Abstracts tagged "systemic lupus erythematosus (SLE) and tolerance"

Abstract Number: 142 • 2018 ACR/ARHP Annual Meeting
Peripheral CD4+CD25+Foxp3+T Regulatory Cells Absolutely Reduce in Patients with Systemic Lupus Erythematosus
Xiao-Qing Liu¹, Na-Lin Lai², Yanan Duan¹, Junwei Chen¹, Xiao-Feng Li³ and Chong Gao⁴, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, China, ³Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA
Background/Purpose: Regulatory T (Treg) cells, with the capacity to suppress immune responses, and effector T (Teff) cells, to promote inflammation, have been intensively studied in…
Abstract Number: 1822 • 2016 ACR/ARHP Annual Meeting
CD4+ T Cell Lymphopenia Is Associated with Deficient Ubiquitination of the Cell Cycle Inhibibitor p27kip1 By the E3 Ligase Casitas B-Lineage Lymphoma-b in Patients with Systemic Lupus Erythematosus
Diana Gómez-Martín, Jorge Romo-Tena, Javier Merayo-Chalico and Jorge Alcocer-Varela, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Lymphopenia has been associated with the development of autoimmune diseases. Particularly, in patients with Systemic Lupus Erythematosus (SLE) is a common clinical feature. However,…
Abstract Number: 1616 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factors 3 and 5 As Key Elements Of The Interferon Signature On Plasmacytoid Dendritic Cells From Systemic Lupus Erythematosus Patients
Diana Gómez-Martín¹, Karina Santana-de Anda², Adriana Elizabeth Monsivais-Urenda³, Sandra Rajme-Lopez⁴, Luis Aparicio-Vera⁴, Jorge Alcocer-Varela¹ and Roberto González-Amaro³, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico, ³Department of Immunology, Facultad de Medicina. UASLP, San Luis Potosí, Mexico, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico
Background/Purpose: Plasmacytoid dendritic cells (pDC) are considered the main source of type-I interferon (IFN-I). The interferon signature has been widely associated to systemic lupus erythematosus…
Abstract Number: 2325 • 2012 ACR/ARHP Annual Meeting
PD-1 Signaling Promotes Suppressive Function of CD4⁺ Regulatory T Cells in (New Zealand Black x New Zealand White )F₁ Lupus-Prone Mice in a Dose-Dependent Manner
Maida Wong¹, Antonio La Cava² and Bevra H. Hahn³, ¹Internal Medicine/Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²Internal Medicine/Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Programmed death-1 (PD-1) has been regarded as a negative regulatory signal in T cells. Our laboratory has shown that PD-1 is important in T…

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