Systemic JIA and monocytes Archives - ACR Meeting Abstracts

Abstract Number: 2414 • ACR/ARHP Annual Meeting 2016
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 310 • ACR/ARHP Annual Meeting 2014
Differential Expression of microRNA in Monocytes from Children with Systemic Juvenile Idiopathic Arthritis: Implications for Polarized Phenotype
Grant Schulert¹, Ndate Fall², Nan Shen³ and Alexei Grom⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, OH, China, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, and the predominant effector cells are mononuclear phagocytes rather than lymphocytes as in…
Abstract Number: 2188 • ACR/ARHP Annual Meeting 2013
Role of Interleukin-1 in Abnormal Monocyte Phenotype in Systemic Onset Juvenile Idiopathic Arthritis
Yujuan Zhang^1,2, Claudia Macaubas², Clarissa Klein³, M. Virginia Pascual⁴, Arielle Hay⁵, Susan D. Thompson⁶, Christy I. Sandborg³, Norman T. Ilowite⁷ and Elizabeth D. Mellins⁸, ¹Pediatrics, Stanford University Med Ctr, Palo Alto, CA, ²Pediatric Rheumatology, Stanford University Med Ctr, Stanford, CA, ³Stanford University Med Ctr, Stanford, CA, ⁴Baylor Institue for Immunology Research, Dallas, TX, ⁵The Children's Hospital at Montefiore, Bronx, NY, ⁶Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ⁸Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA
Background/Purpose: Monocytes undergo phenotype changes when exposed to different microenvironments: the classic proinflammatory M1 phenotype, alternative regulatory M2 phenotype and M2-like phenotype, are each regulated…

Abstracts tagged "Systemic JIA and monocytes"

Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms

Differential Expression of microRNA in Monocytes from Children with Systemic Juvenile Idiopathic Arthritis: Implications for Polarized Phenotype

Role of Interleukin-1 in Abnormal Monocyte Phenotype in Systemic Onset Juvenile Idiopathic Arthritis