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Abstracts tagged "synovium and rituximab"

  • Abstract Number: 1754 • ACR/ARHP Annual Meeting 2012

    Disruption of Dominant B-Cell and Plasma Cell Clones in Rheumatoid Arthritis Synovium by Rituximab Correlates with Treatment Response

    Marieke E. Doorenspleet1, Paul L. Klarenbeek1, Maartje J. Boumans1, Rogier M. Thurlings2, Rebecca E. Esveldt1, Barbera D. van Schaik3, Antoine H. van Kampen3, Danielle M. Gerlag4, Frank Baas5, Paul-Peter Tak1, Robert M. Plenge6 and Niek de Vries1, 1Division of Clinical Immunology and Rheumatology, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 2Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Bioinformatics, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Department of Genome Analysis, Academic Medical Center of the University of Amsterdam, Amsterdam, Netherlands, 6Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Autoreactive B lymphocytes are thought to play an important role in rheumatoid arthritis (RA). B-cell depletion therapy by rituximab (RTX) has shown that targeting…

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