Abstracts tagged "synovial fluid"

Abstract Number: 1566 • 2016 ACR/ARHP Annual Meeting
Histone Lysine Methylation and STAT3 Differentially Regulate Constitutive and IL-6-Induced MMPs Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts
Yasuto Araki^1,2, Takuma Tsuzuki Wada^2,3, Yoshimi Aizaki^1,2, Kazuhiro Yokota¹, Hiroshi Kajiyama¹, Yu Funakubo Asanuma¹, Kojiro Sato¹, Hiromi Oda⁴ and Toshihide Mimura^1,2, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan, ³Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma, Japan, ⁴Orthopedic Surgery, Faculty of Medicine, Saitama Medical Univeristy, Morohongo Moroyama, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes progressive joint destruction. In spite of the modern medications, including biologic reagents, it…
Abstract Number: 1576 • 2016 ACR/ARHP Annual Meeting
Identifying Rheumatoid Arthritis Subtypes Using Synovial Tissue Gene Expression Profiling, Histologic Scoring and Clinical Correlates
Dana E. Orange¹, Susan M. Goodman², Phaedra Agius³, Ryan Cummings⁴, Kathleen Andersen¹, Robert Darnell⁵, Lionel Ivashkiv², Alessandra B. Pernis⁶, Edward F. DiCarlo⁷, Vivian P. Bykerk⁸ and Laura T. Donlin⁹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medicine, Hospital for Special Surgery, New York, NY, ³New York Genome Center, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵The New York Genome Center, New York, NY, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁷Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁸Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ⁹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: The histopathologic features of synovial tissue vary widely among patients with rheumatoid arthritis (RA) undergoing arthroplasty and the clinical significance of this variability is…
Abstract Number: 2110 • 2016 ACR/ARHP Annual Meeting
Synovial Fibroblasts Regulate B Cell Survival Via B Cell Activating Factor of the TNF Family (BAFF)
Torsten Lowin¹, Matthias Schneider² and Georg Pongratz³, ¹Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, ²Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Düsseldorf, Germany, ³Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) are one main contributor of joint destruction since they resist apoptosis and secrete pro-inflammatory cytokines and matrix…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
Abstract Number: 2156 • 2016 ACR/ARHP Annual Meeting
IL-6 and TNF-α Modulate Expressions of Cell Cycle Regulators of Rheumatoid Arthritis Fibroblast-like Synoviocytes
Kenta Kaneshiro¹, Teppei Hashimoto², Kohsuke Yoshida¹, Ayako Nakai¹, Naonori Hashimoto¹, Kohjin Suzuki¹, Koto Uchida¹, Yoshiko Kawasaki², Natsuko Nakagawa³, Nao Shibanuma⁴, Yoshitada Sakai⁵ and Akira Hashiramoto⁶, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ³Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁴Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: Iinterleukin(IL)-6 and tumor necrosis factor(TNF)-α play important roles in the pathogenesis of RA, however, it remains unclear how they affect or modulate the…
Abstract Number: 2561 • 2016 ACR/ARHP Annual Meeting
A Novel Pharmacological Action of MTX on RA Fibroblast-like Synoviocytes Via Circadian Clock Genes
Kohjin Suzuki¹, Kohsuke Yoshida¹, Teppei Hashimoto², Kenta Kaneshiro¹, Ayako Nakai¹, Naonori Hashimoto¹, Yoshiko Kawasaki², Nao Shibanuma³, Natsuko Nakagawa⁴, Yoshitada Sakai⁵ and Akira Hashiramoto⁶, ¹Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, ³Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁴Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, ⁵Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan
Background/Purpose: The circadian rhythm is disrupted in patients with rheumatoid arthritis (RA), and we have shown that tumor necrosis factor(TNF)-ƒ¿ inhibits the expression of circadian…
Abstract Number: 3216 • 2016 ACR/ARHP Annual Meeting
Integrated High-Dimensional Analyses Reveal a Pathologically Expanded ‘Peripheral’ B Cell-Helper T Cell Population in Rheumatoid Arthritis
Deepak Rao¹, Michael Gurish², Kamil Slowikowski³, Chamith Fonseka², Jennifer Marshall⁴, Yanyan Liu⁵, Laura T. Donlin⁶, Lauren Henderson⁷, Fumitaka Mizoguchi⁸, Nikola Teslovich⁹, Michael Weinblatt¹⁰, Elena Massarotti¹⁰, Jonathan Coblyn¹¹, Simon M. Helfgott¹⁰, Yvonne C. Lee¹², Derrick J. Todd¹⁰, Vivian P. Bykerk¹³, Susan M. Goodman¹⁴, Alessandra B. Pernis¹⁵, Lionel Ivashkiv¹⁴, Elizabeth W. Karlson¹⁰, Peter Nigrovic⁹, Andrew Filer¹⁶, Christopher Buckley¹⁷, James Lederer¹⁸, Soumya Raychaudhuri¹⁹ and Michael Brenner¹, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Rheumatology and Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁷Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ⁸Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Brigham and Women's Hospital and Harvard Medical School, Cambridge, MA, ¹⁰Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹²Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹³Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁴Medicine, Hospital for Special Surgery, New York, NY, ¹⁵David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ¹⁶University of Birmingham, Birmingham, United Kingdom, ¹⁷Rheumatology, University of Birmingham, Birmingham, United Kingdom, ¹⁸Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁹Brigham and Women's Hospital, Boston, MA
Background/Purpose: Determining the pathologic functions of T cells that infiltrate target tissues remains a central challenge in autoimmune diseases. In rheumatoid arthritis (RA), the formation…
Abstract Number: 3218 • 2016 ACR/ARHP Annual Meeting
Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis
Felice Rivellese¹, Frances Humby¹, Stephen Kelly¹, Amato de Paulis², Gianni Marone² and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy
Background/Purpose: Mast cells (MCs) are immune cells present in the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis, although their exact contribution…
Abstract Number: 1098 • 2015 ACR/ARHP Annual Meeting
Interleukin-1 Reciprocally Regulates Interferon-Gamma Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) and Interleukin-6 in Human Synovial Fibroblasts
Georg Pongratz¹, Rainer Straub² and Torsten Lowin³, ¹Rheumatology - Hiller Research Center Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany, ²Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: B cell activating factor of the tumor necrosis factor family (BAFF) and interleukin-6 (IL-6) are cytokines important for the stimulation and survival of autoreactive…
Abstract Number: 1142 • 2015 ACR/ARHP Annual Meeting
Joint Specific Function of Synovial Fibroblasts – Integrating Positional Transcriptomes and Anatomic Patterns of Arthritis
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Kerstin Klein¹, Emmanuel Karouzakis¹, Christoph Kolling², Andrew Filer³, Christopher Buckley⁴, Beat A. Michel¹, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³University of Birmingham, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Synovial fibroblasts (SF) profoundly influence physiological and pathological processes in the joint such as reaction to inflammatory stimuli and production of extracellular matrix. We…
Abstract Number: 1265 • 2015 ACR/ARHP Annual Meeting
Genetic and Epigenetic Mapping of Very Early RA Synovial Fibroblasts
Emmanuel Karouzakis¹, Andrew Filer², Stephen Eyre³, Karim Raza⁴, Christoph Kolling⁵, Renate E. Gay¹, Beat A. Michel¹, Jane Worthington³, Christopher Buckley⁶, Steffen Gay¹, Michel Neidhart¹ and Caroline Ospelt¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²University of Birmingham, Birmingham, United Kingdom, ³University of Manchester,Institute of Inflammation and Repair, United Kingdom, Manchester, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁵Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁶University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Genome wide association studies (GWAS) studies from rheumatoid arthritis patients have identified SNPs, which are associated with changes in gene expression levels. Recent studies…
Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting
Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)
Rachel Audo^1,2, Bernard Combe^3,4, Michael Hahne⁵ and Jacques Morel⁶, ¹Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, ²IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ³Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁴Montpellier University, Montpellier, France, ⁵IGMM-CNRS UMR5535, Montpellier, France, ⁶Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
Abstract Number: 1627 • 2015 ACR/ARHP Annual Meeting
HIF-1alpha Knockdown Down-Regulates Glycolytic Metabolism and Induces Rheumatoid Synovial Fibroblast Cell Death
Manuel J. Del Rey¹, Alicia Usategui¹, Álvaro Valín¹, María Sánchez-Aragó², José M. Cuezva², Carmen M. García-Herrero¹, María Galindo¹, Juan D. Cañete³, Francisco J. Blanco⁴, Gabriel Criado¹ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Investigación Hospital 12 de Octubre, Universidad Autónoma de Madrid, Madrid, Spain, ³Unitat d’Artritis, Servei de Reumatologia, Hospital Clínic de Barcelona and Institut d’Investigacions Biomèdiques August Pí i Sunyer, Barcelona, Spain, ⁴Laboratorio de Investigación Osteoarticular y del Envejecimiento, Instituto de Investigación Biomédica de A Coruña, INIBIC, A Coruña, Spain
Background/Purpose: Intense synovial fibroblast (SF) hyperplasia contributes to the chronic inflammation and osteoarticular destruction that characterizes rheumatoid arthritis (RA). Hypoxia-inducible factor 1α (HIF-1α) plays a…
Abstract Number: 2133 • 2015 ACR/ARHP Annual Meeting
Receptor Protein Tyrosine Phosphatase Alpha Enhances Rheumatoid Synovial Fibroblast Signaling and Promotes Arthritis in Mice
Stephanie M. Stanford¹, Mattias N. D. Svensson¹, Cristiano Sacchetti¹, Caila A. Pilo¹, Dennis J. Wu¹, William B. Kiosses², Annelie Hellvard³, Brith Bergum³, German R. Aleman Muench¹, Christian Elly¹, Yun-Cai Liu¹, Jeroen den Hertog^4,5, Ari Elson⁶, Jan Sap⁷, Piotr Mydel³, David L. Boyle⁸, Maripat Corr⁸, Gary S. Firestein⁸ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Hubrecht Institute-Koninklijke Nederlands Akademie van Wetenschappen and University Medical Center Utrecht, Utrecht, Netherlands, ⁵Institute of Biology Leiden, Leiden, Netherlands, ⁶Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel, ⁷Epigenetics and Cell Fate, Université Paris Diderot Sorbonne Paris Cité, Paris, France, ⁸Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) promote disease pathogenesis by aggressively invading the joint extracellular matrix. The focal adhesion kinase (FAK) signaling pathway is…
Abstract Number: 2446 • 2015 ACR/ARHP Annual Meeting
Synovial Fluid Proteins Differentiate Patients with Oligoarticular Juvenile Idiopathic Arthritis Who Are Destined to Extend from Those Who Will Remain Persistent in Course
AnneMarie C. Brescia¹, Megan M. Simonds², Kathleen E. Sullivan³ and Carlos D. Rose⁴, ¹Pediatric Rheumatology, Nemours A.I. duPont Hospital for Children, Wilmington, DE, ²Nemours Research, Nemours/AI duPont Hospital for Children, Wilmington, DE, ³Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Pediatrics, Nemours A.I. duPont Hospital for Children, Division of Pediatric Rheumatology, Thomas Jefferson University, Wilmington, DE
Background/Purpose: Children with oligoarticular juvenile idiopathic arthritis (JIA) who have an extended course (recruitment of 5 or more joints after 6 months of disease) have…

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