Abstracts tagged "synovial fluid"

Abstract Number: 1278 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity and Joint Damage Locus Cia25/Pia42 Is a New Genetic Regulator of the Invasive Properties of Synovial Fibroblasts
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic and commonly disabling disease with a prevalence of 1% world-wide. Disease remission is rarely achieved with current treatments…
Abstract Number: 2873 • 2013 ACR/ARHP Annual Meeting
The Ion Channel TRPV2 Is New Suppressor of Arthritis Severity and Joint Damage
Teresina Laragione^1,2, Max Brenner^1,2, Christine Beeton³ and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY, ³Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic disease associated with increased risk of developing disability. Disease remission is still rarely achieved and better…
Abstract Number: 1294 • 2013 ACR/ARHP Annual Meeting
Anti-Inflammatory Effect Of Resveratrol As a Dietary Supplement In An Antigen-Induced Arthritis Rat Model
Romina R. Riveiro-Naveira¹, Jesus Loureiro¹, Alberto Centeno-Cortés², Eduardo López-Peláez², Carlos Vaamonde-García¹, M. Noa Valcárcel-Ares¹, Francisco J. Blanco³ and Maria J. López-Armada¹, ¹Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, ²Experimental Surgery Unit, CHU A Coruña, A Coruña, Spain, ³Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Inflammatory cells like macrophages, lymphocytes and neutrophils in hyperplasic synovial tissue have been identified as key players in the onset and development of rheumatoid…
Abstract Number: 2874 • 2013 ACR/ARHP Annual Meeting
Biological Roles of C5orf30 In Rheumatoid Arthritis Synovial Fibroblasts
Munitta Muthana¹, Holly Davies², Sachin Khetan³, Gbadebo Adeleke Adeleke⁴, Sarah Hawtree¹ and Anthony G. Wilson⁵, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²University of Sheffield, Sheffield, United Kingdom, ³Infection and immunity, Dr, Sheffield, United Kingdom, ⁴Infection and Immunity, Dr, Sheffield, United Kingdom, ⁵Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: A recent genome wide association study identified the variant rs26232 in the first intron of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility…
Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting
Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis
Katalin Mikecz¹, Julia Kurko¹, Timea Ocsko¹, Andras Vida¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Joel A. Block², Robert S. Katz³, Anjali Nair², Carla R. Scanzello⁴ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush Medical College, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
Abstract Number: 2731 • 2013 ACR/ARHP Annual Meeting
An Acetyl-Histone Mimetic Blocks Proinflammatory Activation Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
P. A. Kabala¹, A.M. Grabiec¹, C. Angiolilli¹, Nicholas Smithers², Jason Witherington³, Paul Peter Tak⁴, Rabinder Prinjha³ and Kris A. Reedquist⁵, ¹Department of Experimental Immunology, Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Immuno Inflammation, GlaxoSmithKline, Stevenage, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁵Department of Experimental Immunology and Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Genetic backgrounds and environmental factors do not completely explain the etiology of disease and predisposition to rheumatoid arthritis (RA), and increasing attention has turned…
Abstract Number: 1149 • 2013 ACR/ARHP Annual Meeting
Phenotypic and Molecular Profile Of Innate Lymphoid Cells In Chronic Synovial Inflammation
Hulda S. Hreggvidsdottir^1,2, Maureen C. Turina¹, Troy Noordenbos^1,3, Marius Munneke⁴, Charlotte Peters², Jochem Bernink², Jenny Mjosberg⁵, Dominique L. Baeten⁶ and Hergen Spits², ¹Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Hematology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically…
Abstract Number: 2418 • 2013 ACR/ARHP Annual Meeting
