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Abstracts tagged "synovial fluid"

  • Abstract Number: 310 • 2016 ACR/ARHP Annual Meeting

    A Novel One Stage Technique Applicable during Arthroscopy for the Mobilization of Synovial Mesenchymal Stromal Cells Towards Joint Regeneration

    Alam Khalil-Khan1, Thomas Baboolal2, Elena Jones3, Owen Wall4 and Dennis McGonagle3, 1Faculty of Medicine, Leeds institute of Rheumatic and Musculoskeletal Medicine,, Leeds, United Kingdom, 2PhD, Leeds, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Orthopaedic Surgery, Department of Trauma and Orthopaedics, Leeds, United Kingdom

    Background/Purpose: , The discovery of MSCs in the synovium and synovial fluid (SF) provided a potential mechanism for repairing cartilage “from the top down”. Indeed,…
  • Abstract Number: 380 • 2016 ACR/ARHP Annual Meeting

    Linear Discriminant Analysis of Cultured Fibroblast-like Synoviocytes Identifies 6 Candidate Genes Which Predict Extended Course in Juvenile Idiopathic Arthritis

    AnneMarie Brescia1, Megan Simonds2, Suzanne McCahan3, Tim Bunnell3, Kathleen E. Sullivan4 and Carlos D. Rosé1, 1Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, 2Nemours, Nemours Biomedical Research, Wilmington, DE, 3Nemours Biomedical Research, Wilmington, DE, 4Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: The goal of this project is the identification of informative synovial biomarkers to predict which children with oligoarticular juvenile idiopathic arthritis (JIA) will have…
  • Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting

    DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts  from OA and RA Patients

    Emmanuel Karouzakis1, Mojca Frank Bertoncelj2, Kerstin Klein1, Christoph Kolling3, Renate E. Gay1, Steffen Gay1 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland

    Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
  • Abstract Number: 1096 • 2016 ACR/ARHP Annual Meeting

    Augmentation of Wnt Signaling By IL-1β in Fibroblast-like Synoviocytes

    Satoshi Yamasaki1, Yusuke Yoshida2 and Eiji Sugiyama2, 1Hiroshima University Hospital, Hiroshima, Japan, 2Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose: Wnt family proteins canonically stabilize β-catenin to activate T-cell factor (TCF) for the transcription of several genes, including Runx2, which is important for osteoblastogenesis.…
  • Abstract Number: 1111 • 2016 ACR/ARHP Annual Meeting

    Huntingtin Interactin Protein 1 (HIP1) Regulates Receptor Tyrosine Kinases Mediated Activity and Cell Invasiness in Fibroblast-like Synoviocytes

    Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is a new arthritis severity gene recently identified in the Pristane and Collagen-induced arthritis (PIA, CIA) quantitative trait locus Cia25/Pia42…
  • Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Vijay Joshua1, Akilan Krishnamurthy1, Yanying Liu2, Aase Hensvold1, Sergiu-Bogdan Catrina3, Caroline Ospelt4, Vivianne Malmström5, Khaled Amara1, Johanna Steen1, Muhammad Sohel Mia1, Marianne Engström1, Heidi Wähämaa1, Jimmy Ytterberg1, Bence Rethi1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, 3Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, 5Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
  • Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting

    KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis

    Mark Tanner1, Redwan Huq1, Rajeev Tajhya1, Michael Pennington2, Teresina Laragione3, Pércio Gulko4 and Christine Beeton5, 1Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, 2Peptides International, Louisville, KY, 3Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX

    Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
  • Abstract Number: 1557 • 2016 ACR/ARHP Annual Meeting

    3-D Explant Method Facilitates the Study of Lymphocytes in Synovium and Reveals a Population of Resident Memory-like T Cells in Rheumatoid Arthritis

    Lauren Henderson1, Deepak Rao2, Nikola Teslovich3,4, Sandra King5, Fumitaka Mizoguchi6, Sarah Ameri6, Allyn Morris7, Christopher Elco8, James Lederer9, Scott Martin10, Barry Simmons10, John Wright10, Michael Brenner2, Soumya Raychaudhuri11,12,13,14,15, Peter Nigrovic1,16 and Robert Fuhlbrigge17,18, 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, 5Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 7Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, 8Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 9Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 10Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 11Divisions of Genetics and Rheumatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 12Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 13Partners Center for Personalized Genetic Medicine, Boston, MA, 14Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden, 15Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 16Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, 17Immunology, Boston Children's Hospital, Boston, MA, 18Dermatology, Brigham and Women’s Hospital, Boston, MA

    Background/Purpose: Tissue resident memory T (TRM) cells survive indefinitely in barrier tissues and mediate swift immunologic memory responses at sites of microbe entry. TRM cells…
  • Abstract Number: 2546 • 2015 ACR/ARHP Annual Meeting

    Targeting Synovial Fibroblasts By the Intra-Articular Delivery of microRNA-140-3p and -5p Ameliorates Experimental Autoimmune Arthritis

    Chrong-Reen Wang1, Jia-Shiou Peng2, Shih-Yao Chen3, Chao-Liang Wu4 and Ai-Li Shiau5, 1Rheum/Immun Sec/Int Med Dept, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 2Institute of Basic Medical Sciences, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 3Internal Medicine, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 4Biochemistry and Molecular Biology, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, 5Microbiology and Immunology, College of Medicine, National Cheng Kung University, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan

    Background/Purpose: Synovial fibroblasts (SF) with aberrant expression of microRNAs (miRNA) are critical pathogenic regulators of rheumatoid joint, and studies examining the effect of overexpressing or…
  • Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting

    Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis

    Sang-Yeob Lee1, Sung Won Lee2, Won Tae Chung2, Jae Ho Bae3, So Youn Park4 and Chi Dae Kim4, 1Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, 2Rheumatology, Dong-A University Hospital, Busan, South Korea, 3Biochemistry, Pusan national university, Yong -San, South Korea, 4Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea

    Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…
  • Abstract Number: 2703 • 2015 ACR/ARHP Annual Meeting

    Reduction in Matrix Metalloproteinase-1 and -2 Secretion from Fibroblast-like Synoviocytes after Induction of Adipogenesis By a Natural Peroxisome Proliferator-Activated Receptor Gamma Ligand, Arterpilin-C

    Eiji Sugiyama1, Satoshi Yamasaki1 and Je-Tae Woo2,3, 1Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, 2Department of Biological Chemistry, Chubu University, Aichi, Japan, 3JT WOO, Okinawa Research Center Co., Ltd, Okiawa, Japan

    Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles in rheumatoid arthritis (RA) by producing matrix metalloproteinase (MMP) and cytokines, and hence, these cells are a therapeutic…
  • Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting

    Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jin Kyun Park2, Eun Young Lee2, Eun Bong Lee2 and Yeong Wook Song2,3, 1Department of Molecular Medicine and Biopharmaceutical Sciences, BK21 plus Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…
  • Abstract Number: 2722 • 2015 ACR/ARHP Annual Meeting

    Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA

    Ikuko Masuda1,2, Kodo Okada3, Hisashi Yamanaka1 and Shigeki Momohara1, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, 3SANSHO, Co. Ltd., Tokyo, Japan

    Background/Purpose: Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including inhibitory effects of proliferation,…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 2815 • 2015 ACR/ARHP Annual Meeting

    A Comparison of Th17 Gene Expression in Psoriatic Arthritis Synovial Fluid and Peripheral Blood

    Fatima Abji1, Remy Pollock2, Kun Liang3, Vinod Chandran4 and Dafna Gladman4, 1Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 2University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 4Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a destructive inflammatory arthritis that develops in approximately 30% of patients with cutaneous psoriasis. Th17 cells infiltrate psoriatic skin and…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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