Abstracts tagged "systemic lupus erythematosus (SLE) and toll-like receptors"

Abstract Number: 1613 • 2013 ACR/ARHP Annual Meeting
Anti-Malarial Drugs (hydroxychloroquine and quinacrine) Decrease The Production Of Interferon-Alfa Initiated By TLR-9 Agonist
Ou Jin¹, Xi Zhang¹, Qiuxia Li¹, Lingkai Fang¹, Hongyue Huang¹, Chengcheng Hou¹, Zetao Liao¹, Qiujing Wei¹, Zhiming Lin², Dongfang Lin¹ and Jieruo Gu³, ¹Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine, Third Affiliated Hospital of Sun Yat-sen University, GuangZhou, China
Background/Purpose: Toll-like receptor 9 (TLR-9) plays an important role in initiating innate immunity. The recognition of self DNA fragments by TLR-9 may results in the…
Abstract Number: 1614 • 2013 ACR/ARHP Annual Meeting
Hydroxychloroquine Reverse The Elevation Of Interferon-Alfa Initiated By TLR-9 Agonist Which Irresponsive To Glucocorticoid
Ou Jin¹, Xi Zhang¹, Lingkai Fang¹, Qiuxia Li¹, Hongyue Huang¹, Zhiming Lin², Zetao Liao¹, Dongfang Lin¹, Chengcheng Hou¹ and Jieruo Gu³, ¹Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine, Third Affiliated Hospital of Sun Yat-sen University, GuangZhou, China
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by chronic stimulation of the innate immune system by endogenous nucleic acids through toll-like receptors (TLRs) pathway, which…
Abstract Number: 1617 • 2013 ACR/ARHP Annual Meeting
Toll-Like Receptor 3 Plays a Role In Loss Of Tolerance To The Ro/SSA Auto-Antigen In Systemic Lupus Erythematosus
Julie Ducreux¹, Christine Galant², Julie Verbeeck², Pierre Coulie³, Benoît Van den Eynde³, Frédéric A. Houssiau¹ and Bernard Lauwerys², ¹Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Institut de Duve, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Toll-like Receptor (TLR)7 and TLR9 play a role in the pathogenesis of systemic lupus erythematosus (SLE) by inducing Interferon (IFN)-α and IFN-induced genes expression.…
Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Nicholas A. Young¹, Lai-Chu Wu¹, Craig Burd², Alexandra Friedman¹, Benjamin Kaffenberger¹, Murugesan Rajaram³, Larry S. Schlesinger⁴, Hayley James⁵, Margaret Shupnik⁶ and Wael N. Jarjour⁷, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Center for Microbial Interface Biology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Asthma, Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, VA, ⁶Endocrinology; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…
Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Nicholas A. Young¹, Giancarlo R. Valiente², Lai-Chu Wu¹, Michael Bruss³, Craig Burd⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ³Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…

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