Abstracts tagged "Systemic JIA"

Abstract Number: 2293 • 2014 ACR/ARHP Annual Meeting
Preliminary Results from the Childhood Arthritis and Rheumatology Research Alliance Systemic JIA Consensus Treatment Plans Pilot Study
Yukiko Kimura¹, Esi Morgan-DeWitt², Kelly L. Mieszkalski³, Thomas Brent Graham⁴, Timothy Beukelman⁵, Maria F. Ibarra⁶, Norman T. Ilowite⁷, Marisa S. Klein-Gitelman⁸, Karen Onel⁹, Sampath Prahalad¹⁰, Marilynn G. Punaro¹¹, Sarah Ringold¹², Dana Toib¹³, Heather Van Mater¹⁴, Pamela F. Weiss¹⁵ and Laura Schanberg¹⁶, ¹Pediatric Rheumatology, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ²Pediatric rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Dept of Pediatrics, Duke University Medical Center, Durham, NC, ⁴Pediatric Rheumatology, Vanderbilt Children's Hospital, Nashville, TN, ⁵Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁷Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ⁸Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁹Division of Pediatric Rheumatology, University of Chicago, Chicago, IL, ¹⁰Emory University School of Medicine, Atlanta, GA, ¹¹Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, ¹²Seattle Children's Hospital, Seattle, WA, ¹³St. Christopher's Hospital for Children, Philadelphia, PA, ¹⁴Duke Pediatric Rheumatology, Duke University Medical Center, Hillsborough, NC, ¹⁵Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ¹⁶Duke University, Durham, NC
Background/Purpose: Treatment options for systemic JIA (sJIA) have recently expanded to include IL1 and IL6 inhibitors in addition to traditional treatments such as glucocorticoids (GC)…
Abstract Number: 2296 • 2014 ACR/ARHP Annual Meeting
Tocilizumab Therapy in Children with Systemic Juvenile Idiopathic Arthritis. DATA from Russian Register of Sjia
Ekaterina Alexeeva^1,2, Saniya Valieva¹, Rina Denisova¹, Tatyana Bzarova¹, Kseniya Isayeva¹, Tatyana Sleptsova¹, Elena Mitenko¹, Evgeniya Chistyakova^1,2, Anna Fetisova¹ and Olga Lomakina³, ¹Rheumatology, Scientific Center of Children's Health of RAMS, Moscow, Russia, ²I.M.Sechenov First Moscow State Medical University, Moscow, Russia, ³Scientific Center of Children's Health of RAMS, Moscow, Russia
Background/Purpose Systemic Juvenile Idiopathic Arthritis (sJIA) is classified as an acquired autoinflammatory disease. The interleukin-1 and interleukin-6 play a pivotal role in pathogenesis of this…
Abstract Number: 2297 • 2014 ACR/ARHP Annual Meeting
Efficacy of Canakinumab in Patients with Systemic Juvenile Idiopathic Arthritis (SJIA) using JADAS Criteria – an Analysis of 12-Week Pooled Data
A. Ravelli¹, H. I. Brunner², N. Ruperto¹, P. Quartier³, A. Consolaro⁴, N.M. Wulffraat⁵, K. Lheritier⁶, C. Gaillez⁶, A. Martini¹ and D.J. Lovell², ¹PRINTO-Istituto Gaslini, Genova, Italy, ²PRCSG, Cincinnati, OH, ³Necker-Enfants Malades Hospital, Paris, France, ⁴Pediatria II, PRINTO-Istituto Gaslini, Genova, Italy, ⁵UMC Utrecht, Utrecht, Netherlands, ⁶Novartis Pharma AG, Basel, Switzerland
Background/Purpose Chronic active disease and persistent synovial inflammation can lead to structural damage, joint destruction and impairment of physical function in patients with systemic juvenile…
Abstract Number: 2300 • 2014 ACR/ARHP Annual Meeting
Biologic Treatment in Systemic Juvenile Idiopathic Arthritis: Single Center Experience
Buthaina Al adba¹, Rayfel Schneider² and Earl Silverman³, ¹paediatric rheumatology, sickkids hospital, Toronto, ON, Canada, ²Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Rheumatology, Hosp for Sick Children, Toronto, ON, Canada
Background/Purpose: The prevalence of juvenile idiopathic arthritis (JIA) is approximately 3.3/1000 children and 10- 15% have the systemic form (SJIA). Biologics, specifically anti-IL -1 and…
Abstract Number: 1901 • 2014 ACR/ARHP Annual Meeting
Interferon-γ (IFNγ) in Macrophage Activation Syndrome (MAS) Associated with Systemic Juvenile Idiopathic Arthritis (sJIA). High Levels in Patients and a Role in a Murine MAS Model
Claudia Bracaglia¹, Ivan Caiello¹, Kathy De Graaf², Giovanni D'Ario², Florence Guilhot², Walter Ferlin², Lidia Meli¹, Giusi Prencipe¹, Sergio Davì³, Grant Schulert⁴, Angelo Ravelli⁵, Alexei Grom⁶, Cristina De Min² and Fabrizio De Benedetti Sr.¹, ¹Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, ²Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland, ³Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Istituto Giannina Gaslini and University of Genova, Genova, Italy, ⁶Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: IFNγ is the pivotal mediator in murine models of primary HLH. Given the similarities between primary and secondary (sHLH), including MAS, we analyzed IFNγ…
