Abstracts tagged "systemic lupus erythematosus (SLE) and toll-like receptors"

Abstract Number: 638 • 2013 ACR/ARHP Annual Meeting
Estrogen-Induced STAT1 and STAT4 Expression Is Estrogen Receptor α Dependent and IFNα Independent: A Novel Mechanism For Sex-Bias In Systemic Lupus Erythematosus Pathogenesis?
Nicholas A. Young¹, Giancarlo R. Valiente², Lai-Chu Wu¹, Michael Bruss³, Craig Burd⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ³Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a devastating multi-organ autoimmune disease displaying an overwhelming female predilection. Estrogen (E2) influences gene expression by binding to estrogen…
Abstract Number: 1613 • 2013 ACR/ARHP Annual Meeting
Anti-Malarial Drugs (hydroxychloroquine and quinacrine) Decrease The Production Of Interferon-Alfa Initiated By TLR-9 Agonist
Ou Jin¹, Xi Zhang¹, Qiuxia Li¹, Lingkai Fang¹, Hongyue Huang¹, Chengcheng Hou¹, Zetao Liao¹, Qiujing Wei¹, Zhiming Lin², Dongfang Lin¹ and Jieruo Gu³, ¹Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine, Third Affiliated Hospital of Sun Yat-sen University, GuangZhou, China
Background/Purpose: Toll-like receptor 9 (TLR-9) plays an important role in initiating innate immunity. The recognition of self DNA fragments by TLR-9 may results in the…
Abstract Number: 1614 • 2013 ACR/ARHP Annual Meeting
Hydroxychloroquine Reverse The Elevation Of Interferon-Alfa Initiated By TLR-9 Agonist Which Irresponsive To Glucocorticoid
Ou Jin¹, Xi Zhang¹, Lingkai Fang¹, Qiuxia Li¹, Hongyue Huang¹, Zhiming Lin², Zetao Liao¹, Dongfang Lin¹, Chengcheng Hou¹ and Jieruo Gu³, ¹Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine, Third Affiliated Hospital of Sun Yat-sen University, GuangZhou, China
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by chronic stimulation of the innate immune system by endogenous nucleic acids through toll-like receptors (TLRs) pathway, which…
Abstract Number: 1617 • 2013 ACR/ARHP Annual Meeting
Toll-Like Receptor 3 Plays a Role In Loss Of Tolerance To The Ro/SSA Auto-Antigen In Systemic Lupus Erythematosus
Julie Ducreux¹, Christine Galant², Julie Verbeeck², Pierre Coulie³, Benoît Van den Eynde³, Frédéric A. Houssiau¹ and Bernard Lauwerys², ¹Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Institut de Duve, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Toll-like Receptor (TLR)7 and TLR9 play a role in the pathogenesis of systemic lupus erythematosus (SLE) by inducing Interferon (IFN)-α and IFN-induced genes expression.…
Abstract Number: 628 • 2013 ACR/ARHP Annual Meeting
Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-α Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus
Nicholas A. Young¹, Lai-Chu Wu¹, Craig Burd², Alexandra Friedman¹, Benjamin Kaffenberger¹, Murugesan Rajaram³, Larry S. Schlesinger⁴, Hayley James⁵, Margaret Shupnik⁶ and Wael N. Jarjour⁷, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Molecular Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Center for Microbial Interface Biology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Asthma, Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, VA, ⁶Endocrinology; Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Epidemiological data suggests that females of child-bearing age are more resistant to infectious disease. The sex hormone estrogen (E2) is present at elevated levels…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].