Abstracts tagged "Systemic JIA and monocytes"

Abstract Number: 2414 • 2016 ACR/ARHP Annual Meeting
Microrna Associated with Active Systemic Juvenile Idiopathic Arthritis Regulate CD163 Expression in Polarized Macrophages through Two Distinct Mechanisms
Thuy Do¹, Rachel Tan², Mark Bennett², Mario Medvedovic², Nan Shen³, Sherry Thornton¹, Alexei Grom¹ and Grant Schulert⁴, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²University of Cincinnati, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: CD163 is a hemoglobin scavenger receptor and innate pattern recognition receptor, and a marker of activated monocytes and macrophages. It is also expressed on…
Abstract Number: 310 • 2014 ACR/ARHP Annual Meeting
Differential Expression of microRNA in Monocytes from Children with Systemic Juvenile Idiopathic Arthritis: Implications for Polarized Phenotype
Grant Schulert¹, Ndate Fall², Nan Shen³ and Alexei Grom⁴, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rheumatology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, OH, China, ⁴Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is an autoinflammatory disease of childhood, and the predominant effector cells are mononuclear phagocytes rather than lymphocytes as in…
Abstract Number: 2188 • 2013 ACR/ARHP Annual Meeting
Role of Interleukin-1 in Abnormal Monocyte Phenotype in Systemic Onset Juvenile Idiopathic Arthritis
Yujuan Zhang^1,2, Claudia Macaubas², Clarissa Klein³, M. Virginia Pascual⁴, Arielle Hay⁵, Susan D. Thompson⁶, Christy I. Sandborg³, Norman T. Ilowite⁷ and Elizabeth D. Mellins⁸, ¹Pediatrics, Stanford University Med Ctr, Palo Alto, CA, ²Pediatric Rheumatology, Stanford University Med Ctr, Stanford, CA, ³Stanford University Med Ctr, Stanford, CA, ⁴Baylor Institue for Immunology Research, Dallas, TX, ⁵The Children's Hospital at Montefiore, Bronx, NY, ⁶Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ⁸Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA
Background/Purpose: Monocytes undergo phenotype changes when exposed to different microenvironments: the classic proinflammatory M1 phenotype, alternative regulatory M2 phenotype and M2-like phenotype, are each regulated…

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