Abstract Number: 1900 • 2014 ACR/ARHP Annual Meeting
HLA-DRB1*1101, Regulatory Variants of the MHC, and a Regulatory Region Near an Intergenic Long Noncoding RNA on Chromosome 1 Are Risk Factors for Systemic Juvenile Idiopathic Arthritis
Michael J. Ombrello¹, Elaine F. Remmers², Ioanna Tachmazidou³, Alexei Grom⁴, Dirk Föll⁵, Alberto Martini⁶, Marco Gattorno⁷, Seza Ozen⁸, Sampath Prahalad^9,10, Andrew S. Zeft¹¹, John F. Bohnsack¹², Norman T. Ilowite¹³, Jane L. Park¹⁴, Elizabeth D. Mellins¹⁵, Ricardo A. G. Russo¹⁶, Claudio A. Len¹⁷, Sheila K. Feitosa de Oliveira¹⁸, Rae SM Yeung¹⁹, Lucy R. Wedderburn^20,21, Jordi Anton²², Tobias Schwarz²³, Buhm Han²⁴, Richard H. Duerr²⁵, Jean-Paul Achkar²⁶, M. Ilyas Kamboh²⁷, Kenneth M. Kaufman²⁸, Leah C. Kottyan²⁸, Dalila Pinto²⁹, Stephen Scherer³⁰, Marta E. Alarcón-Riquelme³¹, Elisa Docampo Martinez³², Xavier Estivill³³, Ahmet Gul³⁴, Colleen Satorius³⁵, Paul I.W. de Bakker^36,37,38, Soumya Raychaudhuri^37,39,40, Carl D. Langefeld⁴¹, Susan D. Thompson⁴², Eleftheria Zeggini³, Wendy Thomson⁴³, Daniel L. Kastner⁴⁴, Patricia Woo⁴⁵ and International Childhood Arthritis Genetics (INCHARGE) Consortium, ¹Translational Genetics and Genomics Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany, ⁶University of Genova, Genova, Italy, ⁷Pediatric Rheumatology, Instituto Giannina Gaslini, Genoa, Italy, ⁸Deptartment. of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey, ⁹Emory University School of Medicine, Atlanta, GA, ¹⁰Children's Healthcare of Atlanta, Atlanta, GA, ¹¹Pediatrics Rheumatology, Cleveland Clinic, Cleveland, OH, ¹²Pediatriacs, University of Utah, Salt Lake City, UT, ¹³Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ¹⁴Pediatric Rheumatology, Stanford University Medical Center, Stanford, CA, ¹⁵Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA, ¹⁶Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁷Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil, ¹⁸Pediatric Rheumatology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁹Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²⁰University College London (UCL) Institute of Child Health, London, United Kingdom, ²¹Great Ormond Street Hospital, London, United Kingdom, ²²Pediatric Rheumatology Unit. Hospital Sant Joan de Déu. Universitat de Barcelona, Barcelona, Spain, ²³Pediatric rheumathology and osteology, University of Wuerzburg, Wuerzburg, Germany, ²⁴Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, ²⁵Department of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, ²⁶Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, ²⁷Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, ²⁸Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²⁹Genetics and Genomi Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, ³⁰The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada, ³¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³²Unit of Animal Genomics, GIGA-Université de Liège, LIege, Belgium, ³³Genetic Causes of Disease Laboratory, Center for Genomic Regulation, Barcelona, Spain, ³⁴Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³⁵National Human Genome Research Institute, Bethesda, MD, ³⁶Brighan and Women's Hospital, Harvard Medical School, Boston, MA, ³⁷Broad Institute of MIT and Harvard, Cambridge, MA, ³⁸University Medical Center Utrecht, Utrecht, Netherlands, ³⁹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁴⁰Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁴¹Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴²Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴³Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁴⁴Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ⁴⁵Paediatric Rheumatology Unit, University College London, London, United Kingdom
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory disease of unknown etiology. We utilized a genomic approach to interrogate the molecular pathogenesis of…
Abstract Number: 931 • 2014 ACR/ARHP Annual Meeting