The Transmembrane Protein Tyrosine Phosphatase Kappa Promotes Aggressiveness Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Stephanie M. Stanford¹, William B. Kiosses², Amanda M. Campbell³, Michael F. Maestre³, David L. Boyle⁴, Gary S. Firestein⁴ and Nunzio Bottini³, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). In RA these cells…
Abstract Number: 930 • 2013 ACR/ARHP Annual Meeting
The Endocannabinoid Anandamide Modulates Adhesion, Proliferation and The Production Of Inflammatory Mediators In Rheumatoid Arthritis Synovial Fibroblasts By Activating CB₁, TRPV1, TRPA1 and Non-Cannabinoid Receptor Targets
Torsten Lowin, Angelika Graeber and Rainer H. Straub, Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs…
Abstract Number: 2424 • 2013 ACR/ARHP Annual Meeting
Investigation Of The Role Of Histone Deacetylases In Rheumatoid Arthritis Synovial Fibroblasts
Sarah Hawtree¹, Munitta Muthana¹, Sarah Aynsley¹, J. Mark Wilkinson² and Anthony G. Wilson³, ¹Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, ³Infection & Immunity, University of Sheffield, Sheffield, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS).…
Abstract Number: 934 • 2013 ACR/ARHP Annual Meeting
Interleukin-12B Is Up-Regulated By Decoy Receptor 3 In Specifically Rheumatoid Synovial Fibroblasts
Koji Fukuda¹, Yasushi Miura^1,2, Toshihisa Maeda¹, Shinya Hayashi³ and Masahiro Kurosaka³, ¹Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand (FasL), LIGHT,…
Abstract Number: 2429 • 2013 ACR/ARHP Annual Meeting
Enhanced Responsiveness To Stimulation and Increased Extrusion Of Extracellular Traps By Rheumatoid Arthritis Neutrophil Granulocytes and of Healthy Control Neutrophils to Serum and Synovial Fluid From Rheumatoid Arthritis Patients
Stavros Giaglis^1,2, Chanchal Sur Chowdhury³, Ulrich A. Walker⁴, Andreas Buser⁵, Sinuhe Hahn⁶ and Paul Hasler¹, ¹Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ⁵Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, ⁶Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Polymorphonuclear granulocytes (PMNs) are the most abundant immune cell population in the synovial fluid in the joints of patients with rheumatoid arthritis (RA) and…
Abstract Number: 916 • 2013 ACR/ARHP Annual Meeting
Role Of CD20+ B Cells As Antigen-Presenting Cells In Arthritis
Estefania Armas-Gonzalez¹, Ana Diaz-Martin¹, María Jesús Dominguez-Luis¹, Maria Teresa Arce-Franco¹, Ada Herrera-Garcia¹, Vanesa Hernandez¹, Alicia Usategui², Jose L. Pablos³, Sagrario Bustabad¹ and Federico Diaz-Gonzalez⁴, ¹Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, ²Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain, ³Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ⁴University of La Laguna, Hospital Universitario de Canarias, La Laguna, Spain
Background/Purpose: B cells participate in the pathogenesis of rheumatoid arthritis (RA) through a mechanism still not fully understood. In RA, B cells are believed to…
Abstract Number: 2396 • 2013 ACR/ARHP Annual Meeting
PI3Kdelta Regulates Invadosome Formation and Invasiveness Of Fibroblast-Like Synoviocyte In Rheumatoid Arthritis
Beatrix Bartok¹ and G. S. Firestein², ¹Rheumatology, UCSD School of Medicine, La Jolla, CA, ²Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the intimal lining are major effectors of cartilage damage in rheumatoid arthritis (RA). PI3Kdelta, a member of the Class IA…
Abstract Number: 497 • 2013 ACR/ARHP Annual Meeting
Development Of a Novel Bispecific Therapeutic For Arthritic Diseases
Mathieu Ferrari¹, Shimobi Onuoha¹, Tahereh Kamalati², Daniele Sblattero³ and Costantino Pitzalis⁴, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London, London, United Kingdom, ²University College of London, London, United Kingdom, ³University of Eastern Piedmont, Novara, Italy, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom
Background/Purpose: Despite the obvious success of current biological agents for treatment of rheumatoid arthritis (RA), achievement of broader efficacy and improved safety profile remains an…

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