjay Gupta², Jane E. Salmon³ and Alessandra B. Pernis², ¹Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ²Autoimmunity & Inflammation, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ³Dept of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Lupus is a systemic autoimmune disease that can lead to severe end-organ damage characterized by unabated inflammation and aberrant tissue repair. Macrophage dysregulation plays…

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