Response to Canakinumab Treatment Is Maintained in Systemic Juvenile Idiopathic Arthritis Patients
N.M. Wulffraat^1,2, N. Ruperto², H.I. Brunner³, S. Oliveira², Y. Uziel², K. Nistala², R. Cimaz², M. Ferrandiz², B. Flato², M.L. Gamir², I. Koné-Paut², C. Gaillez⁴, K. Lheritier⁴, K. Abrams⁵, A. Martini² and D.J. Lovell³, ¹Pediatric Rheumatology, UMC Utrecht, Utrecht, Netherlands, ²PRINTO-Istituto Gaslini, Genova, Italy, ³PRCSG, Cincinnati, OH, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Canakinumab, a selective, human, anti-interleukin (IL) -1β monoclonal antibody, is approved for the treatment of systemic juvenile idiopathic arthritis (SJIA) patients (≥ 2 years…
Abstract Number: 319 • 2014 ACR/ARHP Annual Meeting
Systemic Juvenile Idiopathic Arthritis and Exposure to Fine Particulate Air Pollution
Andrew S. Zeft¹, Sampath Prahalad², Rayfel Schneider³, Alexei Grom⁴, Fatma Dedeoglu⁵, Pamela F. Weiss⁶, Carter Mix⁷ and C. Arden Pope⁸, ¹Pediatrics, Rheumatology, The Cleveland Clinic, Cleveland, OH, ²Emory University, Atlanta, GA, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵on behalf of CARRAnet Investigators, Palo Alto, CA, ⁶Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Brigham Young University, Provo, UT, ⁸Economics, Brigham Young University, Provo, UT
Background/Purpose: Environmental factors are understood to play a pathogenic role in the etiology of Systemic Onset Juvenile Idiopathic Arthritis (SJIA). Fine particulate matter (aerodynamic diameter…
Abstract Number: 316 • 2014 ACR/ARHP Annual Meeting
Cytokines in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Tipping the Balance Between Interleukin-18 and Interferon-Gamma
Karen Put¹, Anneleen Avau¹, Ellen Brisse¹, Tania Mitera¹, Stéphanie Put¹, Paul Proost², Brigitte Bader-Meunier³, Rene Westhovens⁴, Benoît Van den Eynde⁵, Ciriana Orabona⁶, Francesca Fallarino⁶, Lien De Somer⁷, Thomas Tousseyn⁸, Pierre Quartier³, Carine Wouters⁷ and Patrick Matthys¹, ¹University of Leuven, Laboratory of Immunobiology, Rega Institute, Leuven, Belgium, ²University of Leuven, Laboratory of Molecular Immunology, Rega Institute, Leuven, Belgium, ³Pediatric Rheumatology, IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France, ⁴University of Leuven, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration; Rheumatology, University Hospital Leuven, Leuven, Belgium, ⁵Institut de Duve, Université catholique de Louvain, Brussels, Belgium, ⁶Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy, ⁷University of Leuven, Laboratory of Pediatric Immunology, University Hospital Leuven, Leuven, Belgium, ⁸University of Leuven, Department of Imaging and Pathology, Leuven, Belgium
Background/Purpose To study the role of interferon-gamma (IFN-γ) in the pathogenesis of systemic juvenile idiopathic arthritis (sJIA) and macrophage activation syndrome (MAS) by searching for…
Abstract Number: 271 • 2013 ACR/ARHP Annual Meeting
Baseline Characteristics Of Patients With Active Systemic JIA On Canakinumab Therapy Successfully Discontinuing Corticosteroids: Secondary Analyses From A Pivotal PHASE 3 Study
Hermine Brunner¹, Nicolino Ruperto², Tamás Constantin³, Nico Wulffraat^2,4, Gerd Horneff⁴, Jordi Anton², Reinhard Berner², Fabrizia Corona⁵, Rubén J. Cuttica⁶, Marine Desjonqueres², Michel Fischbach², Maria Alessio², Alice Chieng², Wolfgang Emminger², Elie Haddad⁷, Karine Lheritier⁸, Ken Abrams⁹, Josef Hruska⁸, Daniel J. Lovell⁷ and Alberto Martini², ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Pediatric Rheumatology International Trials Organization (PRINTO)-Istituto Gaslini, Genova, Italy, ³Pediatric Rheumatology, University Childrens Hospital, Budapest, Hungary, ⁴PRINTO, Genoa, Italy, ⁵PRINTO-Istituto Gaslini, Genova, Italy, ⁶Hospital de Niños Pedro de Elizalde - University of Buenos Aires, Buenes Aires, Argentina, ⁷Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati, OH, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Interleukin-1β (IL-1β) is a key cytokine in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA). Canakinumab (CAN), a selective fully human anti-IL-1β monoclonal antibody,…
Abstract Number: 275 • 2013 ACR/ARHP Annual Meeting
Changes In Serum IL-18 Level In Systemic Juvenile Idiopathic Arthritis Patients Who Attained Drug-Free Remission By Tocilizumab
