Abstracts tagged "synovium and tocilizumab"

Abstract Number: 2869 • ACR/ARHP Annual Meeting 2017
Significant Decrease of T-Cells but Not Macrophages in the Synovium of Patients with Active Rheumatoid Arthritis after Treatment with Tocilizumab
Katerina Chatzidionysiou¹, Marianne Engström¹, Erik af Klint¹, Aase Hensvold¹ and Anca I Catrina², ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Tocilizumab (TCZ) is an anti-IL6R monoclonal antibody approved for the treatment of Rheumatoid Arthritis (RA). There is limited data on synovial tissue histology changes.…
Abstract Number: 3099 • ACR/ARHP Annual Meeting 2015
Differential Effects of IL-6 Blockade Tocilizumab and TNF Inhibitors on the Reduced Angiogenesis and Lining Layer Degeneration in Synovial Tissues from Patients with Rheumatoid Arthritis
Hirohata Shunsei¹, Asami Abe^2,3, Akira Murasawa³, Tetsuya Tomita⁴ and Hideki Yoshikawa⁴, ¹Rheumatology and infectious diseases, Kitasato University School of Medicine, Kanagawa, Japan, ²Rheumatplogy, Niigata Rheumatic Center, Shibata, Japan, ³Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ⁴Department of Orthopedics, Osaka University Graduate School of Medicine, Suita Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of synovial tissues, leading to the destruction of joint structures. TNF inhibitors, including…