Tomohiro Kubota¹, Syuji Takei², Yuichi Yamasaki¹, Junko Yasumura³, Naomi Kuwada⁴, Yukiko Nonaka⁵, Tomoko Takezaki⁵, Tsuyoshi Yamatou⁵, Tomokazu Nagakura⁶, Yasuhito Nerome⁵, Hiroyuki Imanaka⁵ and Harumi Akaike⁵, ¹Dept of Pediatrics, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ²School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ³Dept of Pediatrics, Graduate School of Biomedical Sciences, Faculty of Medicine, Hiroshima University, Hiroshima City, Japan, ⁴Dept of Pediatrics, Faculuty of Medicine, Kumamoto University, Kumamoto City, Japan, ⁵Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, ⁶Department of Pediatrics, House of Meguminoseibo, Usuki, Japan
Background/Purpose: Tocilizumab (TCZ), anti-human interleukin-6 receptor monoclonal antibody, was the first biologic agent used in the treatment of systemic juvenile idiopathic arthritis (sJIA) in Japan.…
Abstract Number: 229 • 2013 ACR/ARHP Annual Meeting
Positron Emission Tomography Assessment Of Children With Systemic-Onset Juvenile Idiopathic Arthritis
Taichi Kanetaka¹, Tomo Nozawa¹, Kenichi Nishimura¹, Masako Kikuchi¹, Tomomi Sato¹, Nodoka Sakurai¹, Ryoki Hara², Kazuko Yamazaki¹ and Shumpei Yokota¹, ¹Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Japan, ²Yokohama City University School of Medicine, Yokohama, Japan
Background/Purpose: Systemic-onset juvenile idiopathic arthritis (s-JIA) is a systemic inflammatory disorder manifesting spiking fever, rheumatoid rash, and arthritis. The onset is nonspecific, and may be…
Abstract Number: 2790 • 2013 ACR/ARHP Annual Meeting
The Research In Arthritis In Canadian Children Emphasizing Outcomes (ReACCh Out) Cohort: Are We Achieving Clinically Important Outcomes?
Deborah M. Levy¹, Shirley ML Tse¹, Elizabeth Stringer², Jaime Guzman³, Roberta A. Berard⁴, Karen Watanabe Duffy⁵, Dax Rumsey¹, Mercedes O. Chan³, Rosie Scuccimarri⁶, Adam M. Huber⁷, Lori B. Tucker³, Rae SM Yeung¹, Ciaran M. Duffy⁵, Kiem Oen⁸ and The ReACCh Out Investigators⁹, ¹Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ²Department of Rheumatology, IWK Health Centre, Halifax, NS, Canada, ³Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ⁴Children's Hospital of Western Ontario, London, ON, Canada, ⁵Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁶McGill University, Montreal, QC, Canada, ⁷Dalhousie University, Halifax, NS, Canada, ⁸Pediatrics, Children's Hospital of Winnipeg and University of Manitoba, Winnipeg, MB, Canada, ⁹The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Recent data suggests that achievement of inactive disease and early disease remission may result in improved outcomes for patients with juvenile idiopathic arthritis (JIA). …
Abstract Number: 2169 • 2013 ACR/ARHP Annual Meeting
Short Term Efficacy Of Biologic Agents In Patients With Systemic Juvenile Idiopathic Arthritis: Network Meta-Analysis Of Randomized Trials
Simon Tarp¹, Gil Amarilyo², Ivan Foeldvari³, Neta Cohen⁴, Tracy D. Pope⁵, Jennifer M.P. Woo⁶, Robin Christensen¹ and Daniel Furst⁵, ¹Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, ²Dana-Dwek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ³Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ⁴Dana-Duek Children's hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵David Geffen School of Medicine, University of California, Los Angeles, CA, ⁶Pediatric Rheumatology, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is a severe subtype of JIA, which includes systemic features such as fever, rash, elevated inflammatory markers along with…
Abstract Number: 1784 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of First Line Use Of Recombinant IL-1RA Treatment In Steroid naïve Systemic Juvenile Idiopathic Arthritis: Results Of a Prospective Cohort Study
S.J. Vastert¹, Wilco de Jager², Bo Jan Noordman², Dirk Holzinger³, Wietse Kuis⁴, Berent J. Prakken² and Nico M. Wulffraat⁵, ¹Pediatric Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ²Pediatric Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Institute of Immunology, University Muenster, Muenster, Germany, ⁴Pediatric immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵UMC Utrecht, Utrecht, Netherlands
Background/Purpose: To perform a prospective cohort study with recombinant IL-1RA (Anakinra, rIL-1RA) as first-line therapy in newly onset sJIA. Methods: Patients fulfilled the ILAR criteria